Pazopanib Hydrochloride in Treating Patients with Metastatic Kidney Cancer Who Have No Evidence of Disease after Surgery

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Basic Trial Information

PhaseTypeAgeTrial IDs
Phase IIIBiomarker/Laboratory analysis, Tissue collection/Repository, Treatment18 and overE2810
NCI-2012-00723, CDR0000730383, ECOG-E2810, NCT01575548

Trial Description

Summary

This randomized phase III trial studies how well pazopanib hydrochloride works compared to placebo in treating patients with kidney cancer that has spread to other parts of the body who have no evidence of disease after surgery. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

Further Study Information

PRIMARY OBJECTIVES:

I. To evaluate disease-free survival with pazopanib (pazopanib hydrochloride) as compared to placebo, defined as the time from randomization to the development of recurrent disease, second primary cancer (other than localized breast, localized prostate, or non-melanoma skin cancer) or death from any cause for patients with metastatic renal cell carcinoma (RCC) with no evidence of disease following metastasectomy.

SECONDARY OBJECTIVES:

I. To describe the overall survival of patients with advanced RCC randomly assigned to receive placebo or pazopanib for one year following metastasectomy to no evidence of disease (NED).

II. To describe treatment and (at recurrence) disease-related adverse events in the two treatment arms.

III. To analyze quality-adjusted time without symptoms of disease or treatment (Q-TWiST) for subjects in the two treatment arms.

IV. To characterize changes in patient-reported fatigue and (at recurrence) kidney cancer-related symptoms during and following treatment with pazopanib compared to placebo.

V. To explore the association between plasma trough levels of pazopanib and disease-free and overall survival.

VI. To prospectively bank preserved tissue from primary tumors and associated metastatic sites in patients with RCC.

OUTLINE: Patients are randomized to 1of 2 treatment arms.

ARM I: Patients receive pazopanib hydrochloride orally (PO) once daily (QD) on days 1-28. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive placebo PO QD on days 1-28. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for the first two years, every 6 months for the next 3 years, and then annually up to 10 years.

Eligibility Criteria

Inclusion Criteria:

Patient must have no evidence of disease on post-operative imaging:

A computed tomography (CT) of the chest must be obtained within 4 weeks prior to randomization with or without contrast

A CT of the abdomen/pelvis must be obtained within 4 weeks prior to randomization with intravenous (IV) contrast (oral contrast may be added at the radiologist’s discretion); an magnetic resonance imaging (MRI) of the abdomen/pelvis with gadolinium may be substituted for the CT if the CT with IV contrast is contra-indicated

An MRI of the brain with and without gadolinium must be done within 8 weeks prior to randomization; a CT of the brain with and without IV contrast is permitted if MRI is contra-indicated (i.e., pacemaker)

Patient must have undergone surgical resection to remove one or more sites of metastatic disease, with successful removal of all known sites 2-12 weeks prior to randomization; any number of prior metastasectomies may have been performed in the past, so long as the most recent procedure was within the 12 weeks of registration; the most recent procedure may be nephrectomy for a renal primary tumor

Patient must have pathologically confirmed renal cell carcinoma with a clear cell component; pure papillary and chromophobe histologies are excluded; there must be pathologic confirmation of metastatic disease in the resected metastasectomy specimen

Patients must not have any history of other cancer within 3 years from time of randomization with the exception of basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, ductal or lobular carcinoma in situ of the breast, or resected non-invasive (Ta) urothelial carcinoma

Patient must not be taking drugs known to prolong the QTc interval; such drugs should be discontinued at least 5 half-lives prior to randomization

Patient must not have history of hemoptysis in excess of 2.5 mL (1/2 teaspoon) within 8 weeks prior to randomization

Patient cannot be taking strong cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) inhibitors such as:

Antibiotics: clarithromycin, telithromycin, troleandomycin

Human immunodeficiency virus (HIV) antiviral protease inhibitors: ritonavir, indinavir, saquinavir, nelfinavir, amprenavir, lopinavir

Antifungals: itraconazole, ketoconazole, voriconazole, fluconazole

Antidepressants: nefazodone

Patient must have no history of venous thrombosis within 12 weeks of randomization

Patient must have no history of myocardial infarction, hospital admission for unstable angina, cardiac angioplasty or stenting within 6 months of randomization

Patient must have no history of cerebrovascular accident (CVA) within 6 months of randomization

Patient must have no history of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 4 weeks prior to randomization

Patient must not have serious or non-healing wound, ulcer, or bone fracture at the time of randomization

Patient must have a systolic blood pressure =< 140 mmHg and diastolic blood pressure must be =< 90 mmHg, measured within 4 weeks prior to randomization; initiation or adjustment of anti-hypertensives prior to starting study treatment is allowed

Patient must have no uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

Patient must have no history of allergic reactions attributed to compounds of similar chemical or biologic composition to pazopanib

Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study; should a woman become pregnant while participating in this study, she should inform her treating physician immediately; if a man impregnates a woman while participating in this study, he should inform his treating physician immediately

