Study of Antiangiogenic Therapy for Kidney Cancer
Name of the Trial
Why Is This Trial Important?
Interferon alfa-2b is a standard initial treatment for advanced kidney cancer and may have an antitumor effect via multiple mechanisms. In addition to stimulation of the immune system, interferon may decrease blood vessel formation to tumors, a process called angiogenesis. Adding another antiangiogenic agent such as bevacizumab (Avastin™) may improve the effectiveness of this initial kidney cancer treatment. Bevacizumab is an antibody that attaches to and neutralizes vascular endothelial growth factor (VEGF), the major pro-angiogenic protein. This trial will compare the effectiveness of interferon alfa-2b plus bevacizumab versus interferon alfa-2b alone in treating patients who have advanced renal cell carcinoma.
"This is the first phase III trial investigating a possible survival benefit from bevacizumab for kidney cancer," said Dr. Rini. "Because bevacizumab specifically blocks VEGF, a protein that is important in tumor angiogenesis and overexpressed as a result of the inherent biology of renal cell carcinoma, we believe that this type of therapy will be a major new therapeutic force in the treatment of the disease."
Who Can Join This Trial?
Where Is This Trial Taking Place?
Who to Contact