Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer

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Basic Trial Information

PhaseTypeStatusAgeSponsorProtocol IDs
Phase IIISupportive care, TreatmentActive18 and overNCI, OtherANZGOG-0902/GOG-0274/RTOG-1174
NCI-2011-02978, CDR0000706698, GOG-0274, RTOG-1174, ANZGOG-0902, ANZGOG-0902-GOG-0274, U10CA027469, NCT01414608

Trial Description

Summary

This randomized phase III trial studies how well giving cisplatin and radiation therapy together with or without carboplatin and paclitaxel works in treating patients with locally advanced cervical cancer. Drugs used in chemotherapy, such as cisplatin, carboplatin, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. External radiation therapy uses high-energy x rays to kill tumor cells. Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. It is not yet known whether giving cisplatin and external and internal radiation therapy together with carboplatin and paclitaxel kills more tumor cells.

Further Study Information

PRIMARY OBJECTIVES:

I. To determine if the addition of adjuvant chemotherapy to standard cisplatin-based chemoradiation improves overall survival.

SECONDARY OBJECTIVES:

I. To determine the progression-free survival rates. II. To determine acute and long-term toxicities. III. To determine patterns of disease recurrence. IV. To determine the association between radiation protocol compliance and outcomes.

V. To determine patient quality of life, including psycho-sexual health.

TERTIARY OBJECTIVES:

I. To determine the association between the results of a follow-up positron emission tomography (PET) scan performed 4-6 months post completion of chemoradiation and outcomes for all patients in the trial.

II. To determine the biological predictors of patients' outcomes based on translational laboratory studies of blood and tissue specimens.

OUTLINE: This is a multicenter study. Patients are stratified according to pelvic or common iliac nodal involvement (yes vs no), requirement for extended-field radiotherapy treatment (yes vs no), International Federation of Gynecology and Obstetrics (FIGO) stage (IB/IIA vs IIB vs IIIB/IVA), age (< 60 years of age vs >= 60 years of age), and hospital/site. Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive cisplatin intravenously (IV) over 60-90 minutes on days 1, 8, 15, 22, and 29. Patients also undergo external-beam radiation therapy once daily, 5 days a week, for approximately 5 weeks. Patients then undergo high-dose rate, pulsed-dose rate, or low-dose rate intracavitary brachytherapy.

ARM II: Patients receive cisplatin and undergo external-beam radiation and brachytherapy as in arm I. Beginning 4 weeks later, patients also receive adjuvant chemotherapy comprising paclitaxel IV over 3 hours and carboplatin IV over 1 hour on day 1. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.

Patients may undergo baseline tumor biopsy and blood collection for future correlative studies.

Patients complete the European Organization for Research and Treatment of Cancer (EORTC) Core questionnaire (QLQ-C30), the EORTC cervix cancer module (CX24), the ovarian cancer module (OV28), and the Sexual function-Vaginal Changes Questionnaire (SVQ) questionnaires at baseline, during, and after completion of study treatment.

After completion of study therapy, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Eligibility Criteria

Inclusion Criteria:

  • Eligible patients will have locally advanced cervical cancer suitable for primary treatment with chemoradiation with curative intent, in addition to:
  • Histological diagnosis of squamous cell carcinoma, adenocarcinoma, or adenosquamous cell carcinoma of the cervix
  • FIGO 2008 stage IB1 & node positive, IB2, II, IIIB, or IVA disease
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • Histological diagnosis of squamous cell carcinoma, adenocarcinoma or adenosquamous cell carcinoma of the cervix
  • White blood cells (WBC) >= 3.0 x 10^9/L
  • Absolute neutrophil count (ANC) >= 1.5 x 10^9/L
  • Platelet count >= 100 x 10^9/L
  • Bilirubin =< 1.5 times upper limit of normal (ULN)
  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2.5 x ULN
  • Creatinine =< ULN (Common Toxicity Criteria [CTC] Grade 0) OR calculated creatinine clearance (Cockcroft-Gault Formula) >= 60 mL/min OR >= 50 mL/min by ethylenediaminetetraacetic acid (EDTA) creatinine clearance
  • Written informed consent

