Chemotherapy for Previously Treated CLL
Name of the Trial
Why Is This Trial Important?
In this clinical trial, researchers are testing the ability of a drug called flavopiridol to cause the remission of CLL that arises in a class of lymphocytes called B cells. In previous studies, flavopiridol was shown to stop the growth of CLL cells and cause apoptosis (cell "suicide"). Researchers hope that flavopiridol will help induce disease remission in patients whose CLL has recurred following previous treatment with other chemotherapy drugs.
"Flavopiridol kills CLL cells that are resistant to other therapies and that bear the genetic features that typically predict a poor response to treatment," said Dr. Byrd. "Unlike many new trials for relapsed and refractory CLL, where we are uncertain of the clinical activity, flavopiridol has already demonstrated dramatic and durable responses in some patients."
This trial will also test flavopiridol in patients with prolymphocytic leukemia (PLL), a more rapidly progressing type of CLL in which immature lymphocytes proliferate in the blood and bone marrow.
Who Can Join This Trial?
Where Is This Trial Taking Place?
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