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Lip and Oral Cavity Cancer Treatment (PDQ®)

  • Last Modified: 10/08/2014

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Treatment Options by Stage

Stage I Lip and Oral Cavity Cancer
Stage II Lip and Oral Cavity Cancer
Stage III Lip and Oral Cavity Cancer
Stage IV Lip and Oral Cavity Cancer



Stage I Lip and Oral Cavity Cancer

Treatment of stage I lip and oral cavity cancer depends on where cancer is found in the lip and oral cavity.

Lip

If cancer is in the lip, treatment may include the following:

Front of the tongue

If cancer is in the front of the tongue, treatment may include the following:

Buccal mucosa

If cancer is in the buccal mucosa (the lining of the inside of the cheeks), treatment may include the following:

Floor of the mouth

If cancer is in the floor (bottom) of the mouth, treatment may include the following:

Lower gingiva

If cancer is in the lower gingiva (gums), treatment may include the following:

Retromolar trigone

If cancer is in the retromolar trigone (the small area behind the wisdom teeth), treatment may include the following:

Upper gingiva or hard palate

If cancer is in the upper gingiva (gums) or the hard palate (the roof of the mouth), treatment is usually surgery (wide local excision) with or without radiation therapy.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I lip and oral cavity cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Stage II Lip and Oral Cavity Cancer

Treatment of stage II lip and oral cavity cancer depends on where cancer is found in the lip and oral cavity.

Lip

If cancer is in the lip, treatment may include the following:

Front of the tongue

If cancer is in the front of the tongue, treatment may include the following:

Buccal mucosa

If cancer is in the buccal mucosa (the lining of the inside of the cheeks), treatment may include the following:

Floor of the mouth

If cancer is in the floor (bottom) of the mouth, treatment may include the following:

Lower gingiva

If cancer is in the lower gingiva (gums), treatment may include the following:

Retromolar trigone

If cancer is in the retromolar trigone (the small area behind the wisdom teeth), treatment may include the following:

Upper gingiva or hard palate

If cancer is in the upper gingiva (gums) or the hard palate (the roof of the mouth), treatment may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage II lip and oral cavity cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Stage III Lip and Oral Cavity Cancer

Treatment of stage III lip and oral cavity cancer depends on where cancer is found in the lip and oral cavity.

Lip

If cancer is in the lip, treatment may include the following:

Front of the tongue

If cancer is in the front of the tongue, treatment may include the following:

Buccal mucosa

If cancer is in the buccal mucosa (the lining of the inside of the cheeks), treatment may include the following:

Floor of the mouth

If cancer is in the floor (bottom) of the mouth, treatment may include the following:

Lower gingiva

If cancer is in the lower gingiva (gums), treatment may include the following:

Retromolar trigone

If cancer is in the retromolar trigone (the small area behind the wisdom teeth), treatment may include the following:

Upper gingiva

If cancer is in the upper gingiva (gums), treatment may include the following:

Hard palate

If cancer is in the hard palate (the roof of the mouth), treatment may include the following:

Lymph nodes

For cancer that may have spread to lymph nodes, treatment may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III lip and oral cavity cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Stage IV Lip and Oral Cavity Cancer

Treatment of stage IV lip and oral cavity cancer depends on where cancer is found in the lip and oral cavity.

Lip

If cancer is in the lip, treatment may include the following:

Front of the tongue

If cancer is in the front of the tongue, treatment may include the following:

Buccal mucosa

If cancer is in the buccal mucosa (the lining of the inside of the cheeks), treatment may include the following:

Floor of the mouth

If cancer is in the floor (bottom) of the mouth, treatment may include the following:

Lower gingiva

If cancer is in the lower gingiva (gums), treatment may include the following:

Retromolar trigone

If cancer is in the retromolar trigone (the small area behind the wisdom teeth), treatment may include the following:

Upper gingiva or hard palate

If cancer is in the upper gingiva (gums) or hard palate (the roof of the mouth), treatment may include the following:

Lymph nodes

For cancer that may have spread to lymph nodes, treatment may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage IV lip and oral cavity cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.