Radiation Therapy With or Without Cisplatin in Treating Patients With Recurrent Endometrial Cancer

  • Resize font
  • Print
  • Email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IITreatmentActiveNot specifiedNCI, OtherGOG-0238
NCI-2009-00603, CDR0000550975, U10CA027469, U10CA180868, NCT00492778

Trial Description

Summary

This randomized phase II trial studies radiation therapy and cisplatin to see how well they work compared with radiation therapy alone in treating patients with endometrial cancer that has come back. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving radiation therapy together with cisplatin is more effective than radiation therapy alone in treating patients with endometrial cancer.

Further Study Information

PRIMARY OBJECTIVES:

I. To assess whether pelvic radiation therapy with concurrent cisplatin is more promising with respect to progression-free survival than pelvic radiation therapy alone in the treatment of recurrent uterine carcinoma limited to the pelvis and vagina.

SECONDARY OBJECTIVES:

I. To capture the sites of recurrence subsequent to treatment with pelvic radiation with or without concurrent weekly cisplatin in women with recurrent uterine carcinoma.

II. To estimate overall survival of patients with recurrent uterine carcinoma treated with pelvic radiation therapy with or without concurrent weekly cisplatin.

III. To estimate the prognostic significance of the location (central pelvis versus vagina) and size of the recurrence, in addition to the prognostic significance in the salvage setting of the histological subtype, grade, patient age, race, performance status, and the presence of lymph-vascular space involvement of the original tumor at the time of initial hysterectomy.

IV. To evaluate toxicity derived from the combined cisplatin and radiation compared with radiation alone in this patient population.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients undergo external-beam radiotherapy (EBRT) to the pelvis daily on days 1-5 for 5 weeks. After completion of EBRT, patients undergo intracavitary low-dose rate or high-dose rate brachytherapy* or low-dose rate interstitial brachytherapy*.

ARM II: Patients undergo EBRT as in Arm I and receive cisplatin intravenously (IV) over 1-2 hours on days 1, 8, 15, 22, and 29. Patients then undergo brachytherapy* as in Arm I.

NOTE: *IMRT boost is allowed for patients who are not candidates for brachytherapy. IMRT may also be used for the entire course of therapy for the treatment of the whole pelvis and/or the boost in patients not undergoing brachytherapy. In both arms, treatment continues in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Eligibility Criteria

Inclusion Criteria:

  • All patients must have undergone complete hysterectomy and bilateral salpingo-oophorectomy at the time of original therapy for their uterine carcinoma
  • Patients must have a biopsy with histologically confirmed diagnosis of recurrent endometrial cancer confined to the pelvis and/or vagina and no evidence of extrapelvic disease
  • Patients must have endometrial carcinoma including endometrioid adenocarcinoma, adenocarcinoma with squamous differentiation, mucinous adenocarcinoma, squamous cell carcinoma, mixed carcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, and serous adenocarcinoma histologies
  • Patients must have no evidence of extrapelvic disease; complete workup staging should be performed prior to initiation of therapy to rule-out presence of metastatic disease; this should include: computed tomography (CT) scan of the thorax with IV contrast, as well as a CT of the pelvis and abdomen with IV and oral (PO) contrast performed using multi-detector CT and equal or less than 5 mm slice thickness; if the patient is unable to tolerate contrast, then magnetic resonance imaging (MRI) with IV gadolinium should be performed; a chest x-ray should be done first, and if abnormal, then a CT scan of the chest should be done
  • Primary surgical debulking before protocol therapy is permissible; this would include removal of gross symptomatic disease in the pelvis and/or vagina
  • Exenterative surgery is not permissible; patients with complete resection of gross recurrent disease are eligible
  • Patients may have received prior hormone therapy and/or systemic chemotherapy; such therapy must have been completed at least 6 months prior to study entry and the patient has clear evidence of disease subsequent to such therapy; patients must not have received neoadjuvant chemotherapy for the present recurrent disease
  • Patients must have Gynecologic Oncology Group (GOG) performance status 0, 1, or 2
  • Patients must have an estimated survival greater or equal to 3 months
  • Absolute neutrophil count (ANC) >= 1,500/mm^3 , equivalent to Common Toxicity Criteria (Common Terminology Criteria for Adverse Events [CTCAE] version [v] 3.0) grade 1
  • Platelets >= 100,000/mm^3, equivalent to CTCAE v 3.0 grade 0-1
  • Creatinine =< institutional upper limit normal (ULN), CTCAE v 3.0 grade 0; NOTE: if creatinine > ULN, creatinine clearance must be > 50 mL/min
  • Bilirubin =< 1.5 x ULN (CTCAE v 3.0 grade 1)
  • Serum glutamic oxaloacetic transaminase (SGOT) =< 2.5 x ULN (CTCAE v 3.0 grade 0-1)
  • Alkaline phosphatase =< 2.5 x ULN (CTCAE v 3.0 grade 0-1)
  • Neuropathy (sensory and motor) =< CTCAE v 3.0 grade 1
  • Patients with ureteral obstruction must undergo stent or nephrostomy tube placement prior to study entry
  • Patients who have met the pre-entry requirements
  • Patients must have signed an approved informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization

