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didanosine
A synthetic nucleoside analogue of deoxyadenosine in which the 3' hydroxyl on the ribose moiety is replaced by a hydrogen atom. In vivo, didanosine is converted to the active triphosphate form, which is incorporated into DNA. The absence of the 3' hydroxyl inhibits DNA elongation because phosphodiester bonds cannot be made with the substituted hydrogen. Check for
active clinical trials
or
closed clinical trials
using this agent. (
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Synonyms:
Didanosine EC
dideoxyinosine
US brand names:
Videx
Videx EC
Abbreviation:
ddI
Chemical structure name:
2',3'-Dideoxyinosine
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