Treatment for Malignant Ascites
Name of the Trial
Why This Trial Is Important
Paracentesis, the use of a thin needle or tube to remove excess fluid from the abdomen, can provide temporary relief from ascites. However, this and most other methods for treating ascites are invasive and uncomfortable for patients.
Octreotide, a drug similar to a naturally occurring growth-hormone inhibitor called somatostatin, decreases the secretion of fluid by the intestines and increases water reabsorption. Laboratory studies and case reports have indicated that octreotide may be effective in controlling malignant ascites, but the drug has not been tested in a randomized trial.
This trial will randomly assign patients with malignant ascites to receive a shot of either octreotide or a placebo once a month for up to 2 years. The investigators will see whether octreotide can delay the time until paracentesis is necessary or even whether the need for the paracentesis can be eliminated. They will also compare side effects and quality of life between the two groups.
"Ascites is a terrible problem for patients, and we often have to resort to invasive procedures to help them," explained Dr. Jatoi. "If there were some way we could help patients with this problem and not put them through invasive procedures every couple of weeks, that would be a really good thing."
Who Can Join This Trial
Study Sites and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.