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Table 4. Anatomic Stage/Prognostic Groupsa,b

Stage T N M Dukesc MACc 
0TisN0M0----
IT1N0M0AA
T2N0M0AB1
IIAT3N0M0BB2
IIBT4aN0M0BB2
IICT4bN0M0BB3
IIIAT1–T2N1/N1cM0CC1
T1N2aM0CC1
IIIBT3–T4aN1/N1cM0CC2
T2–T3N2aM0CC1/C2
T1–T2N2bM0CC1
IIICT4aN2aM0CC2
T3–T4aN2bM0CC2
T4bN1–N2M0CC3
IVAAny TAny NM1a----
IVBAny TAny NM1b----

aReprinted with permission from AJCC: Colon and rectum. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 143-164.
bcTNM is the clinical classification, and pTNM is the pathologic classification. The y prefix is used for those cancers that are classified after neoadjuvant pretreatment (e.g., ypTNM). Patients who have a complete pathologic response (ypT0, N0, cM0) may be similar to stage group 0 or I. The r prefix is to be used for those cancers that have recurred after a disease-free interval (rTNM).
cDukes B is a composite of better (T3, N0, M0) and worse (T4, N0, M0) prognostic groups, as is Dukes C (any T, N1, M0 and any T, N2, M0). MAC is the modified Astler-Coller classification.