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Melanoma Treatment (PDQ®)

  • Updated: 03/19/2014

Table 3. Distant Metastasis (M)a

M0No detectable evidence of distant metastases.
M1aMetastases to skin, subcutaneous, or distant lymph nodes.
M1bMetastases to lung.
M1cMetastases to all other visceral sites or distant metastases to any site combined with an elevated serum LDH.
Note: Serum LDH is incorporated into the M category as shown below:
M Classification Site Serum LDH
M1aDistant skin, subcutaneous, or nodal mets.Normal.
M1bLung metastases.Normal.
M1cAll other visceral metastases.Normal.
Any distant metastasis.Elevated.

LDH = lactate dehydrogenase.
aReprinted with permission from AJCC: Melanoma of the skin. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 325-44.