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Late Effects of Treatment for Childhood Cancer (PDQ®)

  • Posted: 04/23/2004
  • Updated: 08/18/2014

Table 9. Pituitary Gland Late Effects

Predisposing Therapy Endocrine/Metabolic Effects  Health Screening 
BMI = body mass index; FSH = follicle-stimulating hormone; LH = luteinizing hormone.
Radiation impacting hypothalamic-pituitary axisGrowth hormone deficiencyAssessment of nutritional status
Height, weight, BMI, Tanner stage
Radiation impacting hypothalamic-pituitary axisPrecocious pubertyHeight, weight, BMI, Tanner stage
Radiation impacting hypothalamic-pituitary axisGonadotropin deficiencyHistory: puberty, sexual function
Exam: Tanner stage
FSH, LH, estradiol or testosterone levels
Radiation impacting hypothalamic-pituitary axisCentral adrenal insufficiencyHistory: failure to thrive, anorexia, episodic dehydration, hypoglycemia, lethargy, unexplained hypotension
Endocrine consultation for those with radiation dose ≥30 Gy
Radiation impacting hypothalamic-pituitary axisHyperprolactinemiaHistory/exam: galactorrhea
Prolactin level
Radiation impacting hypothalamic-pituitary axisOverweight/obesity; metabolic syndromeHeight, weight, BMI
Blood pressure
Fasting blood glucose level and lipid profile
Radiation impacting hypothalamic-pituitary axisCentral hypothyroidismFree thyroxine (Free T4) level