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Cancer Drug Information

  • Posted: 05/21/2008
  • Updated: 10/26/2011

Methotrexate

listen 1  (meh-thuh-TREK-sayt)

This page contains brief information about methotrexate and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.

US Brand Name(s): Abitrexate
Folex PFS
Folex
Methotrexate LPF
Mexate-AQ
Mexate
FDA Approved: Yes

Use in Cancer

Methotrexate is approved to be used alone or with other drugs to treat:

Methotrexate is also being studied in the treatment of other types of cancer.

More About Methotrexate

Definition from the NCI Drug Dictionary 2 - Detailed scientific definition and other names for this drug.

MedlinePlus Information on Methotrexate 3 - A lay language summary of important information about this drug that may include the following:

  • warnings about this drug,
  • what this drug is used for and how it is used,
  • what you should tell your doctor before using this drug,
  • what you should know about this drug before using it,
  • other drugs that may interact with this drug, and
  • possible side effects.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Research Results

Clinical Trial Results: Young Children with Medulloblastoma May Be Able to Avoid Post-Surgery Radiotherapy 4 - Important clinical trial results for this drug, background information, and how the trial was done.

Children Often Develop Fragile Bones from Cancer and Its Treatment 5 - Information about the use of this drug to treat cancer.

During Pregnancy, Chemotherapy for Breast Cancer Is Safe 6 - Information about the use of this drug to treat cancer.

Immunosuppressant Drug Methotrexate May Increase Risk of Lymphoma 7 - Information about the use of this drug to treat cancer.

Clinical Trials Accepting Patients

Find Clinical Trials for Methotrexate 8 - Check for trials from NCI's list of cancer clinical trials now accepting patients.

Important: The drug information on this page is meant to be educational. It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.


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Glossary Terms

acute lymphoblastic leukemia (uh-KYOOT LIM-foh-BLAS-tik loo-KEE-mee-uh)
An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called acute lymphocytic leukemia and ALL.
advanced cancer (ad-VANST KAN-ser)
Cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment.
breast cancer (brest KAN-ser)
Cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare.
cancer (KAN-ser)
A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
central nervous system (SEN-trul NER-vus SIS-tem)
The brain and spinal cord. Also called CNS.
cutaneous T-cell lymphoma (kyoo-TAY-nee-us … lim-FOH-muh)
Any of a group of T-cell non-Hodgkin lymphomas that begins in the skin as an itchy, red rash that can thicken or form a tumor. The most common types are mycosis fungoides and Sézary syndrome.
drug (drug)
Any substance, other than food, that is used to prevent, diagnose, treat or relieve symptoms of a disease or abnormal condition. Also refers to a substance that alters mood or body function, or that can be habit-forming or addictive, especially a narcotic.
gestational trophoblastic tumor (jeh-STAY-shuh-nul troh-fuh-BLAS-tik TOO-mer)
Any of a group of tumors that develops from trophoblastic cells (cells that help an embryo attach to the uterus and help form the placenta) after fertilization of an egg by a sperm. The two main types of gestational trophoblastic tumors are hydatidiform mole and choriocarcinoma. Also called gestational trophoblastic disease.
head and neck cancer (... KAN-ser)
Cancer that arises in the head or neck region (in the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx [voice box]).
lung cancer (lung KAN-ser)
Cancer that forms in tissues of the lung, usually in the cells lining air passages. The two main types are small cell lung cancer and non-small cell lung cancer. These types are diagnosed based on how the cells look under a microscope.
mycosis fungoides (my-KOH-sis fun-GOY-deez)
A type of non-Hodgkin lymphoma that first appears on the skin and can spread to the lymph nodes or other organs such as the spleen, liver, or lungs.
non-Hodgkin lymphoma (non-HOJ-kin lim-FOH-muh)
Any of a large group of cancers of lymphocytes (white blood cells). Non-Hodgkin lymphomas can occur at any age and are often marked by lymph nodes that are larger than normal, fever, and weight loss. There are many different types of non-Hodgkin lymphoma. These types can be divided into aggressive (fast-growing) and indolent (slow-growing) types, and they can be formed from either B-cells or T-cells. B-cell non-Hodgkin lymphomas include Burkitt lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell non-Hodgkin lymphomas include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas that occur after bone marrow or stem cell transplantation are usually B-cell non-Hodgkin lymphomas. Prognosis and treatment depend on the stage and type of disease. Also called NHL.
osteosarcoma (OS-tee-oh-sar-KOH-muh)
A cancer of the bone that usually affects the large bones of the arm or leg. It occurs most commonly in young people and affects more males than females. Also called osteogenic sarcoma.
prevention (pree-VEN-shun)
In medicine, action taken to decrease the chance of getting a disease or condition. For example, cancer prevention includes avoiding risk factors (such as smoking, obesity, lack of exercise, and radiation exposure) and increasing protective factors (such as getting regular physical activity, staying at a healthy weight, and having a healthy diet).
primary tumor (PRY-mayr-ee TOO-mer)
The original tumor.
surgery (SER-juh-ree)
A procedure to remove or repair a part of the body or to find out whether disease is present. An operation.

Table of Links

1http://www.cancer.gov/PublishedContent/Media/CDR/Media/705408.mp3
2http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=41719
3http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682019.html
4http://www.cancer.gov/clinicaltrials/results/childhood-medulloblastoma0305
5http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_030607/page5
6http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_070505/page5#d
7http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_112304/page5
8http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41719&idtype=1
9http://www.cancer.gov/cancertopics/druginfo/alphalist
10http://www.cancer.gov/cancertopics/druginfo/drug-page-index
11http://www.cancer.gov/clinicaltrials/learningabout/approval-process-for-cancer-
drugs
12http://www.cancer.gov/cancertopics/factsheet/Therapy/investigational-drug-access