Chemoprevention Trial for Men at High Risk for Prostate Cancer
Name of the Trial
Phase III Randomized Study of Selenium as Chemoprevention of Prostate Cancer in Patients with High-Grade Prostatic Intraepithelial Neoplasia (SWOG-S9917). See the protocol summary at http://cancer.gov/clinicaltrials/SWOG-S9917.
Dr. Jim Marshall, Southwest Oncology Group; Dr. David Jarrard, Eastern Cooperative Oncology Group; and Dr. William Robert Lee, Cancer and Leukemia Group B.
Why Is This Trial Important?
Prostate cancer is an important source of morbidity and mortality among men in the industrialized world. High-grade prostatic intraepithelial neoplasia (HGPIN), a condition characterized by abnormal and uncontrolled growth of the ductal cells of the prostate, may be a precursor to prostate cancer.
Intake of the dietary supplement selenium is believed to protect against prostate cancer. Researchers are interested in determining whether a daily dose of selenium might prevent prostate cancer from developing among men with HGPIN.
"HGPIN is very likely a premalignant lesion for prostate cancer, so it is important to find a chemopreventive agent that will be effective for this high-risk group," said Dr. Marshall. "Selenium supplementation shows promise, so we need to know if it might prevent HGPIN from developing into prostate cancer."
Who Can Join This Trial?
Researchers seek to enroll 465 patients aged 40 or over with a diagnosis of HGPIN and no evidence of cancer. See the full list of eligibility criteria for this trial at http://cancer.gov/clinicaltrials/SWOG-S9917.
Where Is This Trial Taking Place?
Study sites in the United States and Puerto Rico are enrolling patients in this trial. See the list of sites at http://cancer.gov/clinicaltrials/SWOG-S9917.
Who to Contact
See the list of study contacts at http://cancer.gov/clinicaltrials/-S9917 or call the NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). The call is toll free and completely confidential.
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.