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Topics in Complementary and Alternative Therapies (PDQ®)

Health Professional Version

Pharmacologic Treatments


714-X is naturally derived camphor that is chemically modified by the introduction of a nitrogen atom. It is claimed that 714-X protects and stabilizes the immune system and restores its ability to fight cancer. No study of 714-X has been published in a peer-reviewed scientific journal to show its safety or effectiveness in treating cancer. Refer to the PDQ summary on 714-X for more information.


Antineoplastons are drugs composed of chemical compounds that are naturally present in the urine and blood. They are an experimental cancer therapy that is purported to provide a natural biochemical substance that is excreted and therefore lacking in people with cancer. Antineoplastons therapy for cancer patients is currently available only in the United States and only to the patients of its developer. Refer to the PDQ summary on Antineoplastons for more information.


Cancell/Cantron/Protocel—also known by the names Sheridan’s Formula, Jim’s Juice, JS-114, JS-101, 126-F, and the "Cancell-like" products Cantron and Protocel—is a liquid that has been produced in various forms principally by two manufacturers since the late 1930s. The exact composition of Cancell/Cantron/Protocel is unknown and not effective in treating any type of cancer. Refer to the PDQ summary on Cancell/Cantron/Protocel for more information.

Cartilage (Bovine and Shark)

Bovine (cow) cartilage and shark cartilage have been studied as treatments for people with cancer and other medical conditions for more than 30 years. At least three different inhibitors of angiogenesis have been identified in bovine cartilage, and two angiogenesis inhibitors have been purified from shark cartilage. Refer to the PDQ summary on Cartilage (Bovine and Shark) for more information.

Hydrazine Sulfate

Hydrazine sulfate is a chemical that has been studied as a treatment for cancer and as a treatment for the body wasting (i.e., cachexia) associated with this disease. It has been claimed that hydrazine sulfate limits the ability of tumors to obtain glucose, which is a type of sugar used by cells to create energy. Refer to the PDQ summary on Hydrazine Sulfate for more information.


Laetrile is another name for the chemical amygdalin, which is found in the pits of many fruits and in numerous plants. Cyanide is thought to be the main anticancer component of laetrile. Laetrile has shown little anticancer activity in animal studies and no anticancer activity in human clinical trials. Refer to the PDQ summary on Laetrile/Amygdalin for more information.

Newcastle Disease Virus (NDV)

NDV is a paramyxovirus that causes Newcastle disease in a wide variety of birds (most notably, in chickens). Although NDV causes a potentially fatal, noncancerous disease (Newcastle disease) in birds, it causes only minor illness in humans. NDV appears to replicate (i.e., reproduce) substantially better in human cancer cells than it does in most normal human cells. Refer to the PDQ summary on Newcastle Disease Virus for more information.

  • Updated: April 13, 2015