Exclusion Criteria:

  • Patients with evidence of disease outside of the pelvis, including presence of positive periaortic or inguino-femoral nodes
  • Patients who have received previous vaginal, pelvic, or abdominal irradiation
  • Patients who received chemotherapy directed at the present recurrence
  • Patients with septicemia or severe infection
  • Patients who have circumstances that will not permit completion of this study or the required follow-up
  • Patients with renal abnormalities, such as pelvic kidney, horseshoe kidney, or renal transplantation, that would require modification of radiation fields
  • Patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer, are excluded if there is any evidence of other malignancy being present within the last five years; patients are also excluded if their previous cancer treatment contraindicates this protocol therapy
  • Patients who have undergone complete surgical resection of the recurrent tumor and have no evidence of residual disease evaluable clinically and by CT or MRI imaging, following resection
  • Patients who have a significant history of cardiac disease, i.e., uncontrolled hypertension, unstable angina, congestive heart failure, or uncontrolled arrhythmias within 6 months of registration
  • Patients with history of active collagen vascular disease
  • Patients with GOG performance grade of 3 or 4

Trial Contact Information

Trial Lead Organizations/Sponsors

Gynecologic Oncology Group

  • National Cancer Institute
Jonathan Feddock, Principal Investigator

Trial Sites

U.S.A.

California
Auburn

Auburn Radiation Oncology

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Sutter Auburn Faith Hospital

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Berkeley

Alta Bates Summit Comprehensive Cancer Center

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Burlingame

Peninsula Medical Center

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Cameron Park

Radiation Oncology Centers - Cameron Park

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Davis

Sutter Davis Hospital

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

La Jolla

Rebecca and John Moores UCSD Cancer Center

Higinia R Cardenes Perera

Los Angeles

Kaiser Permanente Medical Center - Los Angeles

Scott E. Lentz
Ph: 626-564-3455

Scott E. Lentz
Ph: 626-564-3455

Modesto

Memorial Medical Center

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Mountain View

Palo Alto Medical Foundation

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Novato

Sutter Health Western Division Cancer Research Group

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Palo Alto

Palo Alto Medical Foundation - Palo Alto

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Roseville

Radiation Oncology Center - Roseville

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Sutter Cancer Center at Roseville Medical Center

