Questions About Cancer? 1-800-4-CANCER
National Cancer Institute Fact Sheet
  • Reviewed: 01/12/2011

Secondhand Smoke and Cancer

Key Points

  • Secondhand smoke (also called environmental tobacco smoke, involuntary smoke, and passive smoke) is the smoke given off by a burning tobacco product and the smoke exhaled by a smoker.
  • At least 69 chemicals in secondhand smoke are known to cause cancer.
  • Secondhand smoke causes lung cancer in nonsmokers.
  • Secondhand smoke has also been associated with heart disease in adults and sudden infant death syndrome, ear infections, and asthma attacks in children.
  • There is no safe level of exposure to secondhand smoke.
  1. What is secondhand smoke?

    Secondhand smoke (also called environmental tobacco smoke, involuntary smoke, and passive smoke) is the combination of “sidestream” smoke (the smoke given off by a burning tobacco product) and “mainstream” smoke (the smoke exhaled by a smoker) (14).

    People can be exposed to secondhand smoke in homes, cars, the workplace, and public places, such as bars, restaurants, and recreational settings. In the United States, the source of most secondhand smoke is from cigarettes, followed by pipes, cigars, and other tobacco products (4).

    The amount of smoke created by a tobacco product depends on the amount of tobacco available for burning. The amount of secondhand smoke emitted by smoking one large cigar is similar to that emitted by smoking an entire pack of cigarettes.

  2. How is secondhand smoke exposure measured?

    Secondhand smoke exposure can be measured by testing indoor air for nicotine or other chemicals in tobacco smoke. Exposure to secondhand smoke can also be tested by measuring the level of cotinine (a by-product of the breakdown of nicotine) in a nonsmoker’s blood, saliva, or urine (1). Nicotine, cotinine, carbon monoxide, and other smoke-related chemicals have been found in the body fluids of nonsmokers exposed to secondhand smoke.

  3. Does secondhand smoke contain harmful chemicals?

    Yes. Among the more than 7,000 chemicals that have been identified in secondhand tobacco smoke, at least 250 are known to be harmful, for example, hydrogen cyanide, carbon monoxide, and ammonia.

    At least 69 of the toxic chemicals in secondhand tobacco smoke cause cancer (1, 5, 6). These include the following:

    Other toxic chemicals in secondhand smoke are suspected to cause cancer, including (1):

    Many factors affect which chemicals are found in secondhand smoke, such as the type of tobacco, the chemicals added to the tobacco, the way the tobacco product is smoked, and, for cigarettes and cigars, the material in which the tobacco is wrapped (1, 3, 4).

  4. Does exposure to secondhand smoke cause cancer?

    Yes. The U.S. Environmental Protection Agency, the U.S. National Toxicology Program, the U.S. Surgeon General, and the International Agency for Research on Cancer have all classified secondhand smoke as a known human carcinogen (a cancer-causing agent) (1, 3, 5, 7).

    Inhaling secondhand smoke causes lung cancer in nonsmoking adults (4, 5). Approximately 3,000 lung cancer deaths occur each year among adult nonsmokers in the United States as a result of exposure to secondhand smoke (2). The U.S. Surgeon General estimates that living with a smoker increases a nonsmoker’s chances of developing lung cancer by 20 to 30 percent (4).

    Some research also suggests that secondhand smoke may increase the risk of breast cancer, nasal sinus cavity cancer, and nasopharyngeal cancer in adults and the risk of leukemia, lymphoma, and brain tumors in children (4). Additional research is needed to learn whether a link exists between secondhand smoke exposure and these cancers.

  5. What are the other health effects of exposure to secondhand smoke?

    Secondhand smoke is associated with disease and premature death in nonsmoking adults and children (4, 5). Exposure to secondhand smoke irritates the airways and has immediate harmful effects on a person’s heart and blood vessels. It may increase the risk of heart disease by an estimated 25 to 30 percent (4). In the United States, secondhand smoke is thought to cause about 46,000 heart disease deaths each year (8). There may also be a link between exposure to secondhand smoke and the risk of stroke and hardening of the arteries; however, additional research is needed to confirm this link.

    Children exposed to secondhand smoke are at increased risk of sudden infant death syndrome, ear infections, colds, pneumonia, bronchitis, and more severe asthma. Being exposed to secondhand smoke slows the growth of children’s lungs and can cause them to cough, wheeze, and feel breathless (4, 5).

