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Laryngeal Cancer Treatment (PDQ®)

  • Last Modified: 04/15/2014

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Changes to This Summary (04/15/2014)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

General Information About Laryngeal Cancer

Revised text to state that locally advanced lesions are treated with combined modality therapy involving radiation and chemotherapy with or without surgery, the aim of which is laryngeal preservation in appropriately selected candidates (cited Forastiere et al. as reference 8).

Treatment Option Overview

This section was extensively revised.

Stage I Laryngeal Cancer

Added Lucioni et al. as reference 8.

Stage III Laryngeal Cancer

Added Forastiere et al. as reference 1.

Added text to the list of standard treatment options for stage III cancer of the supraglottis to include induction chemotherapy followed by concomitant chemotherapy and radiation.

Revised text in the list of standard treatment options for stage III cancer of the supraglottis to include definitive radiation therapy alone in patients who are not candidates for concomitant chemotherapy and surgery for salvage of radiation failures.

Revised text in the list of standard treatment options for stage III cancer of the supraglottis to include surgery with or without postoperative radiation therapy (cited The Department of Veterans Affairs Laryngeal Cancer Study Group as reference 9).

Added text to the list of standard treatment options for stage III cancer of the glottis to include induction chemotherapy followed by concomitant chemotherapy and radiation.

Revised text in the list of standard treatment options for stage III cancer of the glottis to include definitive radiation therapy alone in patients who are not candidates for concomitant chemotherapy and surgery for salvage of radiation failures.

Revised text in the list of standard treatment options for stage III cancer of the glottis to include surgery with or without postoperative radiation therapy.

Stage IV Laryngeal Cancer

Revised text in the list of standard treatment options for stage IV cancer of the supraglottis to include chemotherapy administered concomitantly with radiation therapy for patients who would require total laryngectomy for control of disease, including those with nonbulky T4a disease (cited Forastiere et al. as reference 1).

Added text to the list of standard treatment options for stage IV cancer of the supraglottis to include induction chemotherapy followed by concomitant chemotherapy and radiation.

Revised text in the list of standard treatment options for stage IV cancer of the supraglottis to include definitive radiation therapy alone in patients who are not candidates for concomitant chemotherapy and surgery for salvage of radiation failures

Revised text in the list of standard treatment options for stage IV cancer of the supraglottis to include the option for patients with bulky T4 disease of surgery with postoperative radiation therapy with or without concomitant chemotherapy based on pathological adverse features (cited Bernier et al. as reference 9).

Revised text in the list of standard treatment options for stage IV cancer of the glottis to include chemotherapy administered concomitantly with radiation therapy for patients who would require total laryngectomy for control of disease, including those with nonbulky T4a disease.

Added text to the list of standard treatment options for stage IV cancer of the glottis to include induction chemotherapy followed by concomitant chemotherapy and radiation.

Revised text in the list of standard treatment options for stage IV cancer of the glottis to include definitive radiation therapy alone in patients who are not candidates for concomitant chemotherapy and surgery for salvage of radiation failures.

Revised text in the list of standard treatment options for stage IV cancer of the glottis to include the option for patients with bulky T4 disease of surgery with postoperative radiation therapy with or without concomitant chemotherapy based on pathological adverse features.

This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.