Funding Opportunities - Active Program Announcements

Notices:

02/05/2004 -NCI's co-sponsorship of PAR 03-153 for clinical exploratory/developmental projects in CAM

Call for Supplements:

NCI Supplements Available: NOT-CA-05-016 (cancer letter 31(12) p.7

Program Announcements:

The Bernard Osher Foundation/NCCAM CAM Practitioner Research Career Development Award (K01)
PAR-07-003
Release Date: 10/5/2006
Expiration Date: 1/3/2010
The specific purpose of this research career development Award (K01) is to provide research training support for CAM Practitioners with clinical doctorates, who have had limited opportunities for research training, but a strong desire to pursue a career in CAM research. The long term goal is to encourage more CAM practitioners to enter research careers, thus enriching CAM research through their experience and knowledge of CAM practice. This award will provide support and “protected” time (three, four, or five years) for intensive, supervised career development research experience in the biomedical, behavioral, or clinical sciences related to CAM.

Basic and Preclinical Research on Complementary and Alternative Medicine (R21)
PA-06-315
Release Date: 11/20/2006
Expiration Date: 9/2/2008
This announcement encourages CAM and conventional researchers to carry out basic and/or preclinical research on CAM areas of special interest with an aim to understand the mechanisms of action of a CAM modality. NCI solicits applications on basic, mechanistic, and preclinical research as it relates to the prevention, diagnosis, and treatment of cancer as well as management of cancer symptoms and side effects due to conventional cancer treatment. Areas of interest include interactions between conventional cancer treatment and CAM modalities

Basic and Preclinical Research on Complementary and Alternative Medicine (R01)
PA-07-007
Release Date: 11/20/2006
Expiration Date: 9/2/2008
This announcement encourages complementary and alternative medicine (CAM) and conventional researchers to carry out basic and/or preclinical research on CAM areas of special interest with an aim to understand the mechanisms of action of a CAM modality. NCI solicits applications on basic, mechanistic, and preclinical research as it relates to the prevention, diagnosis, and treatment of cancer as well as management of cancer symptoms and side effects due to conventional cancer treatment. Areas of interest include interactions between conventional cancer treatment and CAM modalities.

Diet, Epigenetic Events, and Cancer Prevention (R01)
PA-07-175
Release Date: 12/15/2006
Expiration Date: 9/2/2009
The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. This FOA will use the NIH research project grant (R01) award mechanism.

Pathogenesis and Treatment of Lymphedema and Lymphatic Diseases (R01)
PA-07-165
Release Date: 12/14/06
Expiration Date: 12/31/09
The purpose of this program announcement is to stimulate research on the biology of the lymphatic system, to characterize at the molecular, cellular, tissue, organ, and intact organism levels, the pathophysiologic mechanisms that cause the disease, to develop new methods for quantitating and imaging lymph flow, to discover new therapeutic interventions, and to determine the safety, efficacy and mechanisms of action of complementary and alternative therapies.

Prioritizing Molecular Targets for Cancer Prevention with Nutritional Combinations
PA-07-100
Release Date: 12/1/2006
Expiration Date: 11/2/2009
This announcement solicits innovative research project (R01) grant applications to enhance mechanistic understanding of the dynamic interrelationship between bioactive food components and/or food combinations and cancer prevention. Projects must focus on either multiple dietary bioactive components, intact foods, and/or multiple foods utilizing physiologically relevant concentrations of the bioactive agents.

Mechanisms, Models, Measurement, & Management in Pain Research (R21)
PA-06-542
Release Date: 8/30/2006
Expiration Date: 9/2/2009
This announcement utilizes the R21 grant mechanism. New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences. The purpose of this funding announcement is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs.

Mechanisms, Models, Measurement, & Management in Pain Research (R03)
PA-06-543
Release Date: 8/30/2006
Expiration Date: 9/2/2009
This announcement utilizes the R03 grant mechanism. New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences. The purpose of this funding announcement is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs.

