Preoperative Radiotherapy for Retroperitoneal Sarcoma
Name of the Trial
Why Is This Trial Important?
Surgery is the primary treatment for patients with localized soft tissue sarcoma. Often, radiotherapy is used before or after surgery to improve the outcome of patients with soft tissue sarcoma of the head and neck or in an arm or leg. However, soft tissue sarcomas may also arise in the retroperitoneum, the narrow space between the abdominal cavity (which is lined by tissue called the peritoneum) and the posterior body wall. The retroperitoneum contains organs such as the kidneys, pancreas, and adrenal glands. The benefits of adding radiotherapy to surgery for retroperitoneal sarcoma are not clear.
In this trial, researchers are testing whether radiotherapy before surgery will help patients with retroperitoneal sarcoma survive longer without relapse of their cancer. Preoperative radiotherapy is thought to be more effective and less toxic than postoperative radiotherapy for this disease.
"Radiotherapy combined with surgery is the optimal treatment for most patients with sarcoma in an extremity, but we don't know yet if this combination is superior to surgery alone for retroperitoneal sarcoma," said Dr. Pisters. "This trial is designed to definitively answer that question."
Who Can Join This Trial?
Where Is This Trial Taking Place?
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