Exclusion Criteria:

  • Any previous pelvic radiotherapy
  • Para-aortic nodal involvement above the level of the common iliac nodes or L3/L4 (if biopsy proven, PET positive, or >= 15 mm short-axis diameter on computed tomography [CT])
  • FIGO 2008 stage IIIA disease
  • Patients assessed at presentation as requiring interstitial brachytherapy treatment
  • Patients with bilateral hydronephrosis unless at least one side has been stented and renal function fulfills the required inclusion criteria
  • Previous chemotherapy for this tumor
  • Evidence of distant metastases
  • Prior diagnosis of Crohn disease or ulcerative colitis
  • Peripheral neuropathy >= grade 2 (per Common Terminology Criteria for Adverse Events [CTCAE] v. 4)
  • Patients who have undergone a previous hysterectomy or will have a hysterectomy as part of their initial cervical cancer therapy
  • Patients with other invasive malignancies, with the exception of non-melanoma skin cancer and in situ melanoma, who had (or have) any evidence of the other cancer present within the last 5 years
  • Patients who are pregnant or lactating
  • Any contraindication to the use of cisplatin, carboplatin, or paclitaxel chemotherapy
  • Serious illness or medical condition that precludes the safe administration of the trial treatment including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
  • Human immunodeficiency virus (HIV) positive

Trial Contact Information

Trial Lead Organizations/Sponsors

Gynecologic Oncology Group

  • National Cancer Institute
Kathleen Moore, Principal Investigator

Trial Sites

U.S.A.

