NCI Cancer Bulletin: A Trusted Source for Cancer Research NewsNCI Cancer Bulletin: A Trusted Source for Cancer Research News
March 14, 2006 • Volume 3 / Number 11 E-Mail This Document  |  Download PDF  |  Bulletin Archive/Search  |  Subscribe

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Featured Article

Researchers Discover a Unique Molecular Profile for
Lung Cancer

A team of researchers has found that the expression pattern of certain microRNAs (miRNAs) may predict tumor aggressiveness in some patients with lung cancer. These findings indicate that miRNAs may represent a new class of diagnostic and prognostic tools for lung cancer, according to study results in the March 13 Cancer Cell.

miRNAs are small segments of RNA thought to control gene expression. Their actions could change the expression of cancer-related genes within a cell and lead to malignancies.

The researchers identified two miRNAs - has-mir-155 and has-let-7a-2 - that could be used as prognostic indicators in patients with adenocarcinoma of the lung. High levels of has-mir-155 or low levels of has-let-7a-2 were associated with poor prognosis. Specifically, overexpression of has-mir-155 was the most significant indicator of this prognosis, independent of tumor stage. Although these miRNAs have been identified in other cancers, this is the first evidence linking has-mir-155 to lung cancer.  Read more  

Director's Update

Guest Update by Dr. Robert Croyle

NCI's Tobacco Control Research Yields Results

This is an exciting time in tobacco control research, particularly because of the excellent progress that has been made in smoking prevention and cessation.

Cigarette sales, for example, are at their lowest point in more than 5 decades. Our messages about the dangers of smoking and secondhand smoke exposure are being heard: more and more U.S. cities and states, not to mention many other countries, have passed laws that ban smoking in public establishments, including workplaces, restaurants, and bars.  Read more  


The NCI Cancer Bulletin is produced by the National Cancer Institute (NCI). NCI, which was established in 1937, leads the national effort to eliminate the suffering and death due to cancer. Through basic, clinical, and population-based biomedical research and training, NCI conducts and supports research that will lead to a future in which we can identify the environmental and genetic causes of cancer, prevent cancer before it starts, identify cancers that do develop at the earliest stage, eliminate cancers through innovative treatment interventions, and biologically control those cancers that we cannot eliminate so they become manageable, chronic diseases.

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