Interleukins Power Immune Reaction to Metastatic Cancer
New results from NCI's Center for Cancer Research (CCR), reported in the November 15 Cancer Research, show promise for interleukins (IL) to enhance the body's natural ability to fight cancer that has spread to the liver. A combination of IL-12 and IL-18 increased the concentration of natural killer (NK) cells in animals and triggered therapeutic levels of interferon-gamma (IFN-γ), a key messenger molecule that regulates the immune system defenses against cancer in the liver, a common site of tumor metastasis.
Guest Update by Dr. Malcolm Smith
Initiative TARGETs Childhood Cancer
Although there has been an explosion in the development of molecularly targeted therapies, these advances have been largely limited to the treatment of adult cancers. The need for new treatment approaches for childhood cancers, however, is substantial. The dramatic improvements in outcome seen over the last several decades have slowed, and, in many cases, current treatment approaches for childhood cancers cause serious short- and long-term side effects.
To see that children do benefit from advances in molecularly targeted cancer therapeutics development, NCI and the Foundation for the National Institutes of Health (FNIH) have established the Childhood Cancer Therapeutically Applicable Research to Generate Effective Treatments, or TARGET, Initiative.
The TARGET Initiative is a public-private partnership to identify and validate therapeutic targets so that new, more effective treatments can be developed for children with cancer. Its immediate goal is to make major advances in identifying and validating therapeutic targets for two or more childhood cancers within 2 years of project initiation. FNIH will raise money from the private sector to augment NCI resources allotted for the initiative. Read more