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About CCCT

Overview

The Coordinating Center for Clinical Trials (CCCT) was established in 2006 and resides within the NCI's Office of the Director. Its overarching goal is to strengthen NCI's clinical trials and translational research enterprises – cooperative endeavors that draw upon the strongest components of its clinical research system, the Institute's scientific infrastructure and constant engagement of critical stakeholders.

CCCT guided the implementation of recommendations made by the National Cancer Advisory Board's (NCAB)'s Clinical Trials Working Group (CTWG) and Translational Research Working Group (TRWG). It currently facilitates dialogue among NCI and the extramural clinical trials and translational research communities through the Clinical Trials and Translational Research Advisory Committee (CTAC) , Scientific Steering Committees and other related initiatives. This is achieved through continuing dialogue with NCI leadership and scientific staff, clinicians, researchers, advocates, policymakers, industry and foundations, in order to enhance the effectiveness of our nation's cancer clinical research enterprise.

CCCT is central to NCI's efforts to accelerate the delivery of new tools into the clinic through its translational science and clinical trial enterprises. In conjunction with all NCI divisions, offices, and centers, CCCT facilitates collaborations that expedite translational and clinical cancer research by:

  • Facilitating the review and prioritization of the NCI's most important clinical trials by Scientific Steering Committees;
  • Establishing the Clinical Trials Reporting Program (CTRP), a comprehensive database with up-to-date information on all NCI-funded clinical trials;
  • Managing CTROC and CTAC, which advise NCI leadership on clinical and translational science and clinical trials; and
  • Facilitating an ongoing dialogue between the Institute's various divisions, offices, and centers, represented by CTROC, and the extramural clinical and translational research communities, represented by CTAC.
CCCT org graphic

CCCT facilitates an ongoing dialogue between the Institute's various divisions, offices, and centers, represented by CTROC, and the extramural clinical and translational research communities, represented by CTAC. View PDF of graphic (280 kb)

Clinical and Translational Research Operations Committee (CTROC)

CTROC is an internal NCI advisory committee composed of representatives from NCI divisions, offices, and centers involved in NCI-supported clinical trials and translational research. The committee reviews and prioritizes NCI-supported clinical trials and translational research. CCCT staff coordinate CTROC operations.

Clinical Trials Working Group (CTWG)

CTWG Evaluation Working Group

The following reports describe strategies to implement CTWG recommendations:

Guidelines Harmonization Working Group (GHWG)

Translational Research Working Group (TRWG)

The following reports describe strategies to implement TRWG recommendations:

Immune Response Modifier Pathway Prioritization Working Group (IRMP WG)

Process to Accelerate Translational Science (PATS) Working Group

NCI Process to Accelerate Translational Science (PATS) Working Group Report, Final Report, September 2010