Targeted Therapy for Imatinib-Resistant GI Cancer Approved
On January 26, the Food and Drug Administration (FDA) approved the experimental drug sunitinib (Sutent) for treating an uncommon gastrointestinal cancer in patients who are resistant to or unable to take the primary treatment, imatinib (Gleevec).
Many patients with this cancer, gastrointestinal stromal tumor (GIST), become resistant to imatinib within 2 years.
Sunitinib is a targeted therapy that inhibits multiple proteins involved in the growth of cancer cells and the formation of blood vessels that supply tumors with nutrients, a process called angiogenesis. Read more
Guest Update by Dr. John E. Niederhuber
NCI's Intramural Program: A Cornerstone for Success
To the public, NCI is often thought of in terms of being the largest supporter of cancer research in the world. That is clearly one of NCI's most important functions. Perhaps the untold story, however, is the outstanding research being carried out by the talented scientists and clinicians in the institute's intramural program, the foundation of which entails the Center for Cancer Research (CCR) and the Division of Cancer Epidemiology and Genetics (DCEG).
NCI's intramural researchers perform essential basic, clinical, and epidemiologic research, upon which a great deal of extramural research is eventually based. Much of this work is rooted in multidisciplinary, collaborative science that takes advantage of the breadth and depth of the National Institutes of Health (NIH) research environment. In many cases, the research conducted by the intramural program is both high risk and high impact, involving complex investigations that offer tremendous promise conducted in the most thoughtful, rigorous fashion to ensure meaningful results. The intramural program also serves as the training ground for thousands of investigators launching their careers in science. Read more