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Table 8. Standard Treatment Options for Melanoma

Stage (TNM Staging Criteria)  Standard Treatment Optionsa 
aClinical trials are an important option for patients with all stages of melanoma because advances in understanding the aberrant molecular and biologic pathways have led to rapid drug development. Standard treatment options are available in many clinical trials. Information about ongoing clinical trials is available from the NCI Web site.
Stage 0 melanomaExcision
Stage I melanomaExcision +/− lymph node management
Stage II melanomaExcision +/− lymph node management
Resectable Stage III melanomaExcision +/− lymph node management
Unresectable Stage III, Stage IV, and Recurrent melanomaImmunotherapy
Signal transduction inhibitors
Chemotherapy
Palliative local therapy