Women must not be pregnant or breast-feeding

All females of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)

Subjects must have a urine protein/creatinine (UPC) ratio < 1; if UPC >= 1, then a 24-hour urine total protein must be obtained; subjects must have a 24-hour urine protein value < 1 g to be eligible; use of urine dipstick for renal function assessment is not acceptable

Calculated creatinine clearance (CrCl) > 30 mL/min

Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) < 2.5 x upper limit of normal (ULN)

Platelets > 100,000/mcL

Absolute granulocyte count > 1,500/mcL

Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 at the time of randomization

Patient must have no prior history or current clinically apparent central nervous system metastases

Patient must have no New York Heart Association (NYHA) class II or greater congestive heart failure

Patient must have no active inflammatory bowel disease

Patient must have no active peptic ulcer disease

Patient must not have received any prior or concurrent systemic therapy for RCC; adjuvant placebo administration is permitted

Positive surgical margins are permitted if the surgeon confirms complete resection of gross metastatic disease, and post-operative scans are negative

Patients with synchronous disease at initial diagnosis must have metastatic (M1) disease (American Joint Committee on Cancer [AJCC] 7th edition T1-4N0-1M1)

Patient must be able to swallow pills and have no significant impairment in gastrointestinal absorption including history of gastric bypass surgery

Patients presenting with tumors within the kidneys (multiple synchronous or single/multiple metachronous) are not eligible if there are no extrarenal sites of disease (i.e. potential multifocal primary disease)

Patients presenting with metachronous disease may have distant metastases, regional lymph node or renal bed recurrence; recurrences at a partial nephrectomy resection site are not eligible if it is the only site of disease

Patient must have undergone nephrectomy or partial nephrectomy to remove primary renal cell carcinoma (at any time in the past)

Patient must have a corrected QT (QTc) interval on electrocardiogram (ECG) =< 0.48 seconds by Bazett’s calculation (=< Common Terminology Criteria for Adverse Events [CTCAE] version [v.]4 grade 2) prior to randomization

Total bilirubin < 1.5 x institutional upper limit of normal (ULN)

Trial Contact Information

Trial Lead Organizations / Sponsors / Collaborators

National Cancer Institute

  • National Cancer Institute
Leonard Joseph Appleman, Principal Investigator

Trial Sites

U.S.A.

