Allogeneic Stem Cell Transplantation for Metastatic Breast Cancer
Name of the Trial
Why Is This Trial Important?
Allogeneic stem cell transplantation (ASCT) has been used to cure patients with hematologic malignancies (blood and bone-marrow cancers) and may represent an effective alternative treatment for some types of solid tumors, including advanced breast cancers. In ASCT, peripheral blood stem cells and T lymphocytes from a sibling donor are infused into the patient's bloodstream after preparatory chemotherapy. The donor T lymphocytes may recognize the patient's cancer cells as foreign and attack them, leading to a potentially curative graft-versus-malignancy effect.
However, ASCT is accompanied by a significant risk of death and a range of serious complications, the most potentially deadly of which is graft-versus-host disease (GVHD). GVHD results when donor T lymphocytes attack a patient's normal tissues. It develops in the majority of transplant patients and represents a major barrier to the wider application of ASCT.
Recent refinements in ASCT have begun to reduce the incidence of GVHD, making the procedure a more attractive treatment option for patients with advanced solid tumors. In this study, researchers are investigating whether ASCT followed by the infusion of donor Th2/Tc2 cells - a type of T lymphocyte that is able to suppress GVHD - can be safely used to treat patients with metastatic breast cancer.
Who Can Join This Trial?
Where Is This Trial Taking Place?
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