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Sacramento

Sutter Cancer Center

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

San Francisco

California Pacific Medical Center - California Campus

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Santa Cruz

Palo Alto Medical Foundation-Santa Cruz

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Santa Rosa

Sutter Pacific Medical Foundation

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Sunnyvale

Palo Atlo Medical Foundation-Sunnyvale

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Vacaville

Solano Radiation Oncology Center

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Vallejo

Sutter Solano Medical Center

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Connecticut
Hartford

Helen and Harry Gray Cancer Center at Hartford Hospital

James S. Hoffman
Ph: 860-224-5660

Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

New Britain

George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus

James S. Hoffman
Ph: 860-224-5660

Delaware
Lewes

Tunnell Cancer Center at Beebe Medical Center

Mark E Borowsky
Ph: 302-733-6227

Newark

Christiana Gynecologic Oncology, LLC

Mark E Borowsky
Ph: 302-733-6227

Delaware Clinical and Laboratory Physicians

Mark E Borowsky
Ph: 302-733-6227

Helen F. Graham Cancer Center at Christiana Hospital

Mark E Borowsky
Ph: 302-733-6227

Mark E Borowsky
Ph: 302-733-6227

Medical Oncology Hematology Consultants, PA at Helen F. Graham Cancer Center

Mark E Borowsky
Ph: 302-733-6227

Regional Hematology/Oncology, PA - Newark

Mark E Borowsky
Ph: 302-733-6227

Rehoboth Beach

Beebe Health Campus

Mark E Borowsky
Ph: 302-733-6227

Seaford

Nanticoke Memorial Hospital

Mark E Borowsky
Ph: 302-733-6227

Wilmington

Christiana Care Health System-Wilmington Hospital

Mark E Borowsky
Ph: 302-733-6227

District of Columbia
Washington

Sibley Memorial Hospital

Mildred Rodriguez Chernofsky
Ph: 202-243-2373

Florida
Sarasota

Sarasota Memorial Hospital

James V. Fiorica
Ph: 941-917-2225

Georgia
Atlanta

Northside Hospital Cancer Center

Guilherme C. Cantuaria
Ph: 404-303-3355
Email: clinicaltrials@northside.com

Gainesville

Northeast Georgia Medical Center

Andrew E Green
Ph: 770-219-8800
Email: cancerpatient.navigator@nghs.com

Savannah

Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

James J Burke
Ph: 912-350-8568

Idaho
Boise

Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

Philip J. Stella
Ph: 734-712-4673

Illinois
Chicago

Robert H. Lurie Comprehensive Cancer Center at Northwestern University

Emily Berry
Ph: 312-695-1301
Email: cancer@northwestern.edu

Evanston

CCOP - Evanston

Jean A. Hurteau
Ph: 847-570-2109

Galesburg

Medical and Surgical Specialists, LLC

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Hinsdale

Gynecologic Oncology

Sudarshan K. Sharma
Ph: 630-856-6757

Moline

Garneau, Stewart C MD (UIA Investigator)

David M Spector
Ph: 309-779-4200

Spector, David MD (UIA Investigator)

David M Spector
Ph: 309-779-4200

Trinity Cancer Center at Trinity Medical Center - 7th Street Campus

David M Spector
Ph: 309-779-4200

Oak Lawn

Advocate Christ Medical Center

Renee H. Jacobs
Ph: 630-856-7526

Warrenville

Central Dupage Cancer Center

LaToya J Perry
Ph: 630-208-4563
Email: kevin.tomczyk@delnor.com

Indiana
Indianapolis

Indiana University Melvin and Bren Simon Cancer Center

Jeanne M Schilder
Ph: 317-274-2552

Iowa
Bettendorf

Constantinou, Costas L MD (UIA Investigator)

David M Spector
Ph: 309-779-4200

Iowa City

Holden Comprehensive Cancer Center at University of Iowa

David P Bender
Ph: 800-237-1225

Sioux City

Siouxland Hematology-Oncology Associates, LLP

Donald Bruce Wender
Ph: 712-252-0088

Kansas
Chanute

Cancer Center of Kansas, PA - Chanute

Shaker R. Dakhil
Ph: 316-262-4467

Dodge City

Cancer Center of Kansas, PA - Dodge City

Shaker R. Dakhil
Ph: 316-262-4467

El Dorado

Cancer Center of Kansas, PA - El Dorado

Shaker R. Dakhil
Ph: 316-262-4467

Fort Scott

Cancer Center of Kansas - Fort Scott

Shaker R. Dakhil
Ph: 316-262-4467

Independence

Cancer Center of Kansas-Independence

Shaker R. Dakhil
Ph: 316-262-4467

Kingman

Cancer Center of Kansas, PA - Kingman

Shaker R. Dakhil
Ph: 316-262-4467

Lawrence

Lawrence Memorial Hospital

Shaker R. Dakhil
Ph: 316-262-4467

Liberal

Cancer Center of Kansas, PA - Liberal

Shaker R. Dakhil
Ph: 316-262-4467

Newton

Cancer Center of Kansas, PA - Newton

Shaker R. Dakhil
Ph: 316-262-4467

Overland Park

Menorah Medical Center

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Saint Luke's Hospital - South