Alaska
Fairbanks

Fairbanks Memorial Hospital

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

California
Duarte

City of Hope Comprehensive Cancer Center

Sumanta Kumar Pal
Ph: 800-826-4673
Email: becomingapatient@coh.org

Sumanta Kumar Pal
Principal Investigator

La Jolla

UC San Diego Moores Cancer Center

Frederick Edward Millard
Ph: 858-822-5354
Email: cancercto@ucsd.edu

Frederick Edward Millard
Principal Investigator

Los Angeles

Los Angeles County-USC Medical Center

David Ian Quinn
Ph: 323-865-0451

David Ian Quinn
Principal Investigator

USC / Norris Comprehensive Cancer Center

David Ian Quinn
Ph: 323-865-0451

David Ian Quinn
Principal Investigator

Pismo Beach

Palchak David MD

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Connecticut
Hartford

Saint Francis Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Delaware
Lewes

Beebe Medical Center

Gregory Andrew Masters
Ph: 302-733-6227

Gregory Andrew Masters
Principal Investigator

Newark

Christiana Care Health System-Christiana Hospital

Gregory Andrew Masters
Ph: 302-733-6227

Gregory Andrew Masters
Principal Investigator

Christiana Gynecologic Oncology LLC

Gregory Andrew Masters
Ph: 302-733-6227

Gregory Andrew Masters
Principal Investigator

Delaware Clinical and Laboratory Physicians PA

Gregory Andrew Masters
Ph: 302-733-6227

Gregory Andrew Masters
Principal Investigator

Helen F Graham Cancer Center

Gregory Andrew Masters
Ph: 302-733-6227

Gregory Andrew Masters
Principal Investigator

Medical Oncology Hematology Consultants PA

Gregory Andrew Masters
Ph: 302-733-6227

Gregory Andrew Masters
Principal Investigator

Regional Hematology and Oncology PA

Gregory Andrew Masters
Ph: 302-733-6227

Gregory Andrew Masters
Principal Investigator

Rehoboth Beach

Beebe Health Campus

Gregory Andrew Masters
Ph: 302-733-6227

Gregory Andrew Masters
Principal Investigator

Seaford

Nanticoke Memorial Hospital

Gregory Andrew Masters
Ph: 302-733-6227

Gregory Andrew Masters
Principal Investigator

Wilmington

Christiana Care Health System-Wilmington Hospital

Gregory Andrew Masters
Ph: 302-733-6227

Gregory Andrew Masters
Principal Investigator

District of Columbia
Washington

MedStar Georgetown University Hospital

Nancy Ann Dawson
Ph: 202-444-0381

Nancy Ann Dawson
Principal Investigator

Georgia
Atlanta

Emory University/Winship Cancer Institute

Wayne Bernard Harris
Ph: 404-778-1868

Wayne Bernard Harris
Principal Investigator

Saint Joseph's Hospital of Atlanta

Wayne Bernard Harris
Ph: 404-778-1868

Wayne Bernard Harris
Principal Investigator

Columbus

John B Amos Cancer Center

Andrew W. Pippas
Ph: 706-660-6404

Andrew W. Pippas
Principal Investigator

Gainesville

Northeast Georgia Medical Center

Richard John LoCicero
Ph: 770-219-8800
Email: cancerpatient.navigator@nghs.com

Richard John LoCicero
Principal Investigator

Savannah

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Grant Carlton Lewis
Ph: 912-350-8568

Grant Carlton Lewis
Principal Investigator

Idaho
Boise

Saint Alphonsus Cancer Care Center-Boise

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Coeur D'Alene

Kootenai Medical Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Post Falls

Kootenai Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Sandpoint

Kootenai Cancer

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Illinois
Aurora

Rush - Copley Medical Center

Vamsi Krishna Vasireddy
Ph: 800-446-5532

Vamsi Krishna Vasireddy
Principal Investigator

Bloomington

Illinois CancerCare-Bloomington

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Saint Joseph Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Canton

Illinois CancerCare-Canton

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Carbondale

Memorial Hospital of Carbondale

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Carthage

Illinois CancerCare-Carthage

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Centralia

Centralia Oncology Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Chicago

Northwestern University

Timothy M. Kuzel
Ph: 312-695-1301
Email: cancer@northwestern.edu

Timothy M. Kuzel
Principal Investigator

Danville

Carle on Vermilion

Vamsi Krishna Vasireddy
Ph: 800-446-5532

Vamsi Krishna Vasireddy
Principal Investigator

Decatur

Cancer Care Center of Decatur

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Decatur Memorial Hospital

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Effingham

Carle Physician Group-Effingham

Vamsi Krishna Vasireddy
Ph: 800-446-5532

Vamsi Krishna Vasireddy
Principal Investigator

Crossroads Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Eureka

Illinois CancerCare-Eureka

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Galesburg

Illinois CancerCare Galesburg

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Illinois CancerCare-Galesburg Cottage Plaza Office

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Western Illinois Cancer Treatment Center

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Highland Park

Hematology Oncology Associates of Illinois-Highland Park

Timothy M. Kuzel
Ph: 312-695-1301
Email: cancer@northwestern.edu

Timothy M. Kuzel
Principal Investigator

Kankakee

Presence Saint Mary's Hospital

Timothy M. Kuzel
Ph: 312-695-1301
Email: cancer@northwestern.edu

Timothy M. Kuzel
Principal Investigator

Kewanee

Illinois CancerCare-Kewanee Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Libertyville

NorthShore Hematology Oncology-Libertyville

Timothy M. Kuzel
Ph: 312-695-1301
Email: cancer@northwestern.edu

Timothy M. Kuzel
Principal Investigator

Macomb

Illinois CancerCare-Macomb

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Mattoon

Carle Physician Group-Mattoon/Charleston

Vamsi Krishna Vasireddy
Ph: 800-446-5532

Vamsi Krishna Vasireddy
Principal Investigator

Maywood

Loyola University Medical Center

Joseph I. Clark
Ph: 708-226-4357

Joseph I. Clark
Principal Investigator

Niles

Illinois Cancer Specialists-Niles

Timothy M. Kuzel
Ph: 312-695-1301
Email: cancer@northwestern.edu

Timothy M. Kuzel
Principal Investigator

Ottawa

Illinois CancerCare-Ottawa Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Radiation Oncology of Northern Illinois

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Pekin

Illinois CancerCare-Pekin

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Pekin Cancer Treatment Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Peoria

Illinois CancerCare-Peoria

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Methodist Medical Center of Illinois

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

OSF Saint Francis Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Peru

Illinois CancerCare-Peru

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Valley Radiation Oncology

Nguyet Anh Le-Lindqwister
Ph: 800-793-2262

Nguyet Anh Le-Lindqwister
Principal Investigator

Princeton

Illinois CancerCare-Princeton

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Skokie

Hematology Oncology Associates of Illinois - Skokie

Timothy M. Kuzel
Ph: 312-695-1301
Email: cancer@northwestern.edu

Timothy M. Kuzel
Principal Investigator

Springfield

Central Illinois Hematology Oncology Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Memorial Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Southern Illinois University School of Medicine

