Chemoprevention of Recurrent Bladder Cancer
Name of the Trial
Why Is This Trial Important?
Celecoxib (Celebrex), a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID), has shown promise in animal studies for the prevention of many cancers (e.g., bladder, colorectal, esophageal, skin, breast, and prostate). It has also been proven to reduce colorectal polyps in patients with familial adenomatous polyposis, a condition that leads to the development of colorectal cancer. This trial will study the effectiveness of celecoxib in preventing the recurrence of superficial bladder cancer, which is characterized by high levels of the COX-2 enzyme.
"NSAIDs are arguably the most promising chemopreventive agents for epithelial cancers, such as bladder cancer," said Dr. Jaye Viner of the NCI Division of Cancer Prevention. "With this trial, we are exploring the possible benefits of celecoxib in bladder cancer patients who are at high risk for recurrence.
"Superficial bladder cancer often recurs, even after potentially curative surgery and standard follow-up treatment. There is a strong need to develop safe and effective interventions to reduce this risk," added Dr. Viner.
Who Can Join This Trial?
Where Is This Trial Taking Place?
Who to Contact
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.