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Parsons

Cancer Center of Kansas, PA - Parsons

Shaker R. Dakhil
Ph: 316-262-4467

Pratt

Cancer Center of Kansas, PA - Pratt

Shaker R. Dakhil
Ph: 316-262-4467

Salina

Cancer Center of Kansas, PA - Salina

Shaker R. Dakhil
Ph: 316-262-4467

Wellington

Cancer Center of Kansas, PA - Wellington

Shaker R. Dakhil
Ph: 316-262-4467

Wichita

Associates in Women's Health, PA - North Hillside

Shaker R. Dakhil
Ph: 316-262-4467

Cancer Center of Kansas, PA - Medical Arts Tower

Shaker R. Dakhil
Ph: 316-262-4467

Cancer Center of Kansas, PA - Wichita

Shaker R. Dakhil
Ph: 316-262-4467

Via Christi Cancer Center at Via Christi Regional Medical Center

Shaker R. Dakhil
Ph: 316-262-4467

Wesley Medical Center

Shaker R. Dakhil
Ph: 316-262-4467

Winfield

Cancer Center of Kansas, PA - Winfield

Shaker R. Dakhil
Ph: 316-262-4467

Kentucky
Edgewood

St. Elizabeth Medical Center

Jack Basil
Ph: 513-862-2230

Louisiana
Baton Rouge

Woman's Hospital

Giles Fort
Ph: 225-231-5296
Email: Ericka.Seidemann@womans.org

Maine
Portland

Maine Medical Center - Bramhall Campus

Christopher J Darus
Ph: 207-885-7565

Scarborough

Maine Medical Center- Scarborough Campus

Christopher J Darus
Ph: 207-885-7565

Maryland
Baltimore

Alvin and Lois Lapidus Cancer Institute at Sinai Hospital

Fouad M Abbas
Ph: 410-601-6120
Email: pridgely@lifebridgehealth.org

Greater Baltimore Medical Center Cancer Center

Paul Celano
Ph: 443-849-3706

Massachusetts
Burlington

Lahey Clinic Medical Center - Burlington

Corrine L Zarwan
Ph: 781-744-8027

Worcester

Levine Cancer Center at UMass Medical Center - Memorial Campus

Susan L. Zweizig
Ph: 508-856-3216
Email: cancer.research@umassmed.edu

Michigan
Ann Arbor

Saint Joseph Mercy Cancer Center

Philip J. Stella
Ph: 734-712-4673

Dearborn

Oakwood Cancer Center at Oakwood Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Detroit

Van Elslander Cancer Center at St. John Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Wayne State University

Robert T. Morris
Ph: 313-576-9363

Farmington Hills

Weisberg Cancer Treatment Center

Robert T. Morris
Ph: 313-576-9363

Flint

Genesys Hurley Cancer Institute

Philip J. Stella
Ph: 734-712-4673

Hurley Medical Center

Philip J. Stella
Ph: 734-712-4673

Jackson

Gayle M. Jacob Cancer Center at Allegiance Health

Philip J. Stella
Ph: 734-712-4673

Kalamazoo

Borgess Medical Center

Raymond Sterling Lord
Ph: 269-373-7458

Bronson Methodist Hospital

Raymond Sterling Lord
Ph: 269-373-7458

West Michigan Cancer Center

Raymond Sterling Lord
Ph: 269-373-7458

Lansing

Sparrow Regional Cancer Center

Philip J. Stella
Ph: 734-712-4673

Livonia

St. Mary Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Pontiac

St. Joseph Mercy Oakland

Philip J. Stella
Ph: 734-712-4673

Port Huron

Mercy Regional Cancer Center at Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Saginaw