  6. What is a safe level of secondhand smoke?

    There is no safe level of exposure to secondhand smoke. Even low levels of secondhand smoke can be harmful. The only way to fully protect nonsmokers from secondhand smoke is to completely eliminate smoking in indoor spaces. Separating smokers from nonsmokers, cleaning the air, and ventilating buildings cannot completely eliminate exposure to secondhand smoke (4).

  7. What is being done to reduce nonsmokers’ exposure to secondhand smoke?

    On the national level, several laws restricting smoking in public places have been passed. Federal law bans smoking on domestic airline flights, nearly all flights between the United States and foreign destinations, interstate buses, and most trains. Smoking is also banned in most federally owned buildings. The Pro-Children Act of 1994 prohibits smoking in facilities that routinely provide federally funded services to children.

    Many state and local governments have passed laws prohibiting smoking in public facilities, such as schools, hospitals, airports, bus terminals, parks, and beaches, as well as private workplaces, including restaurants and bars. Some states have passed laws regulating smoking in multiunit housing and cars. More than half of the states have enacted statewide bans on workplace smoking.

    To highlight the health risks from secondhand smoke, the National Cancer Institute, a component of the National Institutes of Health, holds meetings and conferences in states, counties, cities, or towns that are smoke free, unless specific circumstances justify an exception to this policy. More information is available at http://meetings.smokefree.gov/ on the Internet.

    The U.S. Department of Health and Human Services Healthy People 2020, a comprehensive, nationwide health promotion and disease prevention agenda, includes the goal of reducing illness, disability, and death related to tobacco use and secondhand smoke exposure. Currently, most Americans are exposed to secondhand smoke, and children are at greatest risk. For 2020, the goal is to reduce the proportion of people exposed to secondhand smoke by 10 percent. To assist with achieving this goal, Healthy People 2020 includes ideas for community interventions, such as encouraging the introduction of smoke-free policies in workplaces and other public areas.

    More information about this program is available on the Healthy People 2020 Web site at http://www.healthypeople.gov/ on the Internet.

    Internationally, a growing number of nations, including France, Ireland, New Zealand, Norway, and Uruguay, require all workplaces, including bars and restaurants, to be smoke free.

Selected References
  1. National Toxicology Program. Report on Carcinogens. Eleventh Edition. U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2005.
  2. National Cancer Institute. Cancer Progress Report 2003. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, 2004.
  3. International Agency for Research on Cancer. Tobacco Smoke and Involuntary Smoking. Lyon, France: 2002. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 83.
  4. U.S. Department of Health and Human Services. The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General. Rockville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2006.
  5. U.S. Department of Health and Human Services. How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2010.
  6. National Cancer Institute. Health Effects of Exposure to Environmental Tobacco Smoke. Bethesda, MD: National Cancer Institute; 1999. Smoking and Tobacco Control Monograph 10.
  7. U.S. Environmental Protection Agency. Respiratory Health Effects of Passive Smoking (Also Known as Exposure to Secondhand Smoke or Environmental Tobacco Smoke—ETS). U.S. Environmental Protection Agency, 1992.
  8. California Environmental Protection Agency, Office of Environmental Health Hazard Assessment. Proposed Identification of Environmental Tobacco Smoke as a Toxic Air Contaminant: Part B Health Effects, 2005.


