Final Report TRWG Report - June 2007 1 Executive Summary 2 Full TRWG Report 3 Related Meetings NCI Translational Science Meeting 4 Related Pages TRWG Home 5 TRWG Definition of Translational Research 6 TRWG Leadership 7 TRWG Membership 8 Introduction to the TRWG Developmental Pathways 9 Process Analysis Summary 10 TRWG Portfolio Analysis Summary 11 Roundtable Information 12 Related Foundational Documents 13 Presentations 14 Communication and Outreach 15

Background
The TRWG members are considering previous and concurrent efforts that examined translational research in cancer and their proposed specific recommendations. Brief summaries and document links are listed below.

P30/P50 Report
"Advancing Translational Cancer Research: A Vision of the Cancer Center and SPORE Programs of the Future ¹⁶"
P30 refers to the NCI's Cancer Center support Grant (CCSG) program, and the P50 to the Specialized Programs of Research Excellence (SPORE) awards. The National Cancer Advisory Board (NCAB ¹⁷) convened an ad hoc committee to look at translational research in both of these programs, and received a 44-page report with recommendations.

President's Cancer Panel Report
"Translating Research into Cancer Care: Delivering on the Promise ¹⁸"
The President's Cancer Panel report to the President for 2004-05 is focused on the translation of basic science discoveries into improved cancer prevention and care. The recommendations address a spectrum of activities extending through knowledge dissemination and access to care.

NIH Roadmap
The National Institutes of Health (NIH ¹⁹), of which NCI is the largest single institute, under Director Elias A. Zerhouni, has developed a "Roadmap" for medical research in the 21st century. Translational research is one of five related initiatives established to "Re-Engineer the Clinical Research Enterprise ²⁰."

Relevant Progress Review Group Reports
Progress Review Groups ²¹ (PRGs) develop recommendations for cancer-specific investments. Several PRG reports address the role of translational research in---

• Leukemia, Lymphoma, and Myeloma ²² (May 2001)
• Lung cancer ²³ (August 2001)
• Cancer of the kidney and bladder ²⁴ (July 2002)
• Cancer of the stomach and esophagus ²⁵ (December 2002)
• Sarcoma ²⁶ (January 2004)

Cancer at a Crossroads
"Cancer at a Crossroads: A Report to Congress for the Nation" ²⁷
The National Cancer Advisory Board (NCAB) periodically reports to the U.S. Congress on the status of the National Cancer Program. In September 1994, the NCAB released this report that addressed all stages of the National Cancer Program, from basic research to delivery of cancer care.

Clinical Trials Working Group Report
"Restructuring the National Cancer Clinical Trials Enterprise" ²⁸
In June 2005, the Clinical Trials Working Group was established by NCI to advise the National Cancer Advisory Board on issues concerning NCI-supported cancer clinical trials.

Critical Path Initiative
"Challenge and Opportunity on the Critical Path to New Medical Products" ²⁹
This report provided the FDA with an analysis of the pipeline problem in innovative medical therapies reaching patients.