Alabama
Birmingham

UAB Comprehensive Cancer Center

Warner Huh
Ph: 205-934-0309

Mobile

University of South Alabama Mitchell Cancer Institute

Rodney P Rocconi
Ph: 251-445-9870
Email: pfrancisco@usouthal.edu

Arizona
Phoenix

Arizona Oncology Associates - Biltmore Cancer Center

Michael A. Bookman
Ph: 520-626-9008

GOG of Arizona, PC

Kathleen N Moore
Ph: 405-271-8707
Email: lreese@gog.org

St. Joseph's Hospital and Medical Center

John H Farley
Ph: 877-602-4111

Arkansas
Little Rock

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

Kristin K Zorn
Ph: 501-686-8274

California
Concord

Cancer Care Center at John Muir Health - Concord Campus

Babak Edraki
Ph: 925-674-2580

Fremont

Kaiser Permanente - Fremont

Tatjana Kolevska
Ph: 626-564-3455

Mountain View

Palo Alto Medical Foundation

John K Chan
Ph: 415-209-2686
Email: bernicl@sutterhealth.org

Oakland

Kaiser Permanente-Oakland

Tatjana Kolevska
Ph: 626-564-3455

Orange

Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center

Krishnansu S Tewari
Ph: 714-456-6191
Email: awallick@uci.edu

St. Joseph Hospital Regional Cancer Center - Orange

Michael L Berman
Ph: 877-827-8839
Email: ucstudy@uci.edu

Roseville

Kaiser Permanente Medical Center - Roseville

Tatjana Kolevska
Ph: 626-564-3455

Sacramento

University of California Davis Cancer Center

Gary Leiserowitz
Ph: 916-734-3089

San Francisco

Kaiser Permanente Medical Center - San Francisco Geary Campus

Tatjana Kolevska
Ph: 626-564-3455

Sylmar

Olive View - UCLA Medical Center Foundation

Christine Holschneider
Ph: 888-798-0719

Vallejo

Kaiser Permanente Medical Center - Vallejo

Tatjana Kolevska
Ph: 626-564-3455

Walnut Creek

John Muir/Mt. Diablo Comprehensive Cancer Center

Babak Edraki
Ph: 925-674-2580

Colorado
Aurora

Medical Center of Aurora - South Campus

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers - Aurora

Keren Sturtz
Ph: 888-785-6789

University of Colorado Cancer Center at UC Health Sciences Center

Susan Davidson
Ph: 720-848-0650

Boulder

Boulder Community Hospital

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers-Boulder

Keren Sturtz
Ph: 888-785-6789

Colorado Springs

Rocky Mountain Cancer Centers at the Pavilion

Keren Sturtz
Ph: 888-785-6789

Denver

CCOP - Colorado Cancer Research Program

Keren Sturtz
Ph: 888-785-6789

Colorado Blood Cancer Institute

Keren Sturtz
Ph: 888-785-6789

Porter Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Presbyterian - St. Luke's Medical Center

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers - Denver Midtown

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers-Rose

Keren Sturtz
Ph: 888-785-6789

Rose Medical Center

Keren Sturtz
Ph: 888-785-6789

St. Joseph Hospital

Keren Sturtz
Ph: 888-785-6789

Durango

Southwest Oncology, PC

Keren Sturtz
Ph: 888-785-6789

Englewood

Comprehensive Cancer Care and Research Institute of Colorado LLC

Keren Sturtz
Ph: 888-785-6789

Swedish Medical Center

Keren Sturtz
Ph: 888-785-6789

Greeley

North Colorado Medical Center

Keren Sturtz
Ph: 888-785-6789

Greenwood Village

Breast Cancer Care Consultants

Keren Sturtz
Ph: 888-785-6789

Lakewood

Rocky Mountain Cancer Centers-Lakewood

Keren Sturtz
Ph: 888-785-6789

St. Anthony Central Hospital

Keren Sturtz
Ph: 888-785-6789

Littleton

Littleton Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers - Littleton

Keren Sturtz
Ph: 888-785-6789

Lone Tree

Rocky Mountain Cancer Centers - Lone Tree

Keren Sturtz
Ph: 888-785-6789

Sky Ridge Medical Center

Keren Sturtz
Ph: 888-785-6789

Longmont

Hope Cancer Care Center at Longmont United Hospital

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers - Longmont

Keren Sturtz
Ph: 888-785-6789

Loveland

McKee Medical Center

Keren Sturtz
Ph: 888-785-6789

Parker

Parker Adventist Hospital

Keren Sturtz
Ph: 888-785-6789

Rocky Mountain Cancer Centers - Parker

Keren Sturtz
Ph: 888-785-6789

Pueblo

Rocky Mountain Cancer Centers - Pueblo

Keren Sturtz
Ph: 888-785-6789

St. Mary - Corwin Regional Medical Center

Keren Sturtz
Ph: 888-785-6789

Thornton

Rocky Mountain Cancer Centers - Thornton

Keren Sturtz
Ph: 888-785-6789

Wheat Ridge

Exempla Lutheran Medical Center

Keren Sturtz
Ph: 888-785-6789

Connecticut
Farmington

Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center

Angela S Kueck
Ph: 800-579-7822

New Haven

Yale Cancer Center

Peter E. Schwartz
Ph: 203-785-5702

Florida
Deerfield Beach

University of Miami/Deerfield Beach

Aaron H Wolfson
Ph: 866-574-5124
Email: Sylvester@emergingmed.com

Miami

Jackson Memorial Hospital

Aaron H Wolfson
Ph: 866-574-5124
Email: Sylvester@emergingmed.com

University of Miami Sylvester Comprehensive Cancer Center - Miami

Aaron H Wolfson
Ph: 866-574-5124
Email: Sylvester@emergingmed.com

Orlando

M.D. Anderson Cancer Center at Orlando

Kathleen N Moore
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Georgia
Atlanta

