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Treatment Option Overview
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There are different types of treatment for patients with lip
and oral cavity cancer.
Different types of treatment are available for patients with lip
and oral cavity cancer. Some
treatments are standard (the currently used treatment), and some are being
tested in clinical trials. Before
starting treatment, patients may want to think about taking part in a clinical
trial. A treatment clinical trial is a research study meant to help improve
current treatments or obtain information on new treatments for patients with
cancer. When clinical trials show that a new treatment is better than the
standard treatment, the new
treatment may become the standard treatment.
Clinical trials are taking place in many parts of the country.
Information about ongoing clinical trials is available from the
NCI Web site. Choosing the most appropriate cancer treatment is a
decision that ideally involves the patient, family, and health care
team.
Patients with lip and oral cavity cancer should have their
treatment planned by a team of doctors who are expert in treating head and neck
cancer.
Treatment will be overseen by a medical oncologist, a doctor who specializes in
treating people with cancer. Because the lips and oral cavity are important for
breathing, eating, and talking, patients may need special help adjusting to the side effects of the cancer and its treatment. The medical oncologist may refer
the patient to other health professionals with special training in the treatment of patients
with head and neck cancer. These include the following:
Two types of standard treatment are used:
Surgery
Surgery (removing the cancer in an operation) is a common
treatment for all stages of lip and
oral cavity cancer. Surgery may include the following:
- Wide local excision: Removal of the cancer and some of the healthy tissue around it. If cancer has spread into bone, surgery may include removal of the involved bone tissue.
- Neck dissection: Removal of lymph nodes and other tissues
in the neck. This is done when cancer may have spread from the lip and oral cavity.
- Plastic surgery: An operation that restores or improves the appearance of parts of the body. Dental implants, a skin graft, or other plastic surgery may be needed to repair parts of the mouth, throat, or neck after removal of large tumors.
Even if the doctor removes all the cancer that can be seen at the time of the surgery, some patients may be given chemotherapy or radiation therapy after surgery to kill any cancer cells that are left. Treatment given after the surgery, to increase the chances of a cure, is called adjuvant therapy.
Radiation therapy
Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells. There are two types of radiation therapy. External radiation therapy uses a machine outside the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer. The way the radiation therapy is given depends on the type and stage of the cancer being treated.
For patients who smoke, radiation therapy works better when smoking is stopped before beginning treatment. It is also important for patients to have a dental exam before radiation therapy begins, so that existing problems can be treated.
New types of treatment are being tested in clinical
trials. These include the following:
Chemotherapy
Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping the cells from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the spinal column, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). The way the chemotherapy is given depends on the type and stage of the cancer being treated.
Hyperfractionated radiation therapy
Hyperfractionated radiation therapy is radiation treatment in which each day's total dose of radiation is divided into two or more smaller doses, usually given hours apart, instead of giving it all at once. This is also called superfractionated radiation therapy.
Hyperthermia therapy
Hyperthermia therapy is a
treatment in which body tissue is heated above normal temperature to damage and
kill cancer cells or to make cancer cells more sensitive to the effects of
radiation and certain anticancer drugs.
This summary section refers to specific treatments under study in
clinical trials, but it may not mention every new treatment being studied.
Information about ongoing clinical trials is available from the
NCI Web site.
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