Vaccine to Prevent Cervical Cancer
Name of the Trial
Why Is This Trial Important?
Some types of HPV are associated with cervical cancer more often than others; for example, HPV-Type 16 (HPV-16) is found in half of cervical cancers worldwide. However, the vast majority of women infected with HPV-16 will never develop cervical cancer and will clear their infections spontaneously because of immune responses to the virus. Nonetheless, developing therapeutic interventions for viral infections associated with low-grade cellular changes may allow us to block the effects of HPV long before a precancerous change or a malignancy develops.
In this study, researchers are testing a vaccine in women infected with HPV-16 who have LSIL or ASCUS Pap test results. The goal is to determine whether women who receive the study vaccine clear their infections and resolve their low-grade Pap test abnormalities more often than women who receive placebo (sterile water).
"Some women with HPV infections develop cancer because they don't seem to develop an appropriate immune response to the cancer-causing components of HPV," said Dr. Wiley. "We hope that this vaccine will help women develop that immune response."
Who Can Join This Trial?
Where Is This Trial Taking Place?
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.