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Springfield Clinic

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Urbana

Carle Cancer Center

Vamsi Krishna Vasireddy
Ph: 800-446-5532

Vamsi Krishna Vasireddy
Principal Investigator

The Carle Foundation Hospital

Vamsi Krishna Vasireddy
Ph: 800-446-5532

Vamsi Krishna Vasireddy
Principal Investigator

Warrenville

Cadence Cancer Center in Warrenville

Robert Michael Eisner
Ph: 630-352-5300

Robert Michael Eisner
Principal Investigator

Yorkville

Rush-Copley Healthcare Center

Vamsi Krishna Vasireddy
Ph: 800-446-5532

Vamsi Krishna Vasireddy
Principal Investigator

Indiana
Indianapolis

Indiana University/Melvin and Bren Simon Cancer Center

Theodore F. Logan
Ph: 317-274-2552

Theodore F. Logan
Principal Investigator

Michigan City

Franciscan Saint Anthony Health-Michigan City

Vamsi Krishna Vasireddy
Ph: 800-446-5532

Vamsi Krishna Vasireddy
Principal Investigator

Woodland Cancer Care Center

Vamsi Krishna Vasireddy
Ph: 800-446-5532

Vamsi Krishna Vasireddy
Principal Investigator

Mishawaka

Memorial Regional Cancer Center Day Road

Thomas Joseph Reid
Ph: 800-284-7370

Thomas Joseph Reid
Principal Investigator

Richmond

Reid Hospital and Health Care Services

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

South Bend

Memorial Hospital of South Bend

Thomas Joseph Reid
Ph: 800-284-7370

Thomas Joseph Reid
Principal Investigator

Iowa
Ames

Mary Greeley Medical Center

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

McFarland Clinic PC-William R Bliss Cancer Center

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Boone

McFarland Clinic PC-Boone

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Clive

Medical Oncology and Hematology Associates-West Des Moines

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Mercy Cancer Center-West Lakes

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Council Bluffs

Alegent Health Mercy Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Des Moines

Medical Oncology and Hematology Associates-Laurel

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Mercy Medical Center - Des Moines

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Fort Dodge

McFarland Clinic PC-Trinity Cancer Center

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Iowa City

University of Iowa/Holden Comprehensive Cancer Center

Daniel Alberto Vaena
Ph: 800-237-1225

Daniel Alberto Vaena
Principal Investigator

Jefferson

McFarland Clinic PC-Jefferson

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Marshalltown

McFarland Clinic PC-Marshalltown

Joseph James Merchant
Ph: 515-239-2621

Joseph James Merchant
Principal Investigator

Mason City

Mercy Medical Center - North Iowa

Arvind Y. Vemula
Ph: 800-433-3883

Arvind Y. Vemula
Principal Investigator

Sioux City

Siouxland Regional Cancer Center

Donald B. Wender
Ph: 712-252-0088

Donald B. Wender
Principal Investigator

West Des Moines

Mercy Medical Center-West Lakes

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Kansas
Topeka

Stormont-Vail Regional Health Center

David E. Einspahr
Ph: 785-270-4963

David E. Einspahr
Principal Investigator

Kentucky
Bardstown

Flaget Memorial Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Corbin

Commonwealth Cancer Center-Corbin

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Crestview Hills

Oncology Hematology Care Inc-Crestview

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Lexington

Saint Joseph Hospital East

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Saint Joseph Radiation Oncology Resource Center

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Louisville

Jewish Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Jewish Hospital Medical Center Northeast

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Saints Mary and Elizabeth Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Shepherdsville

Jewish Hospital Medical Center South

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Louisiana
Metairie

East Jefferson General Hospital

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Robert Veith MD LLC

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

New Orleans

Interim LSU Public Hospital

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Louisiana State University Health Science Center

Augusto C. Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Augusto C. Ochoa
Principal Investigator

Maryland
Baltimore

Johns Hopkins University/Sidney Kimmel Cancer Center

Hans-Joerg Hammers
Ph: 410-955-8804
Email: jhcccro@jhmi.edu

Hans-Joerg Hammers
Principal Investigator

Michigan
Ann Arbor

Saint Joseph Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

University of Michigan Comprehensive Cancer Center

Leonard Joseph Appleman
Ph: 412-647-8073
Email: applemanlj@upmc.edu

Leonard Joseph Appleman
Principal Investigator

Battle Creek

Bronson Battle Creek

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Clinton Township

Henry Ford Macomb Hospital

Robert Anthony Chapman
Ph: 313-916-1784

Robert Anthony Chapman
Principal Investigator

Dearborn

Henry Ford Medical Center-Fairlane

Robert Anthony Chapman
Ph: 313-916-1784

Robert Anthony Chapman
Principal Investigator

Oakwood Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Detroit

Henry Ford Hospital

Robert Anthony Chapman
Ph: 313-916-1784

Robert Anthony Chapman
Principal Investigator

Saint John Hospital and Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Flint

Genesys Hurley Cancer Institute

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Hurley Medical Center

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Grand Rapids

Mercy Health Saint Mary's

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Spectrum Health at Butterworth Campus