Seton Cancer Institute at Saint Mary's - Saginaw

Philip J. Stella
Ph: 734-712-4673

Warren

St. John Macomb Hospital

Philip J. Stella
Ph: 734-712-4673

Mississippi
Jackson

University of Mississippi Cancer Clinic

James Tate Thigpen
Ph: 601-815-6700

Pascagoula

Regional Cancer Center at Singing River Hospital

James E. Clarkson
Ph: 228-809-5292

Missouri
Columbia

Ellis Fischel Cancer Center at University of Missouri - Columbia

Akm Mosharraf Hossain
Ph: 573-882-7440

Independence

Independence Regional Health Center

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Kansas City

Heartland Hematology Oncology Associates, Incorporated

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Research Medical Center

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Saint Luke's Hospital

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Lee's Summit

Saint Luke's East - Lee's Summit

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Liberty

Parvin Radiation Oncology

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Saint Joseph

Heartland Regional Medical Center

Rakesh Gaur
Ph: 913-948-5588
Email: aroland@kccop.org

Saint Louis

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

David Gardner Mutch
Ph: 800-600-3606
Email: info@ccadmin.wustl.edu

Springfield

Hulston Cancer Center at Cox Medical Center South

Jay W Carlson
Ph: 800-821-7532

St. John's Regional Health Center

Jay W Carlson
Ph: 800-821-7532

Montana
Billings

Billings Clinic Cancer Center - 801 N 29th Street

Benjamin Thomas Marchello
Ph: 800-648-6274

CCOP - Montana Cancer Consortium

Benjamin Thomas Marchello
Ph: 800-648-6274

St. Vincent Healthcare Cancer Care Services

Benjamin Thomas Marchello
Ph: 800-648-6274

Bozeman

Bozeman Deaconess Cancer Center

Benjamin Thomas Marchello
Ph: 800-648-6274

Butte

St. James Healthcare Cancer Care

Benjamin Thomas Marchello
Ph: 800-648-6274

Great Falls

Benefis Sletten Cancer Institute

Benjamin Thomas Marchello
Ph: 800-648-6274

Helena

St. Peter's Hospital

Benjamin Thomas Marchello
Ph: 800-648-6274

Kalispell

Kalispell Regional Medical Center

Benjamin Thomas Marchello
Ph: 800-648-6274

Missoula

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

Benjamin Thomas Marchello
Ph: 800-648-6274

Nebraska
Omaha

Methodist Estabrook Cancer Center

Peter C. Morris
Ph: 402-354-7939
Email: kathryn.bartz@nmhs.org

Nevada
Henderson

21st Century Oncology - Henderson

John Allan Ellerton
Ph: 702-384-0013

Cancer and Blood Specialists-Henderson

John Allan Ellerton
Ph: 702-384-0013

Comprehensive Cancer Centers of Nevada - Henderson

John Allan Ellerton
Ph: 702-384-0013

Comprehensive Cancer Centers of Nevada-Southeast Henderson

John Allan Ellerton
Ph: 702-384-0013

Las Vegas Cancer Center - Henderson

John Allan Ellerton
Ph: 702-384-0013

Las Vegas

21st Century Oncology - Fort Apache

John Allan Ellerton
Ph: 702-384-0013

21st Century Oncology - Vegas Sunrise

John Allan Ellerton
Ph: 702-384-0013

21st Century Oncology - Vegas Tenaya

John Allan Ellerton
Ph: 702-384-0013

Cancer and Blood Specialists-Fort Apache

John Allan Ellerton
Ph: 702-384-0013

Cancer and Blood Specialists-Shadow

John Allan Ellerton
Ph: 702-384-0013

Cancer and Blood Specialists-Tenaya

John Allan Ellerton
Ph: 702-384-0013

Cancer Institute of Nevada at Summerlin Hospital Medical Center

John Allan Ellerton
Ph: 702-384-0013

Cancer Therapy and Integrative Medicine

John Allan Ellerton
Ph: 702-384-0013

CCOP - Nevada Cancer Research Foundation

John Allan Ellerton
Ph: 702-384-0013

Comprehensive Cancer Centers of Nevada - Central Valley

John Allan Ellerton
Ph: 702-384-0013

Comprehensive Cancer Centers of Nevada - Northwest

John Allan Ellerton
Ph: 702-384-0013

Comprehensive Cancer Centers of Nevada - Southwest

John Allan Ellerton
Ph: 702-384-0013

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

John Allan Ellerton
Ph: 702-384-0013

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

John Allan Ellerton
Ph: 702-384-0013

HealthCare Partners Medical Group Oncology/Hematology-San Martin

John Allan Ellerton
Ph: 702-384-0013

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

John Allan Ellerton
Ph: 702-384-0013

Las Vegas Cancer Center-Medical Center

John Allan Ellerton
Ph: 702-384-0013

Radiation Oncology Centers of Las Vegas - Downtown Location

John Allan Ellerton
Ph: 702-384-0013

Radiation Oncology Centers of Las Vegas - Eastern Location

John Allan Ellerton
Ph: 702-384-0013

University Medical Center of Southern Nevada

John Allan Ellerton
Ph: 702-384-0013

Women's Cancer Center - La Canada

Nick M. Spirtos
Ph: 702-851-4672

New Hampshire
Lebanon

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

Leslie R. DeMars
Ph: 800-639-6918
Email: cancer.research.nurse@dartmouth.edu

Manchester

Elliot Regional Cancer Center at Elliot Hospital

Brian R Knab
Ph: 603-663-1800

New Jersey
Camden

Cancer Institute of New Jersey at Cooper University Hospital - Camden

David P. Warshal
Ph: 856-325-6757

Mount Holly

Virtua Fox Chase Health Cancer Program at Virtua Memorial Hospital Burlington County

