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Table 6. TNM Definitions for Stage III Melanoma: Pathologic Stagingb

Stage TNM Description 
IIIAT1–4aT1a = Melanomas ≤1.0 mm in thickness without ulceration; mitosis <1/mm2
T1b = Melanomas ≤1.0 mm in thickness with ulceration or mitoses ≥1/mm2
T2a = Melanomas 1.01–2.0 mm in thickness without ulceration
T2b = Melanomas 1.01–2.0 mm in thickness with ulceration
T3a = Melanomas 2.01–4.0 mm in thickness without ulceration
T3b = Melanomas 2.01–4.0 mm in thickness with ulceration
T4a = Melanomas >4.0 mm in thickness without ulceration
N1a1 regional lymph node metastasis with micrometastasisc
N2a2–3 regional lymph node metastases with micrometastasisc
M0No detectable evidence of distant metastases
IIIBT1–4bT1a = Melanomas ≤1.0 mm in thickness without ulceration; mitosis <1/mm2
T1b = Melanomas ≤1.0 mm in thickness with ulceration or mitoses ≥1/mm2
T2a = Melanomas 1.01–2.0 mm in thickness without ulceration
T2b = Melanomas 1.01–2.0 mm in thickness with ulceration
T3a = Melanomas 2.01–4.0 mm in thickness without ulceration
T3b = Melanomas 2.01–4.0 mm in thickness with ulceration
T4a = Melanomas >4.0 mm in thickness without ulceration
T4b = Melanomas >4.0 mm in thickness with ulceration
N1a1 regional lymph node metastasis with micrometastasisc
N2a2–3 regional lymph node metastases with micrometastasisc
M0No detectable evidence of distant metastases
IIIBT1–4aT1a = Melanomas ≤1.0 mm in thickness without ulceration; mitosis <1/mm2
T1b = Melanomas ≤1.0 mm in thickness with ulceration or mitoses ≥1/mm2
T2a = Melanomas 1.01–2.0 mm in thickness without ulceration
T2b = Melanomas 1.01–2.0 mm in thickness with ulceration
T3a = Melanomas 2.01–4.0 mm in thickness without ulceration
T3b = Melanomas 2.01–4.0 mm in thickness with ulceration
T4a = Melanomas >4.0 mm in thickness without ulceration
N1bN1b = 1 regional lymph node metastasis with macrometastasisd
N2bN2b = 2–3 regional lymph node metastases with macrometastasisd
N2cN2c = In transit met(s)/satellite(s) without metastatic lymph nodes
M0No detectable evidence of distant metastases
IIICT1–4bT1a = Melanomas ≤1.0 mm in thickness without ulceration; mitosis <1/mm2
T1b = Melanomas ≤1.0 mm in thickness with ulceration or mitoses ≥1/mm2
T2a = Melanomas 1.01–2.0 mm in thickness without ulceration
T2b = Melanomas 1.01–2.0 mm in thickness with ulceration
T3a = Melanomas 2.01–4.0 mm in thickness without ulceration
T3b = Melanomas 2.01–4.0 mm in thickness with ulceration
T4a = Melanomas >4.0 mm in thickness without ulceration
T4b = Melanomas >4.0 mm in thickness with ulceration
N1bN1b = 1 regional lymph node metastasis with macrometastasisd
N2bN2b = 2–3 regional lymph node metastases with macrometastasisd
N2cN2c = In transit met(s)/satellite(s) without metastatic lymph nodes
M0No detectable evidence of distant metastases
IIICAny TTX = Primary tumor cannot be assessed (e.g., curettaged or severely regressed melanoma)
T0 = No evidence of primary tumor
Tis = Melanoma in situ
T1a = Melanomas ≤1.0 mm in thickness without ulceration; mitosis <1/mm2
T1b = Melanomas ≤1.0 mm in thickness with ulceration or mitoses ≥1/mm2
T2a = Melanomas 1.01–2.0 mm in thickness without ulceration.
T2b = Melanomas 1.01–2.0 mm in thickness with ulceration
T3a = Melanomas 2.01–4.0 mm in thickness without ulceration
T3b = Melanomas 2.01–4.0 mm in thickness with ulceration
T4a = Melanomas >4.0 mm in thickness without ulceration
T4b = Melanomas >4.0 mm in thickness with ulceration
N3≥4 regional lymph node metastases; or matted nodes; or in transit met(s)/satellite(s) with metastatic lymph node(s)
M0No detectable evidence of distant metastases
T = primary tumor; N = regional lymph nodes; M = distant metastasis.
Adapted with permission from AJCC: Melanoma of the skin. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 325-44.
The explanations for superscripts b–d are at the end of Table 7.