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Jackson

Allegiance Health

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Kalamazoo

West Michigan Cancer Center

Sunil Nagpal
Ph: 269-373-7458

Sunil Nagpal
Principal Investigator

Lansing

Sparrow Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Livonia

Saint Mary Mercy Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Muskegon

Mercy Health Mercy Campus

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Niles

Lakeland Community Hospital

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Novi

Henry Ford Medical Center-Columbus

Robert Anthony Chapman
Ph: 313-916-1784

Robert Anthony Chapman
Principal Investigator

Pontiac

Saint Joseph Mercy Oakland

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Port Huron

Saint Joseph Mercy Port Huron

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Reed City

Spectrum Health Reed City Hospital

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Saginaw

Saint Mary's of Michigan

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

Saint Joseph

Marie Yeager Cancer Center

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

St. Joseph

Lakeland Hospital

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Traverse City

Munson Medical Center

Gilbert D.A. Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Gilbert D.A. Padula
Principal Investigator

Trenton

Downriver Center for Oncology

Robert Anthony Chapman
Ph: 313-916-1784

Robert Anthony Chapman
Principal Investigator

Warren

Saint John Macomb-Oakland Hospital

Philip J. Stella
Ph: 734-712-4673

Philip J. Stella
Principal Investigator

West Bloomfield

Henry Ford Medical Center - West Bloomfield

Robert Anthony Chapman
Ph: 313-916-1784

Robert Anthony Chapman
Principal Investigator

Minnesota
Rochester

Mayo Clinic

Brian A. Costello
Ph: 507-538-7623

Brian A. Costello
Principal Investigator

Saint Cloud

Coborn Cancer Center at Saint Cloud Hospital

Donald James Jurgens
Ph: 877-229-4907
Email: coborncancercenter@centracare.com

Donald James Jurgens
Principal Investigator

Saint Cloud Hospital

Donald James Jurgens
Ph: 877-229-4907
Email: coborncancercenter@centracare.com

Donald James Jurgens
Principal Investigator

Mississippi
Jackson

University of Mississippi Medical Center

Louis Vincent Puneky
Ph: 601-815-6700

Louis Vincent Puneky
Principal Investigator

Missouri
Bonne Terre

Parkland Health Center-Bonne Terre

Alan P. Lyss
Ph: 800-392-0936

Alan P. Lyss
Principal Investigator

Cape Girardeau

Saint Francis Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Southeast Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Jefferson City

Capital Region Medical Center-Goldschmidt Cancer Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Saint Louis

Mercy Hospital Saint Louis

Bethany Graham Sleckman
Ph: 913-948-5588

Bethany Graham Sleckman
Principal Investigator

Missouri Baptist Medical Center

James Lloyd Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

James Lloyd Wade
Principal Investigator

Saint Louis Cancer and Breast Institute-South City

Bethany Graham Sleckman
Ph: 913-948-5588

Bethany Graham Sleckman
Principal Investigator

Saint Louis-Cape Girardeau CCOP

Bethany Graham Sleckman
Ph: 913-948-5588

Bethany Graham Sleckman
Principal Investigator

Washington University School of Medicine

Joel Picus
Ph: 800-600-3606
Email: info@siteman.wustl.edu

Joel Picus
Principal Investigator

Sainte Genevieve

Sainte Genevieve County Memorial Hospital

Alan P. Lyss
Ph: 800-392-0936

Alan P. Lyss
Principal Investigator

Sullivan

Missouri Baptist Sullivan Hospital

Alan P. Lyss
Ph: 800-392-0936

Alan P. Lyss
Principal Investigator

Sunset Hills

Missouri Baptist Outpatient Center-Sunset Hills

Alan P. Lyss
Ph: 800-392-0936

Alan P. Lyss
Principal Investigator

Montana
Billings

Billings Clinic Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Montana Cancer Consortium CCOP

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Saint Vincent Healthcare

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Bozeman

Bozeman Deaconess Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Butte

Saint James Community Hospital and Cancer Treatment Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Great Falls

Benefis Healthcare- Sletten Cancer Institute

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Helena

Saint Peter's Community Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Kalispell

Kalispell Regional Medical Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Missoula

Community Medical Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Saint Patrick Hospital - Community Hospital

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Nebraska
Grand Island

CHI Health Saint Francis

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Kearney

CHI Health Good Samaritan

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Heartland Hematology and Oncology

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Lincoln

Saint Elizabeth Regional Medical Center

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Omaha

Alegent Health Bergan Mercy Medical Center

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Alegent Health Immanuel Medical Center

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Alegent Health Lakeside Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Creighton University Medical Center

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Hemotology and Oncology Consultants PC

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Nebraska Methodist Hospital

Ralph J. Hauke
Ph: 402-354-5144

Ralph J. Hauke
Principal Investigator

Papillion

Midlands Community Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Nevada
Henderson

21st Century Oncology - Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada - Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada-Southeast Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Las Vegas Cancer Center-Henderson

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Las Vegas

21st Century Oncology

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

21st Century Oncology - Fort Apache

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

21st Century Oncology - Vegas Tenaya

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Fort Apache

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Shadow

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer and Blood Specialists-Tenaya

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Cancer Therapy and Integrative Medicine

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Children's Specialty Center of Nevada II

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada - Central Valley

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada - Northwest

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Comprehensive Cancer Centers of Nevada-Summerlin

