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Cancer Drug Information

  • Posted: 02/28/2008
  • Updated: 11/07/2011

Tositumomab and Iodine I 131 Tositumomab

listen 1  (TAH-sih-TOO-moh-mab ... I-oh-dine I 131 TAH-sih-TOO-moh-mab)

This page contains brief information about tositumomab and iodine I 131 tositumomab and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.

US Brand Name(s): Bexxar
FDA Approved: Yes

FDA Approval for Tositumomab and Iodine I 131 Tositumomab 2

Use in Cancer

Tositumomab and iodine I 131 tositumomab is approved to treat:

Tositumomab and iodine I 131 tositumomab is also being studied in the treatment of other types of cancer.

More About Tositumomab and Iodine I 131 Tositumomab

Definition from the NCI Drug Dictionary 3 - Detailed scientific definition and other names for this drug.

MedlinePlus Information on Tositumomab and Iodine I 131 Tositumomab 4 - A lay language summary of important information about this drug that may include the following:

  • warnings about this drug,
  • what this drug is used for and how it is used,
  • what you should tell your doctor before using this drug,
  • what you should know about this drug before using it,
  • other drugs that may interact with this drug, and
  • possible side effects.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Targeted Cancer Therapies 5 - Information about the use of this drug to treat cancer.

Biological Therapies for Cancer: Questions and Answers 6 - Information about the use of this drug to treat cancer.

Research Results

The Making of a Monoclonal Antibody 7 - Information about the use of this drug to treat cancer.

Clinical Trials Accepting Patients

Find Clinical Trials for Tositumomab And Iodine I 131 Tositumomab 8 - Check for trials from NCI's list of cancer clinical trials now accepting patients.

Important: The drug information on this page is meant to be educational. It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.


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Glossary Terms

cancer (KAN-ser)
A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
chemotherapy (KEE-moh-THAYR-uh-pee)
Treatment with drugs that kill cancer cells.
non-Hodgkin lymphoma (non-HOJ-kin lim-FOH-muh)
Any of a large group of cancers of lymphocytes (white blood cells). Non-Hodgkin lymphomas can occur at any age and are often marked by lymph nodes that are larger than normal, fever, and weight loss. There are many different types of non-Hodgkin lymphoma. These types can be divided into aggressive (fast-growing) and indolent (slow-growing) types, and they can be formed from either B-cells or T-cells. B-cell non-Hodgkin lymphomas include Burkitt lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell non-Hodgkin lymphomas include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas that occur after bone marrow or stem cell transplantation are usually B-cell non-Hodgkin lymphomas. Prognosis and treatment depend on the stage and type of disease. Also called NHL.
radioimmunotherapy (RAY-dee-oh-IH-myoo-noh-THAYR-uh-pee)
A type of systemic radiation therapy in which a radioactive substance is linked to an antibody that locates and kills tumor cells when injected into the body.
relapse (REE-laps)
The return of a disease or the signs and symptoms of a disease after a period of improvement.
rituximab (rih-TUK-sih-mab)
A drug used to treat certain types of B-cell non-Hodgkin lymphoma. It is also used with other drugs to treat chronic lymphocytic leukemia and rheumatoid arthritis. It is being studied in the treatment of other types of cancer and other conditions. Rituximab binds to a protein called CD20, which is found on B-cells, and may kill cancer cells. It is a type of monoclonal antibody. Also called Rituxan.

Table of Links

1http://www.cancer.gov/PublishedContent/Media/CDR/Media/720800.mp3
2http://www.cancer.gov/cancertopics/druginfo/fda-tositumomab-I131iodine-tositumo
mab
3http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=588881
4http://www.nlm.nih.gov/medlineplus/druginfo/meds/a609013.html
5http://www.cancer.gov/cancertopics/factsheet/Therapy/targeted
6http://www.cancer.gov/cancertopics/factsheet/Therapy/biological
7http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_061306/page4
8http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=588881&idtype=1
9http://www.cancer.gov/cancertopics/druginfo/alphalist
10http://www.cancer.gov/cancertopics/druginfo/drug-page-index
11http://www.cancer.gov/clinicaltrials/learningabout/approval-process-for-cancer-
drugs
12http://www.cancer.gov/cancertopics/factsheet/Therapy/investigational-drug-access