Randolph B Deger
Ph: 888-847-8823

Newark

UMDNJ University Hospital

Bernadette M. Cracchiolo
Ph: 732-235-8675

Phillipsburg

Women’s Institute for Gynecologic Cancer and Special Pelvic Surgery

David Foster Silver
Ph: 718-765-2500

Toms River

J. Phillip Citta Regional Cancer Center at Community Medical Center

David J D'Ambrosio
Ph: 732-818-3882

Voorhees

Cancer Institute of New Jersey at Cooper - Voorhees

David P. Warshal
Ph: 856-325-6757

Fox Chase Virtua Health Cancer Program at Virtua West Jersey

Randolph B Deger
Ph: 888-847-8823

New Mexico
Albuquerque

University of New Mexico Cancer Center

Higinia R Cardenes Perera

New York
Brooklyn

SUNY Downstate Medical Center

Ovadia Abulafia
Ph: 718-270-8216
Email: sima.terebelo@downstate.edu

Manhasset

Don Monti Comprehensive Cancer Center at North Shore University Hospital

Veena S John
Ph: 516-562-3467

New Hyde Park

Long Island Jewish Medical Center

Veena S John
Ph: 516-562-3467

Monter Cancer Center of the North Shore-LIJ Health System

Veena S John
Ph: 516-562-3467

Stony Brook

Stony Brook University Cancer Center

Michael L. Pearl
Ph: 800-862-2215

Syracuse

SUNY Upstate Medical University Hospital

Mary J Cunningham
Ph: 315-464-5476

North Carolina
Charlotte

Presbyterian Cancer Center at Presbyterian Hospital

John M McDonald
Ph: 704-384-5369

Clinton

Southeastern Medical Oncology Center-Clinton

James N. Atkins
Ph: 919-580-0000

Goldsboro

Southeastern Medical Oncology Center - Goldsboro

James N. Atkins
Ph: 919-580-0000

Wayne Memorial Hospital, Incorporated

James N. Atkins
Ph: 919-580-0000

Jacksonville

Southeastern Medical Oncology Center-Jacksonville

James N. Atkins
Ph: 919-580-0000

Wilson

Southeastern Medical Oncology Center - Wilson

James N. Atkins
Ph: 919-580-0000

Winston-Salem

Wake Forest University Comprehensive Cancer Center

Samuel S. Lentz
Ph: 336-713-6771

Ohio
Beachwood

UHHS Chagrin Highlands Medical Center

Steven E. Waggoner
Ph: 800-641-2422

Belpre

Strecker Cancer Center-Belpre

J. Philip Kuebler
Ph: 614-566-3275

Canton

Aultman Cancer Center at Aultman Hospital

Michael P. Hopkins
Ph: 330-363-6891

Chillicothe

Adena Regional Medical Center

J. Philip Kuebler
Ph: 614-566-3275

Cincinnati

Bethesda North Hospital

James C Pavelka
Ph: 513-862-2230

Good Samaritan Hospital Cancer Treatment Center

James C Pavelka
Ph: 513-862-2230

Cleveland

Case Comprehensive Cancer Center

Steven E. Waggoner
Ph: 800-641-2422

Cleveland Clinic Cancer Center at Fairview Hospital

Peter Graham Rose
Ph: 866-223-8100