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-San Martin

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

HealthCare Partners Medical Group Oncology/Hematology-Tenaya

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Las Vegas Cancer Center-Medical Center

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Nevada Cancer Research Foundation CCOP

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Radiation Oncology Centers of Nevada Central

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Radiation Oncology Centers of Nevada Southeast

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

Summerlin Hospital Medical Center

John Allan Ellerton
Ph: 702-384-0013

John Allan Ellerton
Principal Investigator

New Jersey
New Brunswick

Rutgers Cancer Institute of New Jersey

Eric Alan Singer
Ph: 732-235-8675

Eric Alan Singer
Principal Investigator

New York
Bronx

Albert Einstein College of Medicine

Benjamin Adam Gartrell
Ph: 718-904-2730
Email: aecc@aecom.yu.edu

Benjamin Adam Gartrell
Principal Investigator

Montefiore Medical Center - Moses Campus

Benjamin Adam Gartrell
Ph: 718-904-2730
Email: aecc@aecom.yu.edu

Benjamin Adam Gartrell
Principal Investigator

Montefiore Medical Center-Einstein Campus

Benjamin Adam Gartrell
Ph: 718-904-2730
Email: aecc@aecom.yu.edu

Benjamin Adam Gartrell
Principal Investigator

North Carolina
Asheboro

Randolph Hospital

James Mitchell Granfortuna
Ph: 336-832-0821

James Mitchell Granfortuna
Principal Investigator

Burlington

Cone Health Cancer Center at Alamance Regional

James Mitchell Granfortuna
Ph: 336-832-0821

James Mitchell Granfortuna
Principal Investigator

Clinton

Southeastern Medical Oncology Center-Clinton

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Goldsboro

Southeastern Medical Oncology Center-Goldsboro

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Wayne Memorial Hospital

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Greensboro

Cone Health Cancer Center

James Mitchell Granfortuna
Ph: 336-832-0821

James Mitchell Granfortuna
Principal Investigator

Jacksonville

Onslow Memorial Hospital

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Southeastern Medical Oncology Center-Jacksonville

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Kinston

Kinston Medical Specialists PA

Peter Robins Watson
Ph: 252-559-2200

Peter Robins Watson
Principal Investigator

Mebane

Cone Heath Cancer Center at Mebane

James Mitchell Granfortuna
Ph: 336-832-0821

James Mitchell Granfortuna
Principal Investigator

Reidsville

Annie Penn Memorial Hospital

James Mitchell Granfortuna
Ph: 336-832-0821

James Mitchell Granfortuna
Principal Investigator

Wilson

Southeastern Medical Oncology Center-Wilson

James N. Atkins
Ph: 919-580-0000

James N. Atkins
Principal Investigator

Ohio
Belpre

Strecker Cancer Center-Belpre

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Centerville

Miami Valley Hospital South

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Chillicothe

Adena Regional Medical Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Cincinnati

Bethesda North Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Good Samaritan Hospital - Cincinnati

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Oncology Hematology Care Inc - Anderson

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Oncology Hematology Care Inc - Kenwood

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Oncology Hematology Care Inc-Blue Ash

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Oncology Hematology Care Inc-Eden Park

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Oncology Hematology Care Inc-Mercy West

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

TriHealth Cancer Institute-Anderson

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

TriHealth Cancer Institute-Westside

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Columbus

Columbus Oncology and Hematology Associates Inc

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Doctors Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Grant Medical Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Mount Carmel Health Center West

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Riverside Methodist Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

The Mark H Zangmeister Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Dayton

Good Samaritan Hospital - Dayton

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Miami Valley Hospital

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Samaritan North Health Center

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Delaware

Delaware Health Center-Grady Cancer Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Delaware Radiation Oncology

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Grady Memorial Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Fairfield

Oncology Hematology Care Inc-Healthplex

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Findlay

Blanchard Valley Hospital

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Franklin

Atrium Medical Center-Middletown Regional Hospital

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Greenville

Wayne Hospital

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Kettering

Kettering Medical Center

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Lancaster

Fairfield Medical Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Marietta

Marietta Memorial Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Mount Vernon

Knox Community Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Newark

Licking Memorial Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Newark Radiation Oncology

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Portsmouth

Southern Ohio Medical Center

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Springfield

Springfield Regional Cancer Center

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Springfield Regional Medical Center

