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Table 4. International Neuroblastoma Risk Group Staging Systema

Stage Description 
aAdapted from Monclair et al.[22]
L1 Localized tumor not involving vital structures as defined by the list of image-defined risk factorsa and confined to one body compartment.
L2 Locoregional tumor with presence of one or more image-defined risk factors.a
M Distant metastatic disease (except MS).
MS Metastatic disease in children younger than 18 months with metastases confined to skin, liver, and/or bone marrow.


  1. Monclair T, Brodeur GM, Ambros PF, et al.: The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J Clin Oncol 27 (2): 298-303, 2009.  [PUBMED Abstract]