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Childhood Extracranial Germ Cell Tumors Treatment (PDQ®)

  • Updated: 06/06/2014

Table 4. Comparison of Adult BEP and Pediatric PEB and JEB Chemotherapy Dosing Schedulesa

Regimen Bleomycin Etoposide Cisplatin Carboplatin 
Adult BEP (every 21 days)b [15,18]30 units/m2, days 1, 8, 15100mg/m2, days 1–520 mg/m2, days 1–5
Pediatric PEB (every 21 days) [1,2]15 units/m², day 1100 mg/m², days 1–520 mg/m², days 1–5
Pediatric JEB (every 21–28 days) [3]15 units/m², day 3120 mg/m², days 1–3600 mg/m² or GFR-based dosing, day 2

BEP = bleomycin, etoposide, and cisplatin; GFR = glomerular filtration rate; JEB = carboplatin, etoposide, and bleomycin; PEB = cisplatin, etoposide, and bleomycin.
aAdult doses of PEB and JEB chemotherapy are different from pediatric doses.
bThe adult BEP regimen is provided here for comparison only; BEP is not used in the treatment of children.

References

  1. Rogers PC, Olson TA, Cullen JW, et al.: Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: A Pediatric Intergroup Study--Pediatric Oncology Group 9048 and Children's Cancer Group 8891. J Clin Oncol 22 (17): 3563-9, 2004.  [PUBMED Abstract]

  2. Cushing B, Giller R, Cullen JW, et al.: Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study--Pediatric Oncology Group 9049 and Children's Cancer Group 8882. J Clin Oncol 22 (13): 2691-700, 2004.  [PUBMED Abstract]

  3. Mann JR, Raafat F, Robinson K, et al.: The United Kingdom Children's Cancer Study Group's second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol 18 (22): 3809-18, 2000.  [PUBMED Abstract]

  4. Williams SD, Birch R, Einhorn LH, et al.: Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med 316 (23): 1435-40, 1987.  [PUBMED Abstract]

  5. Einhorn LH, Williams SD, Loehrer PJ, et al.: Evaluation of optimal duration of chemotherapy in favorable-prognosis disseminated germ cell tumors: a Southeastern Cancer Study Group protocol. J Clin Oncol 7 (3): 387-91, 1989.  [PUBMED Abstract]