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Paranasal Sinus and Nasal Cavity Cancer Treatment (PDQ®)

Treatment Options by Stage

Stage I Paranasal Sinus and Nasal Cavity Cancer

Treatment of stage I paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I paranasal sinus and nasal cavity cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Stage II Paranasal Sinus and Nasal Cavity Cancer

Treatment of stage II paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage II paranasal sinus and nasal cavity cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Stage III Paranasal Sinus and Nasal Cavity Cancer

Treatment of stage III paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity.

If cancer is in the maxillary sinus, treatment may include the following:

If cancer is in the ethmoid sinus, treatment may include the following:

If cancer is in the sphenoid sinus, treatment is the same as for nasopharyngeal cancer, usually radiation therapy with or without chemotherapy. (See the PDQ summary on Nasopharyngeal Cancer Treatment for more information.)

If cancer is in the nasal cavity, treatment may include the following:

  • Surgery and/or radiation therapy.
  • Chemotherapy and radiation therapy.
  • A clinical trial of combination chemotherapy before surgery or radiation therapy.
  • A clinical trial of combination chemotherapy after surgery or other cancer treatment.

For inverting papilloma, treatment is usually surgery with or without radiation therapy.

For melanoma and sarcoma, treatment may include the following:

  • Surgery.
  • Radiation therapy.
  • Surgery, radiation therapy, and chemotherapy.

For midline granuloma, treatment is usually radiation therapy.

If cancer is in the nasal vestibule, treatment may include the following:

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III paranasal sinus and nasal cavity cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Stage IV Paranasal Sinus and Nasal Cavity Cancer

Treatment of stage IV paranasal sinus and nasal cavity cancer depends on where cancer is found in the paranasal sinuses and nasal cavity.

If cancer is in the maxillary sinus, treatment may include the following:

If cancer is in the ethmoid sinus, treatment may include the following:

  • Radiation therapy before or after surgery.
  • Chemotherapy and radiation therapy.
  • A clinical trial of chemotherapy before surgery or radiation therapy.
  • A clinical trial of chemotherapy after surgery or other cancer treatment.
  • A clinical trial of chemotherapy and radiation therapy.

If cancer is in the sphenoid sinus, treatment is the same as for nasopharyngeal cancer, usually radiation therapy with or without chemotherapy. (See the PDQ summary on Nasopharyngeal Cancer Treatment for more information.)

If cancer is in the nasal cavity, treatment may include the following:

  • Surgery and/or radiation therapy.
  • Chemotherapy and radiation therapy.
  • A clinical trial of chemotherapy before surgery or radiation therapy.
  • A clinical trial of chemotherapy after surgery or other cancer treatment.
  • A clinical trial of chemotherapy and radiation therapy.

For inverting papilloma, treatment is usually surgery with or without radiation therapy.

For melanoma and sarcoma, treatment may include the following:

  • Surgery.
  • Radiation therapy.
  • Chemotherapy.

For midline granuloma, treatment is usually radiation therapy.

If cancer is in the nasal vestibule, treatment may include the following:

  • External radiation therapy and/or internal radiation therapy with or without surgery.
  • A clinical trial of chemotherapy before surgery or radiation therapy.
  • A clinical trial of chemotherapy after surgery or other cancer treatment.
  • A clinical trial of chemotherapy and radiation therapy.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage IV paranasal sinus and nasal cavity cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

  • Updated: October 8, 2014