Chemotherapy for Recurrent Gliomas
Name of the Trial
Why This Trial Is Important
In this clinical trial, researchers are testing a new drug called enzastaurin in patients whose glioma has recurred after previous radiotherapy and chemotherapy. Enzastaurin is an angiogenesis inhibitor, meaning it prevents tumors from developing the new blood vessels they need for growth. In addition, enzastaurin has been shown to have direct effects on tumor cells, inhibiting their proliferation and stimulating apoptosis (cell death). Researchers hope to determine how much enzastaurin patients can receive before developing side effects severe enough to interrupt treatment.
"In a previous trial of enzastaurin for high-grade, recurrent gliomas, we observed very dramatic tumor responses, including some complete responses," Dr. Fine said. "In addition, the drug has been very well tolerated by patients.
"Our research indicates that enzastaurin becomes more toxic to gliomas cells with higher dose, so we are conducting this trial to see how much enzastaurin patients can tolerate. We hope to set a dose that will maximize the cytotoxic potential of enzastaurin while maintaining a favorable toxicity profile in preparation for a large, multinational phase III clinical trial."
Who Can Join This Trial
Study Site and Contact Information
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