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Steubenville

Trinity's Tony Teramana Cancer Center

Leonard Joseph Appleman
Ph: 412-647-8073

Leonard Joseph Appleman
Principal Investigator

Sylvania

Flower Hospital

Jeffrey Henry Muler
Ph: 419-824-1842

Jeffrey Henry Muler
Principal Investigator

Troy

Upper Valley Medical Center

Howard M. Gross
Ph: 937-775-1350

Howard M. Gross
Principal Investigator

Westerville

Saint Ann's Hospital

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Zanesville

Genesis HealthCare System

John Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

John Philip Kuebler
Principal Investigator

Oklahoma
Lawton

Cancer Centers of Southwest Oklahoma Research

Nadim Fouad Nimeh
Ph: 877-231-4440

Nadim Fouad Nimeh
Principal Investigator

Oklahoma City

Mercy Hospital Oklahoma City

Vikki A. Canfield
Ph: 405-751-4343

Vikki A. Canfield
Principal Investigator

Oregon
Grants Pass

Three Rivers Community Hospital

Charles Robert Dibb
Ph: 541-789-6176

Charles Robert Dibb
Principal Investigator

Medford

Providence Medford Medical Center

Charles Robert Dibb
Ph: 541-789-6176

Charles Robert Dibb
Principal Investigator

Rogue Valley Medical Center

Charles Robert Dibb
Ph: 541-789-6176

Charles Robert Dibb
Principal Investigator

Portland

Oregon Health and Science University

Christopher W. Ryan
Ph: 503-494-1080
Email: trials@ohsu.edu

Christopher W. Ryan
Principal Investigator

Pennsylvania
Allentown

Lehigh Valley Hospital-Cedar Crest

Eliot L. Friedman
Ph: 610-402-2273

Eliot L. Friedman
Principal Investigator

Bethlehem

Lehigh Valley Hospital - Muhlenberg

Eliot L. Friedman
Ph: 610-402-2273

Eliot L. Friedman
Principal Investigator

Philadelphia

University of Pennsylvania/Abramson Cancer Center

Naomi Susanne Balzer-Haas
Ph: 800-474-9892

Naomi Susanne Balzer-Haas
Principal Investigator

Pittsburgh

University of Pittsburgh Cancer Institute (UPCI)

Leonard Joseph Appleman
Ph: 412-647-8073

Leonard Joseph Appleman
Principal Investigator

Pottstown

Pottstown Memorial Medical Center

Wei (Frank) Song
Ph: 610-327-7544

Wei (Frank) Song
Principal Investigator

South Carolina
Greenville

Saint Francis Cancer Center

Robert D. Siegel
Ph: 864-255-1713

Robert D. Siegel
Principal Investigator

Saint Francis Hospital

Robert D. Siegel
Ph: 864-255-1713

Robert D. Siegel
Principal Investigator

South Dakota
Rapid City

Rapid City Regional Hospital

Joshua Cole Lukenbill
Ph: 605-716-3982
Email: research@rcrh.org

Joshua Cole Lukenbill
Principal Investigator

Tennessee
Bristol

Wellmont Bristol Regional Medical Center

Asheesh Shipstone
Ph: 423-578-8538

Asheesh Shipstone
Principal Investigator

Wellmont Medical Associates Oncology and Hematology-Bristol

Asheesh Shipstone
Ph: 423-578-8538

Asheesh Shipstone
Principal Investigator

Chattanooga

Memorial Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Hixson

Pulmonary Medicine Center of Chattanooga-Hixson

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Kingsport

Wellmont Holston Valley Hospital and Medical Center

Asheesh Shipstone
Ph: 423-578-8538

Asheesh Shipstone
Principal Investigator

Wellmont Medical Associates Oncology and Hematology-Kingsport

Asheesh Shipstone
Ph: 423-578-8538

Asheesh Shipstone
Principal Investigator

Knoxville

University of Tennessee - Knoxville

Wahid T. Hanna
Ph: 865-544-9773

Wahid T. Hanna
Principal Investigator

Ooltewah

Memorial GYN Plus

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Utah
Salt Lake City

Huntsman Cancer Institute/University of Utah

Junfeng Wang
Ph: 801-581-4477
Email: clinical.trials@hci.utah.edu

Junfeng Wang
Principal Investigator

Virginia
Midlothian

Bon Secours Saint Francis Medical Center

William Johnson Irvin
Ph: 804-594-4900

William Johnson Irvin
Principal Investigator

Norton

Southwest VA Regional Cancer Center

Asheesh Shipstone
Ph: 423-578-8538

Asheesh Shipstone
Principal Investigator

Richmond

Bon Secours Saint Mary's Hospital

William Johnson Irvin
Ph: 804-594-4900

William Johnson Irvin
Principal Investigator

Washington
Auburn

MultiCare Auburn Medical Center

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Bainbridge Island

Virginia Mason Bainbridge Island Medical Center

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Bellevue

Overlake Hospital Medical Center

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Bremerton

Harrison HealthPartners Hematology and Oncology-Bremerton

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Harrison Medical Center

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Burien

Highline Medical Center-Main Campus

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Enumclaw

Saint Elizabeth Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Federal Way

Saint Francis Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Virginia Mason Federal Way Medical Center

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Gig Harbor

MultiCare Gig Harbor Medical Park

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Tacoma/Valley Radiation Oncology Centers-Gig Harbor

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Kennewick

Northwest Cancer Clinic

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Lakewood

Saint Clare Hospital

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Lynnwood

Virginia Mason Lynnwood Medical Center

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Poulsbo

Harrison HealthPartners Hematology and Oncology-Poulsbo

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Peninsula Cancer Center

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Puyallup

MultiCare Good Samaritan Hospital

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Tacoma/Valley Radiation Oncology Centers-Puyallup

