total androgen blockade (TOH-tul AN-droh-jen blah-KAYD)
Treatment used to block androgen (male hormone) activity in the body. This may be done by removing the testicles (orchiectomy) or giving a gonadotropin-releasing hormone (GnRH) agonist and an antiandrogen drug. Total androgen blockade may stop the growth of cancer cells that need androgens to grow, and is used in the treatment of prostate cancer. Also called combined androgen blockade.