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vindesine
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. Check for
active clinical trials
or
closed clinical trials
using this agent. (
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Synonyms:
Compound 112531
deacetyl vinblastine carboxamide
desacetylvinblastine amide
US brand name:
Eldisine
Abbreviations:
DAVA
DVA
VDS
Code name:
Lilly CT-3231
Chemical structure name:
3-(aminocarbonyl)-O4-deacetyl-3-de-(methoxycarbonyl)vincaleukoblastine
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