Mechanisms, Models, Measurement, & Management in Pain Research (R01)
PA-06-544
Release Date: 8/30/2006
Expiration Date: 9/2/2009
This announcement utilizes the R01 grant mechanism. New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences. The purpose of this funding announcement is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs.

NCCAM-Exploratory /Developmental Grant for Clinical Studies of Complementary and Alternative Medicine
PA-06-510
Release Date: 8/4/2006
Expiration Date: 9/2/2008
The National Center for Complementary and Alternative Medicine (NCCAM) and the National Cancer Institute (NCI) share the interest in research applications that focus on complementary and alternative medical approaches related to the prevention, diagnosis, and treatment of cancer. High quality exploratory/developmental clinical research grant applications that focus on CAM approaches related to cancer symptoms and side-effects of cancer treatment as well as survivorship are invited. Applications related to bioactive food components in the domain of translational nutritional sciences should identify molecular targeting efficiencies of a single or a combination of nutrients and/or bioactive foods component(s) which could protect against the development of cancer. It is anticipated that these pilot R21 studies will generate supporting preliminary clinical data that can be used to support larger clinical studies.

Diet, Epigenetic Events, and Cancer Prevention (R21)
PA-06-413
Release Date: 5/16/2006
Expiration Date: 9/2/2009
The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. This FOA utilizes the NIH exploratory/developmental (R21) grant mechanism.

Diet, Epigenetic Events, and Cancer Prevention (R03)
PA-06-414
Release Date: 5/16/2006
Expiration Date: 9/2/2009
The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. This FOA will use the NIH research project grant (R03) award mechanism.

Studies of Energy Balance and Cancer in Humans (R01)
PA-06-404
Release Date: 5/9/2006
Expiration Date: 5/9/2009
The National Cancer Institute (NCI) invites investigator-initiated research applications on energy balance in humans. These studies will focus on research to define factors affecting energy balance and to define mechanisms influencing cancer risk, prognosis, and quality of life. These studies may range from new analyses of existing datasets to additional collection of data and biological specimens in ongoing investigations. It is anticipated that the knowledge gained will provide additional information to better understand the relationships among energy balance, cancer risk, and cancer prognosis. Competitive supplement applications to existing NCI-funded grants as well as new R01 applications are invited.

Studies of Energy Balance and Cancer in Humans (R21)
PA-06-405
Release Date: 5/9/2006
Expiration Date: 5/9/2009
The National Cancer Institute (NCI) invites investigator-initiated research applications on energy balance in humans. These studies will focus on research to define factors affecting energy balance and to define mechanisms influencing cancer risk, prognosis, and quality of life. These studies may range from new analyses of existing datasets to additional collection of data and biological specimens in ongoing investigations. It is anticipated that the knowledge gained will provide additional information to better understand the relationships among energy balance, cancer risk, and cancer prognosis. Competitive supplement applications to existing NCI-funded grants as well as new R01 applications are invited. This FOA utilizes the NIH exploratory/developmental (R21) grant mechanism.

Exploratory Grants for Behavioral Research in Cancer Control (R21)
PA-06-351
Release Date: 04/12/2006
Expiration Date: 05/02/2009
NCI invites the submission of behavioral research applications in cancer control from investigators from a wide range of behavioral and social science disciplines who wish to focus their research on the behavioral aspects of the cancer control continuum from prevention to end of life care.

Diet-Induced Changes in Inflammation as Determinants of Colon Cancer (R01)
PA-07-186
Release Date: 12/18/06
Expiration Date: 9/2/2008
The goal of this R01 concept is to foster innovative research that will identify and characterize diet-induced changes in inflammation and colon cancer risk. This FOA does not encompass epidemiological studies. The purpose of this initiative is to promote research to: (1) Identify and characterize diet-induced changes in anti- and proinflammatory mediators that modulate colon cancer risk; (2) define genetic polymorphisms that modify the response to specific bioactive food components with regard to colon cancer inhibition; and (3) unravel the physiological effectiveness of dietary components in terms of concentration, activity, duration of exposure, degree of stability, chemical forms, and binding affinity to receptors in inflammatory colonocytes.

