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Prostate Cancer Treatment (PDQ®)

  • Updated: 10/28/2014

Table 2. Definitions of TNM Stage II

Stage TNM Description 
IIAT1a, N0, M0, G2–4T1a = Tumor incidental histologic finding in ≤5% of tissue resected.
N0 = No regional lymph node metastasis.
M0 = No distant metastasis.a
G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).
IIAT1b, N0, M0, any GT1b = Tumor incidental histologic finding in >5% of tissue resected.
N0 = No regional lymph node metastasis.
M0 = No distant metastasis.a
GX = Grade cannot be assessed.
G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).
IIAT1c, N0, M0, any GT1c = Tumor identified by needle biopsy (e.g., because of elevated PSA).
N0 = No regional lymph node metastasis.
M0 = No distant metastasis.a
GX = Grade cannot be assessed.
G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).
IIBT1, N0, M0, any GT1 = Clinically inapparent tumor neither palpable nor visible by imaging.
N0 = No regional lymph node metastasis.
M0 = No distant metastasis.a
GX = Grade cannot be assessed.
G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).
IIBT2, N0, M0, any GT2 = Tumor confined within prostate.b
N0 = No regional lymph node metastasis.
M0 = No distant metastasis.a
GX = Grade cannot be assessed.
G1 = Well differentiated (slight anaplasia) (Gleason score of 2–4).
G2 = Moderately differentiated (moderate anaplasia) (Gleason score of 5–6).
G3–4 = Poorly differentiated or undifferentiated (marked anaplasia) (Gleason score of 7–10).

T = Primary tumor; N = Regional lymph nodes; M = Distant metastasis; G = Histopathologic grade.
Reprinted with permission from AJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
The explanations for superscripts a and b are at the end of Table 4.