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Seattle

Virginia Mason Medical Center

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Tacoma

Franciscan Research Center-Northwest Medical Plaza

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Multicare Health System

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Northwest Medical Specialties PLLC

Mehmet Sitki Copur
Ph: 800-998-2119

Mehmet Sitki Copur
Principal Investigator

Tacoma/Valley Radiation Oncology Centers-Jackson Hall

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

Tacoma/Valley Radiation Oncology Centers-Saint Joe's

John A. Keech
Ph: 907-458-5380

John A. Keech
Principal Investigator

West Virginia
Charleston

West Virginia University Charleston

Steven James Jubelirer
Ph: 304-344-3457

Steven James Jubelirer
Principal Investigator

Princeton

Princeton Community Hospital

Rowena Gonzales-Chambers
Ph: 304-487-7000

Rowena Gonzales-Chambers
Principal Investigator

Wisconsin
Burlington

Aurora Cancer Care-Burlington

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Chippewa Falls

Marshfield Clinic-Chippewa Center

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Eau Claire

Marshfield Clinic Cancer Center at Sacred Heart

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Sacred Heart Hospital

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Elkhorn

Aurora Cancer Care-Southern Lakes

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Fond Du Lac

Aurora Health Center-Fond du Lac

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Grafton

Aurora Cancer Care-Grafton

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Green Bay

Aurora BayCare Medical Center

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Kenosha

Aurora Cancer Care-Kenosha South

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

La Crosse

Gundersen Lutheran Medical Center

Kurt Oettel
Ph: 608-775-2385
Email: cancerctr@gundluth.org

Kurt Oettel
Principal Investigator

Ladysmith

Marshfield Clinic - Ladysmith Center

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Marinette

Vince Lombardi Cancer Clinic-Marinette

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Marshfield

Marshfield Clinic

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Saint Joseph's Hospital

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Menomonee Falls

Aurora Advanced Healthcare Inc-Menomonee Falls

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Milwaukee

Aurora Cancer Care-Milwaukee

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Aurora Saint Luke's Medical Center

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Aurora Sinai Medical Center

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Froedtert and the Medical College of Wisconsin

Kathryn A. Bylow
Ph: 414-805-4380

Kathryn A. Bylow
Principal Investigator

Wheaton Franciscan Healthcare - Saint Joseph

Jonathan Scott Treisman
Ph: 414-427-2360

Jonathan Scott Treisman
Principal Investigator

Minocqua

Marshfield Clinic-Minocqua Center

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Mukwonago

D N Greenwald Center

Timothy Robert Wassenaar
Ph: 262-928-5539
Email: Chanda.miller@phci.org

Timothy Robert Wassenaar
Principal Investigator

Oconomowoc

Oconomowoc Memorial Hospital-ProHealth Care Inc

Timothy Robert Wassenaar
Ph: 262-928-5539
Email: Chanda.miller@phci.org

Timothy Robert Wassenaar
Principal Investigator

Oshkosh

Vince Lombardi Cancer Clinic - Oshkosh

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Racine

Aurora Cancer Care-Racine

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Rhinelander

Marshfield Clinic at James Beck Cancer Center

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Saint Mary's Hospital

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Rice Lake

Lakeview Medical Center-Marshfield Clinic

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Marshfield Clinic-Rice Lake Center

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Sheboygan

Vince Lombardi Cancer Clinic-Sheboygan

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Stevens Point

Marshfield Clinic Cancer Care at Saint Michael's Hospital

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Saint Michael's Hospital

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Summit

Aurora Medical Center in Summit

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Two Rivers

Vince Lombardi Cancer Clinic

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Waukesha

Aurora Cancer Care-Waukesha

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Waukesha Memorial Hospital

Timothy Robert Wassenaar
Ph: 262-928-5539
Email: Chanda.miller@phci.org

Timothy Robert Wassenaar
Principal Investigator

Wausau

Marshfield Clinic-Wausau Center

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Wauwatosa

Aurora Cancer Care-Milwaukee West

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

West Allis

Aurora West Allis Medical Center

Rubina Qamar
Ph: 888-709-2080

Rubina Qamar
Principal Investigator

Weston

Diagnostic and Treatment Center

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Marshfield Clinic - Weston Center

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Saint Clare's Hospital

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Wisconsin Rapids

Marshfield Clinic - Wisconsin Rapids Center

Seth Olusegun Fagbemi
Ph: 715-389-4457

Seth Olusegun Fagbemi
Principal Investigator

Wyoming
Cody

Big Horn Basin Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Billings Clinic-Cody

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Sheridan

Welch Cancer Center

Benjamin T. Marchello
Ph: 800-648-6274

Benjamin T. Marchello
Principal Investigator

Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01575548

Note: Information about participating sites on pharmaceutical industry trials may be incomplete. Please visit the ClinicalTrials.gov record via the link above for more information about participating sites.