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Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®)

  • Updated: 03/07/2014

Table 1. Endocrine Tumors of the Pancreas

Islet Cells Secreted Active Agent Tumor and Syndrome 
ACTH = adrenocorticotropin; MSH = melanocyte-stimulating hormone; VIP = vasoactive intestinal peptide; WDHA = watery diarrhea, hypokalemia, and achlorhydria; 5-HT = serotonin.
AlphaGlucagonGlucagonoma (diabetes, dermatitis)
BetaInsulinInsulinoma (hypoglycemia)
DeltaSomatostatinSomatostatinoma (mild diabetes); diarrhea/steatorrhea; gallstones
DGastrinGastrinoma (peptic ulcer disease)
A -> DVIP and/or other undefined mediatorsWDHA
5-HT
ACTH
MSHCarcinoid
Cushing syndrome
Hyperpigmentation
Interacinar Cells Secreted Active Agent Tumor and Syndrome
FPancreatic polypeptideMultiple hormonal syndromes
EC5-HTCarcinoid