Georgia Cancer Center for Excellence at Grady Memorial Hospital

Joseph W Shelton
Ph: 404-489-9164

Northside Hospital Cancer Center

Sahar E Rosenbaum
Ph: 404-303-3355

Winship Cancer Institute of Emory University

Joseph W Shelton
Ph: 404-489-9164

Gainesville

Northeast Georgia Medical Center

Andrew E Green
Ph: 770-219-8800
Email: cancerpatient.navigator@nghs.com

Hawaii
Honolulu

Cancer Research Center of Hawaii

Michael E. Carney
Ph: 808-983-6090

Kaiser Permanente - Moanalua Medical Center and Clinic

Tatjana Kolevska
Ph: 626-564-3455

Kapiolani Medical Center for Women and Children

Michael E. Carney
Ph: 808-983-6090

Queen's Cancer Institute at Queen's Medical Center

Michael E. Carney
Ph: 808-983-6090

Illinois
Bloomington

Illinois CancerCare - Bloomington

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

St. Joseph Medical Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Canton

Illinois CancerCare - Canton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Carthage

Illinois CancerCare - Carthage

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Chicago

John H. Stroger, Jr. Hospital of Cook County

Thomas E. Lad
Ph: 312-864-6000

Robert H. Lurie Comprehensive Cancer Center at Northwestern University

Eric D Donnelly
Ph: 312-695-1301
Email: cancer@northwestern.edu

University of Chicago Cancer Research Center

Meaghan E Tenney
Ph: 773-834-7424

Eureka

Illinois CancerCare - Eureka

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Galesburg

Galesburg Clinic, PC

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

InterCommunity Cancer Center of Western Illinois

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Hinsdale

Gynecologic Oncology

Sudarshan K. Sharma
Ph: 630-856-6757

Kewanee

Illinois CancerCare - Kewanee Clinic

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Macomb

Illinois CancerCare - Macomb

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Maywood

Cardinal Bernardin Cancer Center at Loyola University Medical Center

William Small
Ph: 708-226-4357

Ottawa

Illinois CancerCare - Ottawa

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Pekin

Cancer Treatment Center at Pekin Hospital

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Peoria

Illinois CancerCare - Peoria

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Methodist Medical Center of Illinois

Nguyet A Le-Lindqwister
Ph: 800-793-2262

OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

Nguyet A Le-Lindqwister
Ph: 800-793-2262

OSF St. Francis Medical Center

Nguyet A Le-Lindqwister
Ph: 800-793-2262

Peru

Illinois CancerCare - Princeton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Valley Cancer Center

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Princeton

Illinois CancerCare - Princeton

James L. Wade
Ph: 217-876-4740
Email: kcheek@dmhhs.org

Indiana
Elkhart

Michiana Hematology-Oncology, PC - Elkhart

Kathleen N Moore
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Indianapolis

St. Vincent Oncology Center

Michael J Callahan
Ph: 317-338-2194
Email: research@stvincent.org

Mishawaka

Saint Joseph's Medical Center

Kathleen N Moore
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Iowa
Iowa City

Holden Comprehensive Cancer Center at University of Iowa

David P Bender
Ph: 800-237-1225

Kansas
Kansas City

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center

Julia A. Chapman
Ph: 913-588-4709

Kentucky
Lexington

Central Baptist Hospital

Hope M Cottrill
Ph: 859-260-6425

University of Kentucky Chandler Medical Center

Frederick Ueland
Ph: 859-257-3379

Louisiana
New Orleans

Ochsner Cancer Institute at Ochsner Clinic Foundation

Richard C. Kline
Ph: 888-562-4763

Stanley S. Scott Cancer Center at Louisiana State University Medical Center - New Orleans

Augusto C Ochoa
Ph: 504-568-2428
Email: emede1@lsuhsc.edu

Tulane Cancer Center at Tulane University Hospital and Clinic

William R. Robinson
Ph: 504-988-6121

Maryland
Baltimore

Greenebaum Cancer Center at University of Maryland Medical Center

Gautam G Rao
Ph: 800-888-8823

Bethesda

National Naval Medical Center

Michael P Stany
Ph: 301-319-2100

Massachusetts
Springfield

Baystate Medical Center

Tashanna K Myers
Ph: 413-794-3565
Email: tamara.wrenn@baystatehealth.org

Michigan
Battle Creek

Battle Creek Health System Cancer Care Center

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Detroit

Josephine Ford Cancer Center at Henry Ford Hospital

Thomas E Buekers
Ph: 313-916-1784

Wayne State University

Robert T. Morris
Ph: 313-576-9363

Grand Rapids

Butterworth Hospital at Spectrum Health

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Lacks Cancer Center at Saint Mary's Health Care

