Drs. Weissman and Staudt Elected to Association of American Physicians
Dr. Weissman is an international leader in regulated membrane receptor turnover and ubiquitin-mediated protein degradation, including identification of RING finger proteins as ubiquitin ligases. He also played key roles in the characterization of T-cell antigen receptor (TCR) and cloned and characterized the TCR zeta chain - a key TCR signaling component.
Dr. Staudt cloned and characterized the lymphoid-restricted transcription factor Oct-2. In his laboratory, Dr. Staudt and colleagues study the molecular pathogenesis of human lymphoid malignancies. To provide a new molecular basis for the diagnosis of malignancies, his laboratory is exploiting DNA microarray technology to profile gene expression in these cancers on a genomic scale.
Von Hoff Discusses New Approaches to Treating Cancer
Dr. Von Hoff discussed his establishment of the community oncology model at the Arizona Comprehensive Cancer Center, which integrates local oncologists with cancer centers to enable them to participate in early phase clinical studies and helps "provide all of the patients in the community access to all therapies." His model has dramatically increased patient accrual to trials and successfully integrated the community physician into cutting-edge clinical science.
Dr. Von Hoff also described the transformational rise of microarrays to analyze tumors for upregulated gene products as the conventional approach in identifying pharmacological targets. He also noted that he sees critical targets in specific downregulated gene products as well - he referred to these as "nontargets." To help mine the valuable data provided by "nontargets," Dr. Von Hoff is developing a national database that will contain information from rapid-throughput screening to determine which known drugs are effective against tumors with downregulated genes.
Pat Newman Retires
Newman won numerous science writing awards for the many articles, news releases, background materials, and brochures she wrote or produced. She managed the preparation of such major reports as Horizons of Cancer Research, published under the sponsorship of the National Cancer Advisory Board, and served as liaison to the NIH, Department of Health and Human Services, and NCI-designated cancer centers. She spearheaded the press office's development of its online "NewsCenter" and an online magazine for the NCI Web site.
She also served, since 1999, as program advisor to the planning committee for the President's Cancer Panel. She developed communication strategies for the panel's regional meetings and performed literature research and analyses to guide their efforts in cancer patient survivorship and translational research.
NCI at Share the Health
NCI is pleased to participate in this event, which this year will include scientific poster sessions featuring the work of students from Takoma Park Middle School and Montgomery Blair High School. To encourage and stimulate these students' interest in science, NCI will have an exhibit at the expo and conduct presentations and mini-labs for young people.
This free event will be held from 10:00 a.m. to 3:30 p.m. on the 24th. Free shuttle service will be available from the Silver Spring Metro that day from 9:30 a.m. to 4:30 p.m. More information is available on the Share the Health Web site at http://sharethehealth.od.nih.gov/index.asp.