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Cervical Cancer Treatment (PDQ®)

  • Updated: 03/14/2014

Table 1. Carcinoma of the Cervix Uteria

Stage  
IThe carcinoma is strictly confined to the cervix (extension to the corpus would be disregarded).
IAInvasive carcinoma, which can be diagnosed only by microscopy with deepest invasion ≤5 mm and largest extension ≥7 mm.
IA1Measured stromal invasion of ≤3.0 mm in depth and extension of ≤7.0 mm.
IA2Measured stromal invasion of >3.0 mm and not >5.0 mm with an extension of not >7.0 mm.
IBClinically visible lesions limited to the cervix uteri or preclinical cancers greater than stage IA.b
IB1Clinically visible lesion ≤4.0 cm in greatest dimension.
IB2Clinically visible lesion >4.0 cm in greatest dimension.
IICervical carcinoma invades beyond the uterus but not to the pelvic wall or to the lower third of the vagina.
IIAWithout parametrial invasion.
IIA1Clinically visible lesion ≤4.0 cm in greatest dimension.
IIA2Clinically visible lesion >4.0 cm in greatest dimension.
IIBWith obvious parametrial invasion.
IIIThe tumor extends to the pelvic wall and/or involves lower third of the vagina and/or causes hydronephrosis or nonfunctioning kidney.c
IIIATumor involves lower third of the vagina with no extension to the pelvic wall.
IIIBExtension to the pelvic wall and/or hydronephrosis or nonfunctioning kidney.
IVThe carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. A bullous edema, as such, does not permit a case to be allotted to stage IV.
IVASpread of the growth to adjacent organs.
IVBSpread to distant organs.

aAdapted from FIGO Committee on Gynecologic Oncology.[2]
bAll macroscopically visible lesions—even with superficial invasion—are allotted to stage IB carcinomas. Invasion is limited to a measured stromal invasion with a maximal depth of 5.00 mm and a horizontal extension of not >7.00 mm. Depth of invasion should not be >5.00 mm taken from the base of the epithelium of the original tissue—superficial or glandular. The depth of invasion should always be reported in mm, even in those cases with "early (minimal) stromal invasion" (~1 mm).
The involvement of vascular/lymphatic spaces should not change the stage allotment.
cOn rectal examination, there is no cancer-free space between the tumor and the pelvic wall. All cases with hydronephrosis or nonfunctioning kidney are included, unless they are known to be the result of another cause.

References

  1. Pecorelli S: Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 105 (2): 103-4, 2009.  [PUBMED Abstract]