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Kalamazoo

West Michigan Cancer Center

Sunil Nagpal
Ph: 269-373-7458

Royal Oak

William Beaumont Hospital - Royal Oak Campus

Jayson B Field
Ph: 248-551-7695

Traverse City

Munson Medical Center

Gilbert D Padula
Ph: 616-685-5225
Email: connie.szczepanek@grcop.org

Minnesota
Minneapolis

Masonic Cancer Center at University of Minnesota

Peter A Argenta
Ph: 612-624-2620

Woodbury

Minnesota Oncology - Woodbury

Matthew P Boente
Ph: 952-993-1517
Email: MMCCOP@parknicollet.com

Mississippi
Jackson

University of Mississippi Cancer Clinic

James Tate Thigpen
Ph: 601-815-6700

Missouri
Springfield

Hulston Cancer Center at Cox Medical Center South

Jay W Carlson
Ph: 800-821-7532

St. John's Regional Health Center

Jay W Carlson
Ph: 800-821-7532

Nebraska
Omaha

Fred and Pamela Buffett Cancer Center

Kerry Rodabaugh
Ph: 402-559-6941
Email: unmcrsa@unmc.edu

Methodist Estabrook Cancer Center

Peter C. Morris
Ph: 402-354-7939
Email: kathryn.bartz@nmhs.org

Nevada
Las Vegas

Women's Cancer Center - La Canada

Nick M. Spirtos
Ph: 702-851-4672

New Hampshire
Dover

Seacoast Cancer Center at Wentworth - Douglass Hospital

John Schorge
Ph: 877-726-5130

New Jersey
Camden

Cancer Institute of New Jersey at Cooper University Hospital - Camden

David P. Warshal
Ph: 856-325-6757

Hackensack

Hackensack University Medical Center Cancer Center

Donna T McNamara
Ph: 201-996-2879

Morristown

Carol G. Simon Cancer Center at Morristown Memorial Hospital

Yana P Goldberg
Ph: 973-971-5900

Neptune

Jersey Shore Cancer Center at Jersey Shore University Medical Center

Karim S ElSahwi
Ph: 732-776-4240

New Brunswick

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School

Darlene G. Gibbon
Ph: 732-235-8675

New Mexico
Albuquerque

Southwest Gynecologic Oncology Associates, Incorporated

Teresa L Rutledge
Ph: 505-272-6972

University of New Mexico Cancer Center

Teresa L Rutledge
Ph: 505-272-6972

Kathleen N Moore
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

New York
Brooklyn

New York Methodist Hospital

Katherine Economos
Ph: 718-780-5240

Buffalo

Roswell Park Cancer Institute

Peter J Frederick
Ph: 877-275-7724

Manhasset

Don Monti Comprehensive Cancer Center at North Shore University Hospital

Veena S John
Ph: 516-562-3467

Mineola

Winthrop University Hospital

Eva Chalas
Ph: 866-946-8476

New Hyde Park

Long Island Jewish Medical Center

Veena S John
Ph: 516-562-3467

Monter Cancer Center of the North Shore-LIJ Health System

Veena S John
Ph: 516-562-3467

New York

Memorial Sloan-Kettering Cancer Center

Mario M Leitao
Ph: 212-639-7202

New York University Medical Center

Stephanie V. Blank
Ph: 212-263-4434
Email: prmc.coordinator@nyumc.org

Stony Brook

Stony Brook University Cancer Center

Michael L. Pearl
Ph: 800-862-2215

North Carolina
Burlington

Alamance Cancer Center at Alamance Regional Medical Center

Janak K. Choksi
Ph: 336-538-7725

Charlotte

Blumenthal Cancer Center at Carolinas Medical Center

Robert Victor Higgins
Ph: 704-355-2884

Concord

Batte Cancer Center at Northeast Medical Center

Brigitte E. Miller
Ph: 704-403-1520

Ohio
Akron

Summa Center for Cancer Care at Akron City Hospital

