In English | En español
Questions About Cancer? 1-800-4-CANCER

Genetics of Colorectal Cancer (PDQ®)

  • Updated: 11/12/2014

Table 3. Colorectal Cancer Susceptibility Loci Identified Through Genome-Wide Association Studies

Chromosome Logarithm of the Odds (LOD) Score/Odds Ratio (OR)  P Value Single Nucleotide Polymorphism (SNP) Marker 
3q29LOD = 2.61 [27].0003D3S240
4q31.3LOD = 2.13 [27].0009D4S2999
7q31.31LOD = 3.08 [27].00008D7S643
8q23.3Combined OR = 1.29 [24]1.1 × 10-10rs11986063
8q23.3ORallelic = 1.25, ORhet = 1.27, ORhom = 1.43 [22]3.3 × 10-18rs16892766
Combined OR = 1.32 [24]1.1 × 10-10
8q24ORallelic = 1.24, ORhet = 1.35, ORhom = 1.57 [22]7.0 × 10-11rs6983267
Combined OR = 0.83 [24]2.1 × 10-14
8q24OR = 1.19 [23]8.6 × 10-26rs7014346
Combined OR = 1.21 [24]3.0 × 10-13
8q24Combined OR = 1.17 [24]1.2 × 10-10rs7837328
8q24Combined OR = 1.14 [24]1.5 × 10-7rs10808555
10p14ORallelic = 0.89, ORhet = 0.87, ORhom = 0.80 [22]2.5 × 10-13rs10795668
Combined OR = 0.91 [24]3.1 × 10-4
11q23OR = 1.11 [23]5.8 × 10-10rs3802842
Combined OR = 1.21 [24]5.2 × 10-13
14q22.2Combined OR = 1.11 [24]8.1 × 10-10rs4444235
15q13ORallelic = 1.23, ORhet = 1.17, ORhom = 1.70 [22]4.7 × 10-7rs4779584
Combined OR = 1.19 [24]1.7 × 10-8
16q22.1Combined OR = 0.91 [24]1.2 × 10-8rs9929218
17p13.3aNot available [26].0364D17S1308
18q21ORallelic = 0.85, ORhet = 0.84, ORhom = 0.73 [22]1.7 × 10-6rs4939827
OR = 1.20 [23]7.8 × 10-28
Combined OR = 0.85 [24]2.2 × 10-11
19q13.1Combined OR = 0.89 [24]2.2 × 10-7rs7259371
19q13.1Combined OR = 0.87 [24]4.6 × 10-9rs10411210
20p12.3Combined OR = 1.12 [24]2.0 × 10-10 rs355527
20p12.3Combined OR = 1.12 [24]2.1 10-10rs961253

ORhet = odds ratio among heterozygotes; ORhom = odds ratio among homozygotes.
aIdentified in a breast/colon cohort.

References

  1. Tomlinson IP, Webb E, Carvajal-Carmona L, et al.: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet 40 (5): 623-30, 2008.  [PUBMED Abstract]

  2. Tenesa A, Farrington SM, Prendergast JG, et al.: Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 40 (5): 631-7, 2008.  [PUBMED Abstract]

  3. Houlston RS, Webb E, Broderick P, et al.: Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet 40 (12): 1426-35, 2008.  [PUBMED Abstract]

  4. Daley D, Lewis S, Platzer P, et al.: Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet 82 (3): 723-36, 2008.  [PUBMED Abstract]

  5. Neklason DW, Kerber RA, Nilson DB, et al.: Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis. Cancer Res 68 (21): 8993-7, 2008.  [PUBMED Abstract]