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Laryngeal Cancer Treatment (PDQ®)

Patient Version
Last Modified: 06/20/2014

Treatment Options by Stage

Stage I Laryngeal Cancer
Stage II Laryngeal Cancer
Stage III Laryngeal Cancer
Stage IV Laryngeal Cancer



Stage I Laryngeal Cancer

Treatment of stage I laryngeal cancer depends on where cancer is found in the larynx.

If cancer is in the supraglottis, treatment may include the following:

If cancer is in the glottis, treatment may include the following:

If cancer is in the subglottis, treatment may include the following:

  • Radiation therapy with or without surgery.
  • Surgery alone.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I laryngeal cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Stage II Laryngeal Cancer

Treatment of stage II laryngeal cancer depends on where cancer is found in the larynx.

If cancer is in the supraglottis, treatment may include the following:

If cancer is in the glottis, treatment may include the following:

If cancer is in the subglottis, treatment may include the following:

  • Radiation therapy with or without surgery.
  • Surgery alone.
  • A clinical trial of radiation therapy.
  • A clinical trial of chemoprevention.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage II laryngeal cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Stage III Laryngeal Cancer

Treatment of stage III laryngeal cancer depends on where cancer is found in the larynx.

If cancer is in the supraglottis or glottis, treatment may include the following:

If cancer is in the subglottis, treatment may include the following:

  • Laryngectomy plus total thyroidectomy and removal of lymph nodes in the throat, usually followed by radiation therapy.
  • Radiation therapy with or without surgery.
  • A clinical trial of chemotherapy, radiosensitizers, or radiation therapy.
  • A clinical trial of chemoprevention.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III laryngeal cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Stage IV Laryngeal Cancer

Treatment of stage IV laryngeal cancer depends on where cancer is found in the larynx.

If cancer is in the supraglottis or glottis, treatment may include the following:

If cancer is in the subglottis, treatment may include the following:

  • Laryngectomy plus total thyroidectomy and removal of lymph nodes in the throat, usually with radiation therapy.
  • Radiation therapy.
  • A clinical trial of radiation therapy.
  • A clinical trial of chemotherapy, radiosensitizers, or radiation therapy.
  • A clinical trial of chemoprevention.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage IV laryngeal cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.