Glossary Terms

arsenic (ARS-nik)
A poisonous chemical used to kill weeds and pests. Also used in cancer therapy.
benzene (BEN-zeen)
A chemical that is used widely by the chemical industry, and is also found in tobacco smoke, vehicle emissions, and gasoline fumes. Exposure to benzene may increase the risk of developing leukemia.
benzo(a)pyrene (BEN-zoh-ay-PY-reen)
A chemical that comes from certain substances when they are not burned completely. It is found in car exhaust, smoke from wood fires, tobacco, oil and gas products, charred or grilled foods, and other sources. It may also be found in water and soil. Benzo(a)pyrene can cause a skin rash, a burning feeling, skin color changes, warts, and bronchitis. It may also cause cancer. It is a type of polycyclic aromatic hydrocarbon. Also called 3,4-benzpyrene.
bronchitis (bron-KY-tis)
Inflammation (swelling and reddening) of the bronchi.
cadmium (KAD-mee-um)
A metallic element that occurs naturally in tiny amounts in air, water, soil, and food. It is a byproduct of zinc refining, and is used to make batteries, pigments, plastics, alloys, and electroplate. It is also found in cigarette smoke. Exposure to high levels of cadmium may cause certain cancers and other health problems.
carbon monoxide (KAR-bun muh-NOK-side)
A poisonous gas that has no color or odor. It is given off by burning fuel (as in exhaust from cars or household heaters) and tobacco products. Carbon monoxide prevents red blood cells from carrying enough oxygen for cells and tissues to live.
cyanide (SY-uh-nide)
A poisonous chemical found in some foods and plants, tobacco smoke, and when certain substances are burned. It is used to make products such as paper, fabric, and plastic, and is used as a pesticide. Cyanide keeps cells in the body from using oxygen, so they die. Exposure to cyanide may cause serious health effects, including death.
ethylene oxide (EH-thuh-leen OK-side)
A chemical used to make antifreeze, to clean medical equipment, and as a pesticide. It is also found in tobacco smoke. Being exposed to ethylene oxide can cause lung damage, headache, nausea, vomiting, diarrhea, and shortness of breath. Being exposed over a long time may increase the risk of certain types of cancer.
formaldehyde (for-MAL-deh-hide)
A chemical used in manufacturing and chemical industries, and as a preservative by anatomists, embalmers, and pathologists. Being exposed to formaldehyde may increase the risk of developing leukemia and brain cancer.
leukemia (loo-KEE-mee-uh)
Cancer that starts in blood-forming tissue such as the bone marrow and causes large numbers of blood cells to be produced and enter the bloodstream.
lymphoma (lim-FOH-muh)
Cancer that begins in cells of the immune system. There are two basic categories of lymphomas. One kind is Hodgkin lymphoma, which is marked by the presence of a type of cell called the Reed-Sternberg cell. The other category is non-Hodgkin lymphomas, which includes a large, diverse group of cancers of immune system cells. Non-Hodgkin lymphomas can be further divided into cancers that have an indolent (slow-growing) course and those that have an aggressive (fast-growing) course. These subtypes behave and respond to treatment differently. Both Hodgkin and non-Hodgkin lymphomas can occur in children and adults, and prognosis and treatment depend on the stage and the type of cancer.
nasopharyngeal cancer (NAY-zoh-fuh-RIN-jee-ul KAN-ser)
Cancer that forms in tissues of the nasopharynx (upper part of the throat behind the nose). Most nasopharyngeal cancers are squamous cell carcinomas (cancer that begins in flat cells lining the nasopharynx).
nicotine (NIH-kuh-TEEN)
An addictive, poisonous chemical found in tobacco. It can also be made in the laboratory. When it enters the body, nicotine causes an increased heart rate and use of oxygen by the heart, and a sense of well-being and relaxation. It is also used as an insecticide.
pneumonia (noo-MOH-nyuh)
A severe inflammation of the lungs in which the alveoli (tiny air sacs) are filled with fluid. This may cause a decrease in the amount of oxygen that blood can absorb from air breathed into the lung. Pneumonia is usually caused by infection but may also be caused by radiation therapy, allergy, or irritation of lung tissue by inhaled substances. It may involve part or all of the lungs.
toluene (TOL-yoo-een)
A strong-smelling, colorless liquid used to make gasoline and other types of fuel, paint, paint thinner, fingernail polish, glue, and rubber. Being exposed to toluene may cause headache, tiredness, confusion, weakness, memory loss, nausea, loss of appetite, hearing and color vision loss, dizziness, loss of consciousness, kidney damage, and death.
vinyl chloride (VY-nil KLOR-ide)
A substance used to make plastics. Exposure to vinyl chloride may increase the risk of developing liver, brain, and lung cancers; lymphoma; and leukemia.

Table of Links

1http://www.cancer.gov/cancertopics/factsheet/Tobacco/smokeless
2http://www.cancer.gov/cancertopics/factsheet/Tobacco/light-cigarettes
3http://www.cancer.gov/cancertopics/factsheet/Tobacco/symptoms-triggers-quitting
4http://www.cancer.gov/cancertopics/factsheet/Tobacco/help-quitting
5http://www.smokefree.gov/pubs/clearing-the-air_acc.pdf