Cleveland Clinic Taussig Cancer Center

Peter Graham Rose
Ph: 866-223-8100

Columbus

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

Higinia R Cardenes Perera

Columbus Oncology Associates, Incorporated

J. Philip Kuebler
Ph: 614-566-3275

Doctors Hospital at Ohio Health

J. Philip Kuebler
Ph: 614-566-3275

Grant Medical Center Cancer Care

J. Philip Kuebler
Ph: 614-566-3275

Mount Carmel Health - West Hospital

J. Philip Kuebler
Ph: 614-566-3275

Riverside Methodist Hospital Cancer Care

J. Philip Kuebler
Ph: 614-566-3275

Zangmeister Center

J. Philip Kuebler
Ph: 614-566-3275

Delaware

Delaware Health Center

J. Philip Kuebler
Ph: 614-566-3275

Delaware Radiation Oncology

J. Philip Kuebler
Ph: 614-566-3275

Grady Memorial Hospital

J. Philip Kuebler
Ph: 614-566-3275

Lancaster

Fairfield Medical Center

J. Philip Kuebler
Ph: 614-566-3275

Marietta

Strecker Cancer Center at Marietta Memorial Hospital

J. Philip Kuebler
Ph: 614-566-3275

Mayfield Heights

Hillcrest Cancer Center at Hillcrest Hospital

Peter Graham Rose
Ph: 866-223-8100

University Hospitals Ireland Cancer Center at Landerbrook Health Center

Steven E. Waggoner
Ph: 800-641-2422

Mentor

Lake/University Ireland Cancer Center

Steven E. Waggoner
Ph: 800-641-2422

Mount Vernon

Knox Community Hospital

J. Philip Kuebler
Ph: 614-566-3275

Newark

Licking Memorial Cancer Care Program at Licking Memorial Hospital

J. Philip Kuebler
Ph: 614-566-3275

Newark Radiation Oncology

J. Philip Kuebler
Ph: 614-566-3275

Portsmouth

Southern Ohio Medical Center Cancer Center

J. Philip Kuebler
Ph: 614-566-3275

Springfield

Community Hospital of Springfield and Clark County

J. Philip Kuebler
Ph: 614-566-3275

Sylvania

Flower Hospital Cancer Center

Rex B Mowat
Ph: 800-444-3561

Toledo

CCOP - Toledo Community Hospital

Rex B Mowat
Ph: 800-444-3561

University of Toledo Medical Center

Rex B Mowat
Ph: 800-444-3561

Wadsworth

University Hospitals Sharon Health Center

Steven E. Waggoner
Ph: 800-641-2422

Westerville

Mount Carmel St. Ann's Cancer Center

J. Philip Kuebler
Ph: 614-566-3275

Westlake

UHHS Westlake Medical Center

Steven E. Waggoner
Ph: 800-641-2422

Zanesville

Genesis - Good Samaritan Hospital

J. Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

Oklahoma
Oklahoma City

Stephenson Cancer Center at the University of Oklahoma

Robert S. Mannel
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Tulsa

Cancer Care Associates-Yale

Robert S. Mannel
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Pennsylvania
Abington

