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Melanoma Treatment (PDQ®)

  • Updated: 09/19/2014

Table 4. TNM Definitions for Stage II Melanoma

Stage TNM Description Image 
Clinicala Pathologicalb
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Three-panel drawing of stage II melanoma. The left panel shows two stage IIA tumors. One tumor is more than 1 but not more than 2 millimeters thick, with ulceration (break in the skin); the other tumor is more than 2 but not more than 4 millimeters thick, with no ulceration. The right panel shows two stage IIB tumors. One tumor is more than 2 but not more than 4 millimeters thick, with ulceration; the other tumor is more than 4 millimeters thick, with no ulceration. The bottom panel shows a stage IIC tumor that is more than 4 millimeters thick, with ulceration. Also shown are the epidermis (outer layer of the skin), the dermis (inner layer of the skin), and the subcutaneous tissue below the dermis.
Stage II melanoma.
IIAIIAT2bMelanomas 1.01–2.0 mm in thickness with ulceration
T3aMelanomas 2.01–4.0 mm in thickness without ulceration
N0No regional metastases detected
M0No detectable evidence of distant metastases
IIBIIBT3bMelanomas 2.01–4.0 mm in thickness with ulceration
T4aMelanomas >4.0 mm in thickness without ulceration
N0No regional metastases detected
M0No detectable evidence of distant metastases
IICIICT4bMelanomas >4.0 mm in thickness with ulceration
N0No regional metastases detected
M0No detectable evidence of distant metastases
T = primary tumor; N = regional lymph nodes; M = distant metastasis.
Adapted with permission from AJCC: Melanoma of the skin. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 325-44.
The explanations for superscripts a and b are at the end of Table 7.