Vivian von Gruenigen
Ph: 330-375-6101

Cleveland

Cleveland Clinic Cancer Center at Fairview Hospital

Peter Graham Rose
Ph: 866-223-8100

Cleveland Clinic Taussig Cancer Center

Peter Graham Rose
Ph: 866-223-8100

MetroHealth Cancer Care Center at MetroHealth Medical Center

Peter Graham Rose
Ph: 866-223-8100

Columbus

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

David M O'Malley
Ph: 800-293-5066
Email: Jamesline@osumc.edu

Riverside Methodist Hospital Cancer Care

J. Philip Kuebler
Ph: 614-488-2745
Email: sheree@columbusccop.org

Dayton

David L. Rike Cancer Center at Miami Valley Hospital

Howard M. Gross
Ph: 937-775-1350

Kettering

Charles F. Kettering Memorial Hospital

Howard M. Gross
Ph: 937-775-1350

Mayfield Heights

Hillcrest Cancer Center at Hillcrest Hospital

Peter Graham Rose
Ph: 866-223-8100

Toledo

University of Toledo Medical Center

Rex B Mowat
Ph: 800-444-3561

Oklahoma
Oklahoma City

Stephenson Cancer Center at the University of Oklahoma

Robert S. Mannel
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Tulsa

Cancer Care Associates-Yale

Robert S. Mannel
Ph: 405-271-4272
Email: julie-traylor@ouhsc.edu

Pennsylvania
Abington

Rosenfeld Cancer Center at Abington Memorial Hospital

Parviz Hanjani
Ph: 215-481-2402

Bethlehem

St. Luke's Cancer Network at St. Luke's Hospital

Nicholas P Taylor
Ph: 610-954-3582
Email: infolink@slhn.org

Philadelphia

Abramson Cancer Center of the University of Pennsylvania

Robert A. Burger
Ph: 215-746-7406

Drexel University College of Medicine - Center City Hahnemann Campus

Scott D Richard
Ph: 866-884-4484

Gynecologic Oncology Group

Philip J. DiSaia
Ph: 215-854-0770
Email: lreese@gog.org

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

Pramila Rani Anne
Ph: 215-955-6084

Pittsburgh

UPMC - Shadyside

Dwight E Heron
Ph: 412-647-8073

UPMC Cancer Center at Magee-Womens Hospital

Dwight E Heron
Ph: 412-647-8073

West Reading

McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

Bernice L Robinson-Bennett
Ph: 610-988-9323

Rhode Island
Providence

Women and Infants Hospital of Rhode Island

Paul A. DiSilvestro
Ph: 401-274-1122

South Carolina
Anderson

AnMed Cancer Center

David Griffin
Ph: 864-512-1000

Charleston

Hollings Cancer Center at Medical University of South Carolina

Jennifer L Young Pierce
Ph: 843-792-9321

Greenville

Bon Secours St. Francis Health System

David Griffin
Ph: 864-512-1000

Spartanburg

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

David Griffin
Ph: 864-512-1000

South Dakota
Rapid City

Black Hills Obstetrics & Gynecology LLP

Helen L. Frederickson
Ph: 605-343-9224

Rapid City Regional Hospital

Helen L. Frederickson
Ph: 605-343-9224

Texas
Austin

Texas Oncology - Midtown Austin

Michael A. Bookman
Ph: 520-626-9008

Texas Oncology, PA at South Austin Cancer Center

Michael A. Bookman
Ph: 520-626-9008

Texas Oncology, PA at Texas Oncology Cancer Center - Central

Michael A. Bookman
Ph: 520-626-9008

Bedford

Texas Oncology, PA at Harris Center HEB

Michael A. Bookman
Ph: 520-626-9008

Dallas

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

David Scott Miller
Ph: 214-648-7097

Texas Oncology, PA at Charles A. Sammons Cancer Center

