Oblimersen Treatment for Older Patients with AML
Name of the Trial
Why Is This Trial Important?
In this trial, researchers are trying to determine whether adding the drug oblimersen (Genasense) to chemotherapy will improve survival in patients aged 60 and older who have previously untreated AML. Oblimersen blocks production of a protein called Bcl-2, which helps cancer cells survive. Bcl-2 is overexpressed in many types of tumors and contributes to cancer cell resistance to chemotherapy. By blocking production of Bcl-2, oblimersen may make cancer cells more susceptible to the cytotoxic effects of chemotherapy.
"Although AML long-term remission rates in younger patients are better, the long-term remission rates for AML in patients over 60 years old are very low, about 10-15 percent," said Dr. Marcucci. "AML is prevalent in the geriatric population in America, and as that population continues to grow, we can expect to see an increase in the number of older Americans with AML.
"That is why we need to come up with a new approach for treating AML in older patients," Dr. Marcucci added.
Who Can Join This Trial?
Where Is This Trial Taking Place?
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