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Breast Cancer Prevention (PDQ®)

  • Updated: 09/19/2014

Incidence of Outcomes Per 1,000 Women

 Tamoxifen Raloxifene RR, 95% CI 
CI = confidence interval; RR = relative risk; VTE = venous thromboembolism.
Invasive breast cancer4.34.411.02, 0.82–1.28
Noninvasive breast cancer1.512.111.4, 0.98–2.00
Uterine cancer2.01.250.62, 0.35–1.08
VTE3.82.60.7, 0.68–0.99
Cataracts12.39.720.79, 0.68–0.92
Incidence of Symptoms (0–4 scale)
Favor Tamoxifen
Dyspareunia0.680.78P < .001
Musculoskeletal problems1.101.15P = .002
Weight gain0.760.82P < .001
Favor Raloxifene
Vasomotor symptoms0.960.85P < .001
Bladder control symptoms0.880.73P < .001
Leg cramps1.100.91P < .001
Gynecologic problems0.290.19P < .001