Rosenfeld Cancer Center at Abington Memorial Hospital

Parviz Hanjani
Ph: 215-481-2402

Danville

Geisinger Cancer Institute at Geisinger Health

Radhika P Gogoi
Ph: 570-271-5251

Gettysburg

Adams Cancer Center

Mark A Miller
Ph: 877-441-7957

Hanover

Cherry Tree Cancer Center

Mark A Miller
Ph: 877-441-7957

West Reading

McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

Bernice L Robinson-Bennett
Ph: 610-988-9323

Wilkes-Barre

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

Radhika P Gogoi
Ph: 570-271-5251

Wynnewood

Lankenau Cancer Center at Lankenau Hospital

Paul B. Gilman
Ph: 484-476-2649
Email: wellenbachj@mlhs.org

York

WellSpan Health

Mark A Miller
Ph: 877-441-7957

York Cancer Center at Apple Hill Medical Center

Mark A Miller
Ph: 877-441-7957

South Carolina
Easley

Cancer Centers of the Carolinas - Easley

Jeffrey W Elder
Ph: 864-679-3966

Greenville

Cancer Centers of the Carolinas - Andrews

Jeffrey W Elder
Ph: 864-679-3966

Cancer Centers of the Carolinas - Faris Road

Jeffrey W Elder
Ph: 864-679-3966

Cancer Centers of the Carolinas - Grove Commons

Jeffrey W Elder
Ph: 864-679-3966

CCOP - Greenville

Jeffrey W Elder
Ph: 864-679-3966

Greenville Memorial Hospital

Jeffrey W Elder
Ph: 864-679-3966

Greer

Cancer Centers of the Carolinas - Greer Radiation Oncology

Jeffrey W Elder
Ph: 864-679-3966

Seneca

Cancer Centers of the Carolinas - Seneca

Jeffrey W Elder
Ph: 864-679-3966

Spartanburg

Cancer Centers of the Carolinas - Spartanburg

Jeffrey W Elder
Ph: 864-679-3966

South Dakota
Sioux Falls

Avera Cancer Institute

Luis A Rojas-Espaillat
Ph: 800-657-4377
Email: Jan.Healy@avera.org

Tennessee
Knoxville

U.T. Medical Center Cancer Institute

Larry C Kilgore
Ph: 865-544-9773

Texas
Dallas

Parkland Memorial Hospital

David Scott Miller
Ph: 214-648-7097

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

David Scott Miller
Ph: 214-648-7097

Houston

Memorial Hermann - Texas Medical Center

Anthony Lucci
Ph: 866-574-5124
Email: Sylvester@emergingmed.com

Utah
Salt Lake City

Huntsman Cancer Institute at University of Utah

Andrew P Soisson
Ph: 801-581-4477
Email: clinical.trials@hci.utah.edu

Vermont
Burlington

University of Vermont Medical Center

Cheung Wong
Ph: 802-656-8990

Wisconsin
Green Bay

Green Bay Oncology, Limited at St. Mary's Hospital

Jonathan E Tammela
Ph: 920-433-8889

Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

Jonathan E Tammela
Ph: 920-433-8889

St. Mary's Hospital Medical Center - Green Bay

Jonathan E Tammela
Ph: 920-433-8889

St. Vincent Hospital Regional Cancer Center

Jonathan E Tammela
Ph: 920-433-8889

La Crosse

Gundersen Lutheran Center for Cancer and Blood

Kurt Oettel
Ph: 608-775-2385
Email: cancerctr@gundluth.org

Madison

University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

David M Kushner
Ph: 877-405-6866

Milwaukee

Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

Ali Mahdavi
Ph: 414-649-5717

Wyoming
Sheridan

Welch Cancer Center at Sheridan Memorial Hospital

Benjamin Thomas Marchello
Ph: 800-648-6274

Link to the current ClinicalTrials.gov record.
NLM Identifier NCT00492778
ClinicalTrials.gov processed this data on April 09, 2015

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.