Information Summaries from PDQ
Drugs Approved for Melanoma
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for melanoma. The list includes generic names and brand names.
Clinical Trials to Treat Melanoma
Check for melanoma treatment trials from NCI's list of cancer cllinical trials now accepting patients. The list of clinical trials can be refined by location, stage of disease, drug, and other features.
Clinical Trials to Treat Intraocular (Eye) Melanoma
Check for intraocular (eye) melanoma treatment trials from NCI's list of cancer trials now accepting patients. The list of clinical trials can be refined by location, stage of disease, drug, and other features.
Combining Two Types of Targeted Therapy Improves Survival in Some Patients with Advanced Melanoma
In two phase III trials, patients with metastatic melanoma whose tumors have specific mutations in the BRAF gene lived longer following treatment with dabrafenib (Tafinlar®), a BRAF inhibitor, plus trametinib (Mekinist®), a MEK inhibitor, than following treatment with a BRAF inhibitor alone.
Nivolumab Improves Overall Survival in Patients with Metastatic Melanoma without a BRAF Mutation
Results from an international phase III trial show that nivolumab (Opdivo®) improves overall survival compared with the chemotherapy drug dacarbazine in patients with metastatic melanoma whose tumors do not have a mutation in the BRAF gene.
New Therapies Are Changing the Outlook for Advanced Melanoma
In the last several years, after decades of little progress, a host of new treatment options have been produced for patients with the skin cancer melanoma. Since 2011, the FDA has approved seven new treatments for advanced melanoma that has spread to other parts of the body. And the progress is showing no signs of slowing.
MEK: A Single Drug Target Shows Promise in Multiple Cancers
Drugs that block the MEK protein have shown promise in several cancers. Trametinib has had encouraging results in patients with advanced melanoma, and selumetinib has been tested in patients with advanced thyroid and ovarian cancers.
Related Treatment Information
Sentinel Lymph Node Biopsy
A fact sheet that describes the sentinel lymph node biopsy (SLNB) procedure, its use in determining the extent, or stage, of cancer in the body, and the results of research on the use of SLNB in breast cancer and melanoma.
A fact sheet that describes the process of eliminating the blood supply to tumors. Lists the cancers in which this approach is being tested.
Biological Therapies for Cancer
A fact sheet that provides an overview of how the immune system functions and describes the actions of biological therapies, such as monoclonal antibodies, cytokines, therapeutic vaccines, the bacterium bacillus Calmet-Guérin, cancer-killing viruses, gene therapy, and adoptive T-cell transfer.
Targeted Cancer Therapies
A fact sheet that describes targeted cancer therapies, which are drugs that interfere with specific molecules involved in cancer cell growth and survival.
A fact sheet about metastasis, the spread of cancer to other parts of the body. Discusses the diagnosis and treatment of cancer that has spread.