Michael A. Bookman
Ph: 520-626-9008

Fort Worth

Texas Oncology, PA - Fort Worth

Michael A. Bookman
Ph: 520-626-9008

Houston

Lyndon B. Johnson General Hospital

Lois M. Ramondetta
Ph: 713-792-3245

M. D. Anderson Cancer Center at University of Texas

Lois M. Ramondetta
Email: lramonde@mdanderson.org

Memorial Hermann - Texas Medical Center

Anthony Lucci
Ph: 866-574-5124
Email: Sylvester@emergingmed.com

Methodist Hospital

Aparna A Kamat
Ph: 713-790-2700

Univeristy of Texas M.D. Anderson Cancer Center

Lois M. Ramondetta
Ph: 713-792-3245

Utah
Murray

Jon and Karen Huntsman Cancer Center at Intermountain Medical Center

R. Jeffrey Lee
Ph: 801-507-3950

Saint George

Dixie Regional Medical Center - East Campus

R. Jeffrey Lee
Ph: 801-507-3950

Salt Lake City

Huntsman Cancer Institute at University of Utah

Matthew M Poppe
Ph: 801-581-4477
Email: clinical.trials@hci.utah.edu

LDS Hospital

R. Jeffrey Lee
Ph: 801-507-3950

Utah Cancer Specialists at UCS Cancer Center

R. Jeffrey Lee
Ph: 801-507-3950

Virginia
Charlottesville

University of Virginia Cancer Center

Susan C Modesitt
Ph: 434-243-6143

Richmond

Virginia Commonwealth University Massey Cancer Center

Weldon E Chafe
Ph: 804-628-1939

Roanoke

Carilion Clinic Gynecological Oncology

Janet L. Osborne
Ph: 540-985-8510

Wisconsin
Green Bay

Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center

Ali Mahdavi
Ph: 414-649-5717

Madison

University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

Kristin Ann Bradley
Ph: 877-405-6866

Milwaukee

Froedtert Hospital and Medical College of Wisconsin

William H Bradley
Ph: 414-805-4380

Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

Ali Mahdavi
Ph: 414-649-5717

Oshkosh

Vince Lombardi Cancer Clinic - Oshkosh

Ali Mahdavi
Ph: 414-649-5717

Wyoming
Cheyenne

Cheyenne Regional Medical Center

Keren Sturtz
Ph: 888-785-6789

Canada

Ontario
Hamilton

Margaret and Charles Juravinski Cancer Centre

Lorraine (Laurie) M Elit
Ph: 905-387-9495

London

London Regional Cancer Program at London Health Sciences Centre

David P. D'Souza
Ph: 519-685-8600

Toronto

Princess Margaret Hospital

Anthony W Fyles
Ph: 416-946-4501
Email: clinical.trials@uhn.on.ca

Quebec
Montreal

Hopital Notre-Dame du CHUM

Maroie Barkati
Ph: 514-890-8000ext23611
Email: sylvie.beaudoin.chum@ssss.gouv.qc.ca

Saskatchewan
Regina

Allan Blair Cancer Centre at Pasqua Hospital

Evgeny Sadikov
Ph: 306-766-2213

Saudi Arabia

Riyadh

King Faisal Specialist Hospital and Research Center

Hamed H Al-Husaini
Ph: 011-966-1-464-7272 ext 38005

Link to the current ClinicalTrials.gov record.
NLM Identifier NCT01414608
ClinicalTrials.gov processed this data on May 20, 2015

Note: Information about this trial is from the ClinicalTrials.gov database. The versions designated for health professionals and patients contain the same text. Minor changes may be made to the ClinicalTrials.gov record to standardize the names of study sponsors, sites, and contacts. Cancer.gov only lists sites that are recruiting patients for active trials, whereas ClinicalTrials.gov lists all sites for all trials. Questions and comments regarding the presented information should be directed to ClinicalTrials.gov.