Diet-Induced Changes in Inflammation as Determinants of Colon Cancer (R21)
PA-06-283
Release Date: 3/28/06
Expiration Date: 7/2/2008
The goal of this R21 concept is to foster innovative research that will identify and characterize diet-induced changes in inflammation and colon cancer risk. This FOA does not encompass epidemiological studies. The purpose of this initiative is to promote research to: (1) Identify and characterize diet-induced changes in anti- and proinflammatory mediators that modulate colon cancer risk; (2) define genetic polymorphisms that modify the response to specific bioactive food components with regard to colon cancer inhibition; and (3) unravel the physiological effectiveness of dietary components in terms of concentration, activity, duration of exposure, degree of stability, chemical forms, and binding affinity to receptors in inflammatory colonocytes.

Quick-Trials for Novel Cancer Therapies: Exploratory Grants (R21)
PAR-06-451
Release Date: June 9, 2006
Expiration Date: December 10, 2007
Advances in the understanding of molecular cancer genetics, basic cancer biology, and the development of powerful technologies, such as microarray, proteomics, and bioinformatics, have led to the identification of many new molecular targets and pathways in cancer cells. These discoveries have created new frontiers for novel molecular cancer prevention and treatment leading to the development of molecular medicine in cancer therapy. In addition, these novel targets and pathways have presented excellent translational research opportunities for revolutionizing cancer drug development and bringing more effective molecular cancer therapies and cancer prevention strategies into clinical practice. This R21 will continue to support scientific, technological, clinical, and logistical needs in novel cancer therapy development.

Social and Cultural Dimensions of Health
PA-07-045
Release Date: 11/21/06
Expiration Date: 1/03/08
The purpose of this announcement is to integrate research in the biomedical and social sciences and to encourage further development of health-related social sciences research. The goals of this announcement include the following: to elucidate basic and social and cultural constructs and processes used in health research; to clarify social and cultural factors in the etiology and consequences of health and illness; to link basic research to practice for improving prevention, treatment, health services, and dissemination; and to explore ethical issues in social and cultural research related to health.

Methodology and Measurement in the Behavioral and Social Sciences (R01)
PA-07-060
Release Date: 11/20/06
Expiration Date: 5/02/08
This initiative encourages applications addressing four general areas of methodology and measurement research in the social and behavioral sciences. The areas are research design, data collection techniques, measurement, and data analysis.

Methodology and Measurement in the Behavioral and Social Sciences (R03)
PA-06-344
Release Date: 4/14/06
Expiration Date: 5/02/08
This initiative encourages applications addressing four general areas of methodology and measurement research in the social and behavioral sciences. The areas are research design, data collection techniques, measurement, and data analysis.

Methodology and Measurement in the Behavioral and Social Sciences (R21)
PA-06-343
Release Date: 4/14/06
Expiration Date: 5/02/08
This initiative encourages applications addressing four general areas of methodology and measurement research in the social and behavioral sciences. The areas are research design, data collection techniques, measurement, and data analysis.

Developmental Projects in Complementary Approaches to Cancer Care
PA-06-400
Release Date: 05/09/06
Expiration Date: 02/02/09, unless reissued
NIH invites research grant applications from interested investigators to conduct innovative developmental pilot research investigating complementary approaches in cancer. The intent of this initiative is to encourage and support the development of basic and clinical complementary cancer research and to provide the basis for more extended research projects.

Clinical Cancer Therapy and Prevention Research (R01)
PA-07-356
Release Date: 04/16/07
Expiration Date: 05/08/10
The NCI is seeking R01 applications to conduct translational, clinical, therapeutic, and preventive studies/trials of neoplastic diseases in humans and encourages clinical researchers to collaborate with basic scientists to translate insights in cancer biology and the development of new anti-cancer agents into innovative cancer intervention studies/trials. The overall aims of this funding opportunity announcement are two-fold: (1) to stimulate the development of innovative cancer prevention and therapy clinical trials with or without laboratory correlative studies; and (2) to support innovative correlative laboratory studies retrospectively and prospectively linked to therapeutic/preventive clinical trials.