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Endometrial Cancer Prevention (PDQ®)

Health Professional Version

Changes to This Summary (01/30/2015)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Who Is at Risk?

Added text to state that women with a family history of endometrial cancer in a first-degree relative are also at increased risk.


Revised text to state that this excess risk of endometrial cancer associated with postmenopausal unopposed estrogen therapy can be eliminated by adding continuous progestin to estrogen therapy, but this is associated with an increased risk of breast cancer (cited Brinton et al., Trabert et al., Allen et al., and Beral et al. as references 13, 14, 15, and 16, respectively).

Description of Evidence

Updated statistics with estimated new cases and deaths for 2015 (cited American Cancer Society as reference 1).

Added text about the Million Women Study, a cohort study conducted in the United Kingdom in more than one million women aged 50 to 64 years, which observed a statistically significant decreased risk of endometrial cancer associated with continuous combined estrogen-progestin therapy, compared with never-users; a similar finding was observed in the European Prospective Investigation into Cancer and Nutrition cohort, with a decreased risk associated with continuous estrogen-progestin therapy, but this association was based on only three exposed cases. Also added that these observed risks were similar to those observed in the NIH-AARP Diet and Health Study Cohort (cited Beral et al., Allen et al., and Trabert et al. as references 49, 50, and 51, respectively).

This summary is written and maintained by the PDQ Screening and Prevention Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

  • Updated: January 30, 2015