Table 3. Colorectal Cancer Susceptibility Loci Identified Through Genome-Wide Association Studies
| Chromosome | Logarithm of the Odds (LOD) Score/Odds Ratio (OR) | P Value | Single Nucleotide Polymorphism (SNP) | Marker |
| 3q29 | LOD = 2.61 [16] | .0003 | D3S240 | |
| 4q31.3 | LOD = 2.13 [16] | .0009 | D4S2999 | |
| 7q31.31 | LOD = 3.08 [16] | .00008 | D7S643 | |
| 8q23.3 | Combined OR = 1.29 [13] | 1.1 × 10-10 | rs11986063 | |
| 8q23.3 | ORallelic = 1.25, ORhet = 1.27, ORhom = 1.43 [11] | 3.3 × 10-18 | rs16892766 | |
| Combined OR = 1.32 [13] | 1.1 × 10-10 | |||
| 8q24 | ORallelic = 1.24, ORhet = 1.35, ORhom = 1.57 [11] | 7.0 × 10-11 | rs6983267 | |
| Combined OR = 0.83 [13] | 2.1 × 10-14 | |||
| 8q24 | OR = 1.19 [12] | 8.6 × 10-26 | rs7014346 | |
| Combined OR = 1.21 [13] | 3.0 × 10-13 | |||
| 8q24 | Combined OR = 1.17 [13] | 1.2 × 10-10 | rs7837328 | |
| 8q24 | Combined OR = 1.14 [13] | 1.5 × 10-7 | rs10808555 | |
| 10p14 | ORallelic = 0.89, ORhet = 0.87, ORhom = 0.80 [11] | 2.5 × 10-13 | rs10795668 | |
| Combined OR = 0.91 [13] | 3.1 × 10-4 | |||
| 11q23 | OR = 1.11 [12] | 5.8 × 10-10 | rs3802842 | |
| Combined OR = 1.21 [13] | 5.2 × 10-13 | |||
| 14q22.2 | Combined OR = 1.11 [13] | 8.1 × 10-10 | rs4444235 | |
| 15q13 | ORallelic = 1.23, ORhet = 1.17, ORhom = 1.70 [11] | 4.7 × 10-7 | rs4779584 | |
| Combined OR = 1.19 [13] | 1.7 × 10-8 | |||
| 16q22.1 | Combined OR = 0.91 [13] | 1.2 × 10-8 | rs9929218 | |
| 17p13.3a | Not available [15] | .0364 | D17S1308 | |
| 18q21 | ORallelic = 0.85, ORhet = 0.84, ORhom = 0.73 [11] | 1.7 × 10-6 | rs4939827 | |
| OR = 1.20 [12] | 7.8 × 10-28 | |||
| Combined OR = 0.85 [13] | 2.2 × 10-11 | |||
| 19q13.1 | Combined OR = 0.89 [13] | 2.2 × 10-7 | rs7259371 | |
| 19q13.1 | Combined OR = 0.87 [13] | 4.6 × 10-9 | rs10411210 | |
| 20p12.3 | Combined OR = 1.12 [13] | 2.0 × 10-10 | rs355527 | |
| 20p12.3 | Combined OR = 1.12 [13] | 2.1 10-10 | rs961253 |
| ORhet = odds ratio among heterozygotes; ORhom = odds ratio among homozygotes. | ||
| aIdentified in a breast/colon cohort. |
References
- Tomlinson IP, Webb E, Carvajal-Carmona L, et al.: A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet 40 (5): 623-30, 2008. [PUBMED Abstract]
- Tenesa A, Farrington SM, Prendergast JG, et al.: Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 40 (5): 631-7, 2008. [PUBMED Abstract]
- Houlston RS, Webb E, Broderick P, et al.: Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet 40 (12): 1426-35, 2008. [PUBMED Abstract]
- Daley D, Lewis S, Platzer P, et al.: Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet 82 (3): 723-36, 2008. [PUBMED Abstract]
- Neklason DW, Kerber RA, Nilson DB, et al.: Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis. Cancer Res 68 (21): 8993-7, 2008. [PUBMED Abstract]
