Targeted Therapy for Liver or Biliary Tract Cancer
Name of the Trial
Why This Trial Is Important
In this clinical trial, researchers are testing the ability of a new drug called lapatinib to delay tumor growth and possibly improve the survival of patients with inoperable hepatocellular or biliary tract cancer. Lapatinib works by disrupting chemical signals that stimulate the growth and spread of cancer cells. Specifically, this drug blocks the activity of two tyrosine kinases (proteins involved in cell communication) called EGFR and HER2, which are found in increased amounts on some types of cancer cells, including hepatocellular and biliary tract cancers.
"Lapatinib represents a new generation of targeted therapies in that it targets multiple proteins that affect the growth and metastatic potential of cancer cells," said Dr. Bekaii-Saab. "The EGFR and HER2 proteins may work in tandem in these tumors, so it makes sense to employ an agent that can effectively block the activity of both proteins.
"Patients with inoperable liver or biliary tract cancer have very few options available to them," Dr. Bekaii-Saab said. "We hope that lapatinib will offer these patients a new and more effective treatment choice than traditional chemotherapy."
Who Can Join This Trial
Study Site and Contact Information
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