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Cancer Drug Information

  • Posted: 02/01/2008
  • Updated: 08/12/2011

Nilotinib

listen 1  (ny-LOH-tih-nib)

This page contains brief information about nilotinib and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.

US Brand Name(s): Tasigna
FDA Approved: Yes

FDA Approval for Nilotinib 2

Use in Cancer

Nilotinib is approved to treat:

Nilotinib is also being studied in the treatment of other types of cancer.

More About Nilotinib

Definition from the NCI Drug Dictionary 3 - Detailed scientific definition and other names for this drug.

MedlinePlus Information on Nilotinib 4 - A lay language summary of important information about this drug that may include the following:

  • warnings about this drug,
  • what this drug is used for and how it is used,
  • what you should tell your doctor before using this drug,
  • what you should know about this drug before using it,
  • other drugs that may interact with this drug, and
  • possible side effects.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Targeted Cancer Therapies 5 - Information about the use of this drug to treat cancer.

Research Results

Clinical Trial Results: Trials Point to More Treatment Options for Chronic Myeloid Leukemia 6 - Important clinical trial results for this drug, background information, and how the trial was done.

Clinical Trial Results: Dasatinib and Nilotinib Both Effective for Chronic Myelogenous Leukemia When Imatinib Won't Work 7 - Important clinical trial results for this drug, background information, and how the trial was done.

Clinical Trials Accepting Patients

Find Clinical Trials for Nilotinib 8 - Check for trials from NCI's list of cancer clinical trials now accepting patients.

Important: The drug information on this page is meant to be educational. It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.


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Glossary Terms

cancer (KAN-ser)
A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
chronic myelogenous leukemia (KRAH-nik MY-eh-LAH-jeh-nus loo-KEE-mee-uh)
A slowly progressing disease in which too many white blood cells (not lymphocytes) are made in the bone marrow. Also called chronic granulocytic leukemia, chronic myeloid leukemia, and CML.
Philadelphia chromosome (FIH-luh-DEL-fee-uh KROH-muh-some)
An abnormality of chromosome 22 in which part of chromosome 9 is transferred to it. Bone marrow cells that contain the Philadelphia chromosome are often found in chronic myelogenous leukemia.
positive test result (PAH-zih-tiv ... reh-ZULT)
A test result that reveals the presence of a specific disease or condition for which the test is being done.

Table of Links

1http://www.cancer.gov/PublishedContent/Media/CDR/Media/721206.mp3
2http://www.cancer.gov/cancertopics/druginfo/fda-nilotinib
3http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=435988
4http://www.nlm.nih.gov/medlineplus/druginfo/meds/a608002.html
5http://www.cancer.gov/cancertopics/factsheet/Therapy/targeted
6http://www.cancer.gov/clinicaltrials/results/dasitinib-nilotinib-cml0710
7http://www.cancer.gov/clinicaltrials/results/dastinib-nilotinib-CML1007
8http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=435988&idtype=1
9http://www.cancer.gov/cancertopics/druginfo/alphalist
10http://www.cancer.gov/cancertopics/druginfo/drug-page-index
11http://www.cancer.gov/clinicaltrials/learningabout/approval-process-for-cancer-
drugs
12http://www.cancer.gov/cancertopics/factsheet/Therapy/investigational-drug-access