Related pages Drug Information Summaries 1 Approval Process for New Cancer Treatments 2 Access to Investigational Drugs 3

This page contains brief information about sorafenib tosylate and a collection of links to more information about the use of this drug, related research results, and ongoing clinical trials.

US Brand Name(s):		Nexavar
FDA Approved:		Yes

Sorafenib tosylate is approved by the Food and Drug Administration (FDA) to treat advanced renal cell carcinoma (a type of kidney cancer) in adults. It is also approved to treat a type of liver cancer called hepatocellular carcinoma (HCC) when it cannot be removed by surgery.

Sorafenib tosylate is also being studied in the treatment of other types of cancer.

FDA Approval for Sorafenib Tosylate ⁴ - Information from the FDA about the approval of this drug and the clinical trials that led to the approval.

Definition from the NCI Drug Dictionary ⁵ - Detailed scientific definition and other names for this drug.

Clinical Trial Results: Sorafenib Increases the Risk of High Blood Pressure (04/02/2008) ⁶ - Important clinical trial results for this drug, background information, and how the trial was done.

Clinical Trial Results: Sorafenib for Advanced Liver Cancer Increases Survival (06/13/2007) ⁷ - Important clinical trial results for this drug, background information, and how the trial was done.

Clinical Trial Results: Sorafenib Delays Progression of Metastatic Kidney Cancer (02/07/2007) ⁸ - Important clinical trial results for this drug, background information, and how the trial was done.

MedlinePlus Information on Sorafenib Tosylate ⁹ - A lay language summary of important information about this drug that may include the following:

• warnings about this drug,
• what this drug is used for and how it is used,
• what you should tell your doctor before using this drug,
• what you should know about this drug before using it,
• other drugs that may interact with this drug, and
• possible side effects.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This NLM patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Clinical Trials for Sorafenib Tosylate ¹⁰ - Check for trials from NCI's PDQ Cancer Clinical Trials Registry now accepting patients.

Glossary Terms

Cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment.

A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.

An agency in the U.S. federal government whose mission is to protect public health by making sure that food, cosmetics, and nutritional supplements are safe to use and truthfully labeled. The Food and Drug Administration also makes sure that drugs, medical devices, and equipment are safe and effective, and that blood for transfusions and transplant tissue are safe. Also called FDA.

A type of adenocarcinoma, the most common type of liver tumor.

The most common type of kidney cancer. It begins in the lining of the renal tubules in the kidney. The renal tubules filter the blood and produce urine. Also called hypernephroma.

A procedure to remove or repair